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The role of antifungals in the management of patients with severe asthma
Abstract In patients with asthma, the inhalation of elevated amounts of fungal spores and hyphae may precipitate the onset of asthma or worsen control to the extent of being... -
Measurement of plasma norepinephrine and 3,4-dihydroxyphenylglycol: method de...
Abstract Objective Norepinephrine (NE), a sympathetic neurotransmitter, is often measured in plasma as an index of sympathetic activity. To better understand NE dynamics, it is... -
Activin and TGFβ use diverging mitogenic signaling in advanced colon cancer
Abstract Background Understanding cell signaling pathways that contribute to metastatic colon cancer is critical to risk stratification in the era of personalized therapeutics.... -
Reduction in clinically important deterioration in chronic obstructive pulmon...
Abstract Background ‘Clinically important deterioration’ (CID) is a composite endpoint measuring worsening of the key clinical features of chronic obstructive pulmonary disease... -
Association of plasma soluble CD14 level with asthma severity in adults: a ca...
Abstract Background Soluble CD14 (sCD14) shedding from CD14 could regulate T lymphocyte activation and function, which has implicated in the pathogenesis of bronchial asthma.... -
Lagovirus europeus GI.2 (rabbit hemorrhagic disease virus 2) infection in cap...
Abstract Background Rabbit hemorrhagic disease virus (RHDV, Lagovirus europeus GI.1) induces a contagious and highly lethal hemorrhagic disease in rabbits. In 2010 a new... -
Training emergency physicians in sex- and gender-based medicine: assessing at...
Abstract Background Sex and gender influence disease presentation, treatment, healthcare access, and long-term outcomes. It is uncertain to what extent sex- and gender-based... -
Replication competence of virions induced from CD4+ lymphocytes latently infe...
Abstract Latently infected CD4 lymphocytes preclude cure of HIV infection, even with the most effective antiretroviral therapy. The replication competent latent HIV reservoir... -
TNFAIP3 is required for FGFR1 activation-promoted proliferation and tumorigen...
Abstract Background Although ductal carcinoma in situ (DCIS) is a non-invasive breast cancer, many DCIS lesions may progress to invasive cancer and the genes and pathways... -
Astragaloside IV inhibits lung cancer progression and metastasis by modulatin...
Abstract Background Accumulating evidence suggests that M2-polarized tumor-associated macrophages (TAMs) play an important role in cancer progression and metastasis, making M2... -
Beyond the two compartments Petri-dish: optimising growth promotion and induc...
Abstract Background Bacterial volatiles promote plant growth and elicit immunity responses in plants grown in two-compartment Petri dishes. Due to the limitations of bacterial... -
Efficacy and safety of ipratropium bromide/albuterol compared with albuterol ...
Abstract Background Many patients with asthma require frequent rescue medication for acute symptoms despite appropriate controller therapies. Thus, determining the most... -
Ethnopharmacologic survey of medicinal plants used to treat human diseases by...
Abstract Background One of the services that plants provide for human beings is their wider medicinal application. Although it is not fully assessed, the practice and wider use... -
Education of pediatric subspecialty fellows in transport medicine: a national...
Abstract Background The transport of critically ill patients to children’s hospitals is essential to current practice. The AAP Section on Transport Medicine has raised concerns... -
Price variation among different brands of anticancer medicines available in h...
Abstract Objective To assess the variation in price among different brands of anticancer medicines available in hospital pharmacies at Nepalese cancer hospitals. Methods The... -
An analysis of discrepancies between United Kingdom cancer research funding a...
Abstract Background Ideally, the allocation of research funding for each specific type of cancer should be proportional to its societal burden. This burden can be estimated with... -
MaveDB: an open-source platform to distribute and interpret data from multipl...
Abstract Multiplex assays of variant effect (MAVEs), such as deep mutational scans and massively parallel reporter assays, test thousands of sequence variants in a single... -
A principal components method constrained by elementary flux modes: analysis ...
Abstract Background Non-negative linear combinations of elementary flux modes (EMs) describe all feasible reaction flux distributions for a given metabolic network under the... -
Characterizing and prognosticating chronic lymphocytic leukemia in the elderl...
Abstract Background Median age at diagnosis of patients with chronic lymphocytic leukemia (CLL) is > 70 years. However, the majority of clinical trials do not reflect the... -
The cotton GhWIN2 gene activates the cuticle biosynthesis pathway and influen...
Abstract Background Metabolic pathways are interconnected and yet relatively independent. Genes involved in metabolic modules are required for the modules to run. Study of the...
