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Influence of genetic variants on toxicity to anti-tubercular agents: a system...
MR is supported partly by Liverpool Reviews and Implementation Group (LRiG), based on funding from the National Institute for Health Research Health Technology Assessment... -
Activin and TGFβ use diverging mitogenic signaling in advanced colon cancer
Abstract Background Understanding cell signaling pathways that contribute to metastatic colon cancer is critical to risk stratification in the era of personalized therapeutics.... -
Adherence to standard-dose or low-dose statin treatment and low-density lipop...
To determine the association between adherence, dose and low-density lipoprotein (LDL) cholesterol response in patients with type 2 diabetes initiating statin treatment. This... -
Complementary and alternative medicine use: Results from a descriptive study ...
Abstract Background The use of CAM by pregnant women is very popular in developed countries. The trend is increasing globally and lack of evidence of safety particularly when... -
Reduction in clinically important deterioration in chronic obstructive pulmon...
Abstract Background ‘Clinically important deterioration’ (CID) is a composite endpoint measuring worsening of the key clinical features of chronic obstructive pulmonary disease... -
Efficacy and safety of everolimus in combination with trastuzumab and paclita...
Abstract Background The current exploratory analysis was performed to evaluate the efficacy and safety of everolimus for treatment of human epidermal growth factor receptor... -
Role of renal function in risk assessment of target non-attainment after stan...
Abstract Background Severe bacterial infections remain a major challenge in intensive care units because of their high prevalence and mortality. Adequate antibiotic exposure has... -
YY-1224, a terpene trilactone-strengthened Ginkgo biloba, attenuates neurodeg...
Abstract Background Ginkgo biloba has been reported to possess free radical-scavenging antioxidant activity and anti-inflammatory properties. In our pilot study, YY-1224, a... -
The COMET Handbook: Version 1.0
Abstract The selection of appropriate outcomes is crucial when designing clinical trials in order to compare the effects of different interventions directly. For the findings to... -
Topical application of Jaungo in atopic dermatitis patients: study protocol f...
Abstract Background Atopic dermatitis (AD) is a common pruritic inflammatory skin disease with increasing prevalence. It can manifest with many different clinical phenotypes;... -
Creation of a core outcome set for clinical trials of people with shoulder pa...
Abstract Background The selection of appropriate outcomes or domains is crucial when designing clinical trials, to appreciate the effects of different interventions, pool... -
Reverse Shoulder Arthroplasty for the treatment of Proximal humeral fractures...
Abstract Background Proximal humeral fractures are common in older patients. The majority are minimally displaced and are associated with good outcomes after nonoperative... -
Cost effectiveness of pre-referral antimalarial treatment in severe malaria a...
Abstract Background In 2013, 78% of malaria deaths occurred in children aged 5Â years and below, in sub-Saharan Africa. Treatment of severe malaria requires a health facility... -
General practitioner use of a C-reactive protein point-of-care test to help t...
Abstract Background Most patients presenting with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) in primary care are prescribed an antibiotic, which may... -
Uva-ursi extract and ibuprofen as alternative treatments of adult female urin...
Abstract Background Women with acute uncomplicated urine infection are usually treated with antibiotics. One trial has demonstrated that delayed antibiotic treatment offered... -
Ethnopharmacologic survey of medicinal plants used to treat human diseases by...
Abstract Background One of the services that plants provide for human beings is their wider medicinal application. Although it is not fully assessed, the practice and wider use... -
A comparison of generic drug prices in seven European countries: a methodolog...
Abstract Background Policymakers and researchers frequently compare the prices of medicines between countries. Such comparisons often serve as barometers of how pricing and... -
Education of pediatric subspecialty fellows in transport medicine: a national...
Abstract Background The transport of critically ill patients to children’s hospitals is essential to current practice. The AAP Section on Transport Medicine has raised concerns... -
Number needed to treat (NNT) in clinical literature: an appraisal
Abstract Background The number needed to treat (NNT) is an absolute effect measure that has been used to assess beneficial and harmful effects of medical interventions. Several... -
Current practice of antibiotic prophylaxis for surgical fixation of closed lo...
Abstract Background The risk of postoperative surgical site infection after long bone fracture fixation can be decreased with appropriate antibiotic use. However, there is no...
