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TBCRC 002: a phase II, randomized, open-label trial of preoperative letrozole...
Abstract Background In preclinical studies, the expression of vascular endothelial growth factor (VEGF) in hormone receptor-positive breast cancer is associated with... -
The human fetal adrenal produces cortisol but no detectable aldosterone throu...
Abstract Background Human fetal adrenal glands are highly active and, with the placenta, regulate circulating progesterone, estrogen and corticosteroids in the fetus. At birth... -
11β-HSD1 plays a critical role in trabecular bone loss associated with system...
Abstract Background Despite their efficacy in the treatment of chronic inflammation, the prolonged application of therapeutic glucocorticoids (GCs) is limited by significant... -
Clinical and subclinical endometritis induced alterations in bovine endometri...
Abstract Background Clinical and subclinical endometritis are known to affect the fertility of dairy cows by inducing uterine inflammation. We hypothesized that clinical or... -
Comparative transcriptome profiling of two Brassica napus cultivars under chr...
Abstract Background Chromium (Cr) being multifarious industrial used element, is considered a potential environmental threat. Cr found to be a prospective water and soil... -
Temporal multiplexing with adaptive optics for simultaneous vision
We present and test a methodology for generating simultaneous vision with a deformable mirror that changed shape at 50 Hz between two vergences: 0 D (far vision) and −2.5 D... -
Characterization of B-BOX gene family and their expression profiles under hor...
Abstract Background B-box (BBX) proteins play important roles in plant growth regulation and development including photomorphogenesis, photoperiodic regulation of flowering, and... -
Adverse effects of Hif1a mutation and maternal diabetes on the offspring heart
Abstract Background Epidemiological studies show that maternal diabetes predisposes offspring to cardiovascular and metabolic disorders. However, the precise mechanisms for the... -
Grape seed-derived procyanidins alleviate gout pain via NLRP3 inflammasome su...
Abstract Background Gout is one of the common inflammatory arthritis which affects many people for inflicting unbearable pain. Macrophage-mediated inflammation plays an... -
Clinical significance and risk factors for new onset and recurring atrial fib...
Abstract Background Although mortality after cardiac surgery has significantly decreased in the last decade, patients still experience clinically relevant postoperative... -
IL-10/STAT3 is reduced in childhood obesity with hypertriglyceridemia and is ...
Abstract Background The prevalence of childhood obesity and obesity-related metabolic disorder such as dyslipidemia has sharply increased in the past few decades. Chronic... -
The protective effects of Resveratrol against radiation-induced intestinal in...
Abstract Background Intestinal injury is a potential cause of death after high-dose radiation exposure. The aim of the present study was to investigate the protective effects of... -
Epigenetic suppression of liver X receptor β in anterior cingulate cortex by ...
Abstract Background Liver X receptors (LXRs), including LXRα and LXRβ, are key regulators of transcriptional programs for both cholesterol homeostasis and inflammation in the... -
Electro-oculography in bilateral optic neuropathy
Abstract Objective Effect of bilateral, optic neuropathy on the function of retinal pigment epithelium has not been investigated extensively to date. This study aimed to... -
Development of a new promoter to avoid the silencing of genes in the producti...
Abstract Background The production of recombinant proteins in mammalian cell lines is one of the most important areas in biopharmaceutical industry. Viral transcriptional... -
Hyperglycemia affects global 5-methylcytosine and 5-hydroxymethylcytosine in ...
Abstract Background Accumulating evidence suggests that epigenetic changes play key roles in the pathogenesis of type 2 diabetes mellitus (T2DM). However, the dynamic regulation... -
Loki zupa alleviates inflammatory and fibrotic responses in cigarette smoke i...
Abstract Background Loki zupa formula is kind of a traditional medicines which used to treat airway diseases, especially those caused by abnormal phlegm, such as cough, asthma... -
Suppression of MyD88-dependent signaling alleviates neuropathic pain induced ...
Abstract Background MyD88 is the adaptor protein of MyD88-dependent signaling pathway of TLRs and IL-1 receptor and regulates innate immune response. However, it was not clear... -
A new set of cluster driven composite development indicators
Abstract Composite development indicators used in policy making often subjectively aggregate a restricted set of indicators. We show, using dimensionality reduction techniques,... -
Monocarboxylate transporter 1 promotes classical microglial activation and pr...
Abstract Background Microglia, the resident macrophages of central nervous system, have been initially categorized into two opposite phenotypes: classical activation related to...
