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Common variants in SIRT1 and human longevity in a Chinese population
Abstract Background The silent information regulator SIR2/SIRT1gene has been demonstrated as regulating lifespan in many model organisms, including yeast, worms, fruit flies and... -
In utero exposure to ultrafine particles promotes placental stress-induced pr...
Abstract Background Exposure to particulate matter (PM) is associated with an adverse intrauterine environment, which can promote adult cardiovascular disease (CVD) risk.... -
Suppression of peripheral NGF attenuates neuropathic pain induced by chronic ...
Abstract Background Anti-nerve growth factor (NGF) monoclonal antibodies (anti-NGF mAbs) have been reported to significantly attenuate pain, but the mechanism involved has not... -
Advancing the pathologic phenotype of giant axonal neuropathy: early involvem...
Abstract Giant axonal neuropathy (GAN; ORPHA: 643; OMIM# 256850) is a rare, hereditary, pediatric neurodegenerative disorder associated with intracellular accumulations of... -
A pilot study of essential tremor: cerebellar GABA+/Glx ratio is correlated w...
Abstract Objective Essential tremor is a common movement disorder with an unclear origin. Emerging evidence suggests the role of the cerebellum and the thalamus in tremor... -
Heme oxygenase-1 promoter region (GT)n polymorphism associates with increased...
Abstract Background Heme oxygenase-1 (HO-1) is a critical cytoprotective enzyme that limits oxidative stress, inflammation, and cellular injury within the central nervous system... -
Assignment of sigma factors of RNA polymerase to promoters in Corynebacterium...
Abstract Corynebacterium glutamicum is an important industrial producer of various amino acids and other metabolites. The C. glutamicum genome encodes seven sigma subunits... -
Maternal and cord blood adiponectin levels in relation to post-natal body siz...
Abstract Background Adiponectin is an adipocyte hormone involved in energy homeostasis and metabolism. However, its role in early infancy is poorly understood. Methods We... -
Do fragments and glycosylated isoforms of alpha-1-antitrypsin in CSF mirror s...
Abstract Background Post-translational modifications (PTMs) generate a tremendous protein diversity from the ~ 20,000 protein-coding genes of the human genome. In chronic pain... -
Visualization of activity-regulated BDNF expression in the living mouse brain...
Abstract Altered levels of brain-derived neurotrophic factor (BDNF) have been reported in neurologically diseased human brains. Therefore, it is important to understand how the... -
Sensitization profile in patients with respiratory allergic diseases: differe...
Abstract Background Component-resolved diagnosis (CRD) allows to identify single molecular allergen components, and constitutes a routine practice in many allergy units.... -
Controlling heterologous gene expression in yeast cell factories ...
Abstract Background Predictable control of gene expression is necessary for the rational design and optimization of cell factories. In the yeast Saccharomyces cerevisiae, the... -
A cure for the blues: opsin duplication and subfunctionalization for short-wa...
Abstract Background Arthropods have received much attention as a model for studying opsin evolution in invertebrates. Yet, relatively few studies have investigated the diversity...
