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Which potential harms and benefits of using ginger in the management of nause...
Abstract Background Nausea and vomiting of pregnancy (NVP) affect approximately 80â 90% of the pregnant women. Ginger (Zingiber officinale Roscoe) is the most widely used... -
A principal components method constrained by elementary flux modes: analysis ...
Abstract Background Non-negative linear combinations of elementary flux modes (EMs) describe all feasible reaction flux distributions for a given metabolic network under the... -
Six-month adherence to Statin use and subsequent risk of major adverse cardio...
Abstract Background The evidence of adherence to statin decreasing risk of major adverse cardiovascular events (MACEs) is still lack among patients discharged with acute... -
Pulse actinomycin D as first-line treatment of low-risk post-molar non-chorio...
Abstract Background Little data exists predicting the resistance to actinomycin D (Act-D) single-agent for gestational trophoblastic neoplasia (GTN). The objective was to... -
Developing a measure of polypharmacy appropriateness in primary care: systema...
Abstract Background Polypharmacy is an increasing challenge for primary care. Although sometimes clinically justified, polypharmacy can be inappropriate, leading to undesirable... -
Patient-reported outcomes from a randomized phase II study of the deferasirox...
Abstract Background Adherence to long-term chelation therapy in transfusion-dependent patients is critical to prevent iron overload-related complications. Once-daily deferasirox... -
Effect of extra-amniotic Foley’s catheter and vaginal misoprostol versus vagi...
Abstract Background The safest, most effective and fastest combined approaches to induction of labor is unknown. In an open-label randomized clinical trial we evaluated the... -
Development of a core outcome set for clinical trials in squamous cell carcin...
Abstract Background Squamous cell carcinoma (SCC) is a common skin cancer that poses a risk of metastasis. Clinical investigations into SCC treatment are common, but the... -
Self-medication during pregnancy and associated factors among pregnant women ...
Abstract Objective The use of self-medications during pregnancy results in serious structural as well as functional adverse effects on mothers and unborn children. But little is... -
A mutation that blocks integrin α4β7 activation prevents adaptive immune-medi...
Abstract Background β7 integrins are responsible for the efficient recruitment of lymphocytes from the blood and their retention in gut-associated lymphoid tissues. Integrin... -
Safety, tolerability and efficacy of intra-articular Progenza in knee osteoar...
Abstract Background Cell therapies are being investigated as potential disease modifying treatment options for osteoarthritis (OA). Progenza (PRG) comprises in vitro expanded... -
Role of mesenchymal stem cells, their derived factors, and extracellular vesi...
Abstract Liver failure is a severe clinical syndrome with a poor prognosis. Mesenchymal stem cell (MSC) transplantation has emerged as a new intervention in treating liver... -
Central mechanisms of real and sham electroacupuncture in the treatment of ch...
Abstract Background Chronic low back pain (CLBP) is the most common chronic pain condition and is often resistant to conventional treatments. Acupuncture is a popular... -
Survival after recurrence in patients with gastric cancer who receive S-1 adj...
Abstract Background Some patients develop recurrence after curative resection and adjuvant chemotherapy. S-1, an oral fluoropyrimidine, is one of the standard regimens in... -
Adequacy of risk of bias assessment in surgical vs non-surgical trials in Coc...
Abstract Background Bias in randomized controlled trials (RCTs) can lead to underestimation or overestimation of the true effects of interventions. Surgical RCTs may suffer from... -
TLR7/8 agonist induces a post-entry SAMHD1-independent block to HIV-1 infecti...
Abstract Background Monocytes, the primary myeloid cell-type in peripheral blood, are resistant to HIV-1 infection as a result of the lentiviral restriction factor SAMHD1.... -
VEGF-121 plasma level as biomarker for response to anti-angiogenetic therapy ...
Abstract Background Vascular endothelial growth factor (VEGF) isoforms, particularly the diffusible VEGF-121, could play a major role in the response of recurrent glioblastoma... -
Birth preparedness and complication readiness among pregnant women admitted i...
Abstract Background With an aim to prevent adverse pregnancy outcomes, ‘birth preparedness and complication readiness’ (BP/CR) promotes timely access to skilled maternal and... -
A multicenter randomized trial of personalized acupuncture, fixed acupuncture...
Abstract Background Traditional Chinese medicine (TCM) usually involves syndrome differentiation and treatment. Acupuncture, one form of TCM, requires the selection of... -
Prophylactic antibiotics for the prevention of infection following operative ...
Abstract Background Sepsis is one of the most important causes of maternal death and severe morbidity worldwide. Studies conducted both in the UK and US have documented an...
