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Genetic deletion or pharmacological inhibition of soluble epoxide hydrolase r...
Abstract Background Inflammatory responses significantly contribute to neuronal damage and poor functional outcomes following intracerebral hemorrhage (ICH). Soluble epoxide... -
Prolonged preoperative treatment of acromegaly with Somatostatin analogs may ...
Abstract Background This study aimed to investigate preoperative somatostatin analogs (SSAs) treatment on the surgical outcome in patients with acromegaly. Methods An analysis... -
Prevention of doxorubicin-induced Cardiotoxicity by pharmacological non-hypox...
Abstract Background Anthracycline-induced cardiotoxicity (AIC), a condition associated with multiple mechanisms of damage, including oxidative stress, has been associated with... -
Toll-Like Receptor 4 Engagement Inhibits Adenosine 5′-Monophosphate-Activated...
Abstract Despite the potent antiinflammatory effects of pharmacologically induced adenosine 5′-monophosphate kinase (AMPK) activation on Toll-like receptor 4 (TLR4)-induced... -
Serum periostin levels following small bone fractures, long bone fractures an...
Abstract Background In asthma, serum periostin may potentially be used as a biomarker in the management of patients with Type-2 eosinophilic airway inflammation. However, serum... -
Silica nanoparticles induce neurodegeneration-like changes in behavior, neuro...
Abstract Background Silica nanoparticles (SiO2-NPs) are naturally enriched and broadly utilized in the manufacturing industry. While previous studies have demonstrated toxicity... -
Oleogel-S10 Phase 3 study "EASE" for epidermolysis bullosa: study design and ...
Abstract Background Epidermolysis bullosa (EB) is a group of rare, genetic diseases that affect the integrity of epithelial tissues, most notably the skin. Patients experience... -
Cocaine-mediated induction of microglial activation involves the ER stress-TL...
Abstract Background Neuroinflammation associated with advanced human immunodeficiency virus (HIV)-1 infection is often exacerbated by chronic cocaine abuse. Cocaine exposure has... -
Healthcare cost comparison analysis of nivolumab in combination with ipilimum...
Abstract Background Monoclonal antibodies targeting the cytotoxic T-lymphocyte-associated antigen 4 (CTLA4) (e.g., ipilimumab [IPI]) and the programmed cell death-1 (PD1)... -
Neuropsychological profiles of adult bipolar disorder patients with and witho...
Abstract Background Comorbid attention-deficit/hyperactivity disorder (ADHD) is common in bipolar disorder and associated with worse outcomes. Cognitive testing might be a tool... -
Four thiol-oxidoreductases involved in the formation of disulphide bonds in t...
Abstract Background Bacterial secretory proteins often require the formation of disulphide bonds outside the cell to acquire an active conformation. Thiol-disulphide... -
Microglial depletion and repopulation in brain slice culture normalizes sensi...
Abstract Background Microglia are critical mediators of neuroimmune pathology across multiple neurologic disorders. Microglia can be persistently activated or “primed” by... -
A case report of one vasovagal syncope patient with third-degree atrioventric...
Abstract Background Vasovagal syncope (VVS) is common in children and significantly affects their quality of life. To our knowledge, this the first case report of SCN5A gene... -
Development of type 2 diabetes mellitus quality indicators in general practic...
Abstract Background The service capacity of primary care has improved in China. General practice also takes growing responsibility in the management of type 2 diabetes mellitus,... -
Association of statin use and clinical outcomes in heart failure patients: a ...
Abstract Background The role of statins in patients with heart failure (HF) of different levels of left ventricular ejection fraction (LVEF) remains unclear especially in the... -
A p53/TIAF1/WWOX triad exerts cancer suppression but may cause brain protein ...
Abstract Background Tumor suppressor WWOX physically binds p53 and TIAF1 and together induces apoptosis and tumor suppression. To understand the molecular action, here we...
