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Core−Shell-Type Resins for Solid-Phase Peptide Synthesis: Comparison with Ge...
Novel core−shell-type resins with a rigid core and amino-functionalized flexible shell were prepared with 2,4,6-trichloro-1,3,5-triazine (CNC) and Jeffamine ED-600 starting from... -
Synthesis, Structure−Activity Relationships, and in Vivo Evaluations of Subst...
Selective cyclooxygenase-2 (COX-2) inhibitors have been shown to be potent antiinflammatory agents with fewer side effects than currently marketed nonsteroidal antiinflammatory... -
Trace Amine-Associated Receptor Agonists: Synthesis and Evaluation of Thyron...
We have previously shown that several thyronamines, decarboxylated and deiodinated metabolites of the thyroid hormone, potently activate an orphan G protein-coupled receptor in... -
r37980778c78--da86552218363aa1b960b637f59906b3
We have previously shown that several thyronamines, decarboxylated and deiodinated metabolites of the thyroid hormone, potently activate an orphan G protein-coupled receptor in... -
Novel, Highly Potent Aldose Reductase Inhibitors: (<i>R</i>)-(−)-2-(4-Bromo-...
A series of novel tetrahydropyrrolo[1,2-a]pyrazine derivatives were synthesized and evaluated as aldose reductase inhibitors (ARIs) on the basis of their abilities to inhibit... -
Environmental Effects on Charge Densities of Biologically Active Molecules: D...
In the present paper, we investigate whether crystal and enzyme environments influence the electron density (ED) of active compounds in a similar manner. This supposition is... -
Synthesis and Biological Evaluation of a Series of Liver-Selective Phosphonic...
Phosphonic acid (PA) thyroid hormone receptor (TR) agonists were synthesized to exploit the poor distribution of PA-based drugs to extrahepatic tissues and thereby to improve...
