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r37980778c78--b83177d0c6de60e307794c8ade834f8e
l-Fucose, 6-deoxy-l-galactose, is a key component of many important glycoconjugates including the blood group antigens and the LewisX ligands. The biosynthesis of GDP-l-fucose... -
Discovery of 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,...
Efforts to identify a suitable follow-on compound to razaxaban (compound 4) focused on modification of the carboxamido linker to eliminate potential in vivo hydrolysis to a... -
Evolving Carbapenemases: Can Medicinal Chemists Advance One Step Ahead of the...
Carbapenems can be an effective treatment of infections with multidrug-resistant Gram-negative bacteria such as Pseudomonas aeruginosa,1 Acinetobacter spp.,2 Klebsiella... -
r37980778c78--1432abdeb57253465dd8e782cca54e4b
A fluorescent deoxyuridine analogue is sensitive to the polarity of its environment and exhibits a distinct emission profile in single- vs double-stranded oligonucleotides.... -
dedup_wf_001--4edd6b37544e4fc6acb3bb4fce0088b7
A major bottleneck for the exploitation of data from the Kepler mission for stellar astrophysics and exoplanet research has been the lack of precise radii and evolutionary... -
r37980778c78--56fcee8741a21a8729fa2db393bd30b0
Design, synthesis, and in vitro bioevaluation of a new class of potential dual PPARα and γ agonists discovered through a structure-driven design paradigm are described. The... -
r37980778c78--20d5cb9ef2131f7c2f5fd1f5ab7c3f3a
The development of n-pentenyl furanosyl donors has been tested using arabinose as a model. The readily prepared ortho ester (NPOE) is converted into disarmed (NPGAC) and thence... -
r37980778c78--80e6641dc0cdeb3b20f1f6a7ec7fe7d9
Mobile applications of hydrogen power have long demanded new solid hydride materials with large hydrogen storage capacities. We report synthesis of a new quaternary hydride... -
r37980778c78--e669c313d8a9cdc92fd1159467d7eb1e
The derivatives of ethylenediamine-N,N,N‘,N‘-tetraamides were prepared, and their crystal structures were analyzed in order to understand the variations in their molecular and... -
Pyrazolo[1,5-a]quinazoline scaffold as 5-deaza analogue of pyrazolo[5,1-c][1,...
To investigate the binding affinity of GABAA receptor subtype, new pyrazolo [1,5-a]quinazolines were designed, synthesized, and in vitro evaluated. These compounds, 5-deaza... -
Design and Synthesis of 5‘-Deoxy-5‘-Phenyladenophostin A, a Highly Potent IP<...
5‘-Deoxy-5‘-phenyladenophostin A (5), designed as a useful IP3 receptor ligand based on the previous structure−activity relationship studies, was successfully synthesized via... -
dedup_wf_001--a2becc5a08d1798af30764d21dfdcdbf
Se ofrecen los contenidos del curso "Visión integral de las bibliotecas: función, valor, servicios, recursos, usuarios y estrategias" impartido por personal académico de la... -
Design and Synthesis of Potent Cystine-Free Cyclic Hexapeptide Agonists at th...
Cyclic hexapeptides, incorporating a dipeptide unit in place of the disulfide bond found in urotensin, were prepared and screened at the human urotensin receptor. The bridging... -
In vitro and In vivo Optical Imaging Using Water-Dispersible, Noncytotoxic, L...
A facile method for synthesis of monodisperse, biocompatible, silica coated CdSe/CdS/ZnS quantum rods (QRs) and their use as probes for in vitro and in vivo optical bioimaging... -
Efficient Isomerization of Allyl Ethers and Related Compounds Using Pentacarb...
Efficient Isomerization of Allyl Ethers and Related Compounds Using Pentacarbonyliron -
Additional file 1 of Non-target screening of organic pollutants and target an...
Additional file 1: Table S1. Gas chromatography (GC) and mass spectrometry (MS) conditions. Table S2. Aliphatic hydrocarbons in air samples screened by GC/Q-TOF-MS. Table S3.... -
Competition between Intramolecular Electron-Transfer and Energy-Transfer Proc...
Photoinduced intramolecular processes in a dyad of azulene and C60 (Az−C60) were compared with those of a dyad of naphthalene and C60 (Naph−C60) on the basis of laser flash... -
r37980778c78--f4212394947eb4c34f741297838e3540
Chemically Reversible Organogels: Aliphatic Amines as “Latent” Gelators with Carbon Dioxide -
r37980778c78--45c77806280e278526960e808d2b7b2b
Electrolysis of benzylthiocyanate, benzyl chloride, p-methylbenzyl chloride, p-methoxybenzyl chloride, or toluene in acetonitrile, at platinum electrodes in a two compartments... -
Synthesis and Src Kinase Inhibitory Activity of 2-Phenyl- and 2-Thienyl-7-phe...
2-Phenyl-7-phenylaminothieno[3,2-b]pyridine-6-carbonitriles were recently reported to be inhibitors of Src kinase activity. In this study we present structure−activity...
