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Bursicon-α subunit modulates dLGR2 activity in the adult <i>Drosophila melano...
Bursicon is the main regulator of post molting and post eclosion processes during arthropod development. The active Bursicon hormone is a heterodimer of Burs-α and Burs-β.... -
The randomised uterine septum transsection trial (TRUST): design and protocol
Abstract Background A septate uterus is a uterine anomaly that may affect reproductive outcome, and is associated with an increased risk for miscarriage, subfertility and... -
Evaluating interventions for informed consent for surgery (ICONS): Protocol f...
Abstract Background The concept of informed consent is fundamental to medical practice. Shortcomings in the process can lead to patient complaints, litigation, unmet... -
A new set of cluster driven composite development indicators
Abstract Composite development indicators used in policy making often subjectively aggregate a restricted set of indicators. We show, using dimensionality reduction techniques,... -
Association between factors related to the pregnancy, neonatal period, and la...
Abstract Background Studies about the majority of the factors that may potentially influence the pubertal timing and menarche were controversial. The objective was to evaluate... -
Cardiovascular disease risk factor responses to a type 2 diabetes care model ...
Abstract Background Cardiovascular disease (CVD) is a leading cause of death among adults with type 2 diabetes mellitus (T2D). We recently reported that glycemic control in... -
Sex differences in cardiovascular epigeneticsâ a systematic review
Abstract Background Differences in cardiovascular diseases are evident in men and women throughout life and are mainly attributed to the presence of sex hormones and... -
Meta-analysis of GWAS on both Chinese and European populations identifies GPR...
Abstract Background Systemic lupus erythematous (SLE) is a complex autoimmune disease with female predominance, particularly affecting those of childbearing age. We performed... -
PROX1 and β-catenin are prognostic markers in pancreatic ductal adenocarcinoma
Abstract Background The Wnt/β-catenin pathway has a key role in regulating cellular processes and its aberrant signaling can lead... -
Peripheral blood metabolome predicts mood change-related activity in mouse mo...
Abstract Bipolar disorder is a major mental illness characterized by severe swings in mood and activity levels which occur with variable amplitude and frequency. Attempts have... -
Development of a core outcome set for clinical trials in squamous cell carcin...
Abstract Background Squamous cell carcinoma (SCC) is a common skin cancer that poses a risk of metastasis. Clinical investigations into SCC treatment are common, but the... -
The regional association between bronchiectasis and lung cancer in chest CT
Abstract Background Limited studies have examined the association between lung cancer and bronchiectasis (BE). This study evaluated the regional association between BE and lung... -
Fidelity of DNA polymerases in the detection of intraindividual variation of ...
Here we investigated the consequences of PCR amplification errors in the identification of intraindividual mtDNA variation. The bumblebee Bombus morio was chosen as model for... -
Do state insurance mandates alter ICSI utilization?
Abstract Background Assisted reproductive technology (ART) insurance mandates resulted in improved access to infertility treatments like intracytoplasmic sperm injection (ICSI).... -
Abdominal obesity increases metabolic risk factors in non-obese adults: a Hun...
Abstract Background The prevalence of abdominal obesity is increasing worldwide. Adults with abdominal obesity have been reported to have increased risk of cardiometabolic... -
Epithelial and interstitial Notch1 activity contributes to the myofibroblasti...
Abstract Background Notch1 signalling is a stem-cell-related pathway that is essential for embryonic development, tissue regeneration and organogenesis. However, the role of... -
Simultaneous single-shot real-time measurement of the instantaneous frequency...
A self-reference, single-shot characterization technique is proposed and demonstrated for simultaneously measuring the instantaneous frequencies and phases of multi-wavelength... -
Exercise challenge alters Default Mode Network dynamics in Gulf War Illness
Abstract Background Gulf War Illness (GWI) affects 30% of veterans from the 1991 Gulf War and has no known cause. Everyday symptoms include pain, fatigue, migraines, and... -
Low priority of obesity education leads to lack of medical students’ prepared...
Abstract Background Physicians are currently unprepared to treat patients with obesity, which is of great concern given the obesity epidemic in the United States. This study... -
Self-reported impulsivity in women with borderline personality disorder: the ...
Abstract Background Childhood maltreatment, such as severe emotional, physical, and sexual abuse and neglect, has been linked to impulse control problems and dysfunctional...
