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Engineering the enolase magnesium II binding site: implications for its evolu...
The glycolytic enzyme enolase catalyzes the reversible elimination of water from 2-phosphoglycerate (2-PGA) to form phosphoenolpyruvate (PEP). Two magnesium ions in the active... -
Structural Determinants for the Membrane Interaction of Novel Bioactive Undec...
Gaegurin 5 is a 24-residue, membrane-active antimicrobial peptide isolated from the skin of an Asian frog, Rana rugosa. We recently reported the antimicrobial activities of two... -
Oxidation of Histidine Residues in Copper−Zinc Superoxide Dismutase by Bicarb...
Cu, ZnSOD, a ubiquitous antioxidant enzyme present in the cytosol, nucleus, peroxisomes and mitochondrial intermembrane space of eukaryotic cells, protects against superoxide... -
r37980778c78--91f557755f5fb6dc2b24d2870117af2b
Bacterial glycolipids containing either α-glucuronic acid or α-galacturonic acid residues have an important role in the innate-type immune response to Gram-negative bacteria.... -
Low-Temperature Activation Conditions for PAMAM Dendrimer Templated Pt Nanopa...
Surface immobilized polyamidoamine (PAMAM) dendrimer templated Pt nanoparticles were employed as precursors to heterogeneous catalysts. CO oxidation catalysis and in situ... -
r37980778c78--8c21c6e4fa367374d5db44205e9592ae
A cytotoxic aqueous extract from the marine hydroid Gymnangium regae provided a novel linear pentapeptide, designated gymnangiamide (1). The planar structure of 1 was elucidated... -
r37980778c78--d347c3c71a7d810f6472a28a2dea472b
We showed previously that Phe303 in transmembrane segment (TM) VI of the α1B-adrenergic receptor, a highly conserved residue in G-protein-coupled receptors (GPCRs), is... -
α-Glycosphingolipids via Chelation-Induced Anomerization of <i>O</i>- and <i>...
Bacterial glycolipids containing either α-glucuronic acid or α-galacturonic acid residues have an important role in the innate-type immune response to Gram-negative bacteria.... -
r37980778c78--fb2561775dbca477365511954b00ab77
This paper provides the first direct experimental evidence for the secondary structural features of the putative second extracellular loop (ECL II) of the κ opioid receptor... -
A New Class of Selective Myocardial Calcium Channel Modulators. 2. Role of th...
In the framework of the continuing interest of this research group in the use of 8-aryl-8-hydroxy-8H-[1,4]thiazino[3,4-c][1,2,4]oxadiazol-3-ones (1) as calcium entry blockers, a... -
Morphiceptin Analogues Containing a Dipeptide Mimetic Structure: An Investig...
We describe the design, the conformational behavior, and the biological activity at the μ-opioid receptor of new morphiceptin analogues. In these analogues a recently described... -
r37980778c78--f367742c7b4457af80db9d73e9ebc2cc
Human β-defensins form a group of cysteine-rich antimicrobial peptides which have been found in epithelial tissue and, more recently, in the male genital tract. They play a role... -
Dynamic Structure of Disulfide-Removed Linear Analogs of Tachyplesin-I in the...
Tachyplesin-I (TP-I) is a 17-residue β-hairpin antimicrobial peptide containing two disulfide bonds. Linear analogs of TP-I where the four Cys residues were replaced by aromatic... -
r37980778c78--cf744c7ff3b33f8105c0260d5364230d
A structure−activity study was performed to examine the role of position 14 of human α-calcitonin gene-related peptide (h-α-CGRP) in activating the CGRP receptor. Interestingly,... -
Citrinadin A, a Novel Pentacyclic Alkaloid from Marine-Derived FungusPenicill...
A novel pentacyclic alkaloid, citrinadin A (1), was isolated from the cultured broth of the fungus Penicillium citrinum, which was separated from a marine red alga, and the... -
Determinants of affinity and activity of the anti-sigma factor AsiA.
Following infection of Escherichia coli by bacteriophage T4, phage encoded proteins bind tightly to the host RNA polymerase to direct and redirect transcription (1). One of... -
Effects of Modifications of Residues in Position 3 of Dynorphin A(1−11)-NH<su...
Tyrosine and phenylalanine4 in dynorphin A (Dyn A) have been reported to be important residues for opioid agonist activity and for potency at κ receptors. The glycine residues... -
Effects of the Substitution of Phe<sup>4</sup> in the Opioid Peptide [d-Ala<s...
Phenylalanine at position 4 of the peptide dynorphin A (Dyn A) is an important residue for opioid receptor affinity and activity, but there is very little information available...
