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The role of antifungals in the management of patients with severe asthma
Abstract In patients with asthma, the inhalation of elevated amounts of fungal spores and hyphae may precipitate the onset of asthma or worsen control to the extent of being... -
Measurement of plasma norepinephrine and 3,4-dihydroxyphenylglycol: method de...
Abstract Objective Norepinephrine (NE), a sympathetic neurotransmitter, is often measured in plasma as an index of sympathetic activity. To better understand NE dynamics, it is... -
Activin and TGFβ use diverging mitogenic signaling in advanced colon cancer
Abstract Background Understanding cell signaling pathways that contribute to metastatic colon cancer is critical to risk stratification in the era of personalized therapeutics.... -
Reduction in clinically important deterioration in chronic obstructive pulmon...
Abstract Background ‘Clinically important deterioration’ (CID) is a composite endpoint measuring worsening of the key clinical features of chronic obstructive pulmonary disease... -
Association of plasma soluble CD14 level with asthma severity in adults: a ca...
Abstract Background Soluble CD14 (sCD14) shedding from CD14 could regulate T lymphocyte activation and function, which has implicated in the pathogenesis of bronchial asthma.... -
Replication competence of virions induced from CD4+ lymphocytes latently infe...
Abstract Latently infected CD4 lymphocytes preclude cure of HIV infection, even with the most effective antiretroviral therapy. The replication competent latent HIV reservoir... -
Astragaloside IV inhibits lung cancer progression and metastasis by modulatin...
Abstract Background Accumulating evidence suggests that M2-polarized tumor-associated macrophages (TAMs) play an important role in cancer progression and metastasis, making M2... -
Efficacy and safety of ipratropium bromide/albuterol compared with albuterol ...
Abstract Background Many patients with asthma require frequent rescue medication for acute symptoms despite appropriate controller therapies. Thus, determining the most... -
MaveDB: an open-source platform to distribute and interpret data from multipl...
Abstract Multiplex assays of variant effect (MAVEs), such as deep mutational scans and massively parallel reporter assays, test thousands of sequence variants in a single... -
Characterizing and prognosticating chronic lymphocytic leukemia in the elderl...
Abstract Background Median age at diagnosis of patients with chronic lymphocytic leukemia (CLL) is > 70 years. However, the majority of clinical trials do not reflect the... -
The cotton GhWIN2 gene activates the cuticle biosynthesis pathway and influen...
Abstract Background Metabolic pathways are interconnected and yet relatively independent. Genes involved in metabolic modules are required for the modules to run. Study of the... -
Regulation of platelet-activating factor-mediated interleukin-6 promoter acti...
Abstract Background An underlying state of inflammation is thought to be an important cause of cardiovascular disease. Among cells involved in the early steps of... -
TLR7/8 agonist induces a post-entry SAMHD1-independent block to HIV-1 infecti...
Abstract Background Monocytes, the primary myeloid cell-type in peripheral blood, are resistant to HIV-1 infection as a result of the lentiviral restriction factor SAMHD1.... -
Herbal medicine use during breastfeeding: a cross-sectional study among mothe...
Abstract Background The use of medications, including herbal medicines during breastfeeding is always a concern among women. Currently, there is no published evidence on whether... -
Treatment of relapsed/refractory chronic lymphocytic leukemia/small lymphocyt...
Abstract Background Bruton tyrosine kinase (BTK) inhibitors have demonstrated a high degree of efficacy in the treatment of B cell malignancies characterized by constitutive B... -
Citrus limetta peels: a promising substrate for the production of multienzyme...
Abstract Citrus limetta peels (CLP), a waste material generated by juice industries, has scarcely been reported for the production of yeast enzymes. The study was conducted to... -
2-methyl butyramide, a previously identified urine biomarker for Ascaris lumb...
Abstract ᅟ Previous reports suggest that the 2-methyl butyramide and 2-methyl valeramide metabolites of Ascaris lumbricoides in urine of infected individuals could be considered... -
CHI3L1 polymorphisms, cord blood YKL-40 levels and later asthma development
Abstract Background Single nucleotide polymorphisms (SNPs) in chitinase 3-like 1 (CHI3L1), the gene encoding YKL-40, and increased serum YKL-40 levels are associated with severe... -
Age-specific incidence of allergic and non-allergic asthma
Abstract Background Onset of allergic asthma has a strong association with childhood but only a few studies have analyzed incidence of asthma from childhood to late adulthood in... -
Evaluating medicine prices, availability and affordability in Bangladesh usin...
Abstract Background Previous studies have shown limited availability of medicines in health facilities in Bangladesh. While medicines are dispensed for free in public...
