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Synthesis and Structure−Activity Relationship of Fluoro Analogues of 8-{2-[4-...
We have discovered high-affinity antagonists (exemplified by 11 and 12) that are the most selective for α1d-adrenergic receptors (α1d-AR) reported to date. In cloned receptor... -
Biohacking in Africa: A Tool for Justice, Empowerment, and Development
SOHA project evidences on: obstacles to the adoption of Open Science in Haiti and Africa Panel on Inclusion and Diversity MIT-MediaLab 22 – 24 september 2017 -
Renormalization-Group Equations Of Neutrino Masses And Flavor Mixing Paramete...
We apply the general idea of renormalization-group equations (RGEs) to understand how neutrino masses and flavor mixing parameters evolve when neutrinos propagate in a medium.... -
r37980778c78--98ad233a19199dd6829c44ca4f4531f4
A functional cell-based screen identified 3-(4-chlorophenyl)-3-(2-(dimethylamino)ethyl)isochroman-1-one hydrochloride (AC-7954, 1) as a nonpeptidic agonist of the urotensin-II... -
Screening of π-Basic Naphthalene and Anthracene Amplifiers for π-Acidic Synth...
Synthetic ion channels and pores attract current attention as multicomponent sensors in complex matrixes. This application requires the availability of reactive signal... -
r37980778c78--ed142d82d7e1cd5f9c6c775a5ea4072a
The aim of the study was to test the hypothesis that the biophysical interactions of the trans-activating transcriptor (TAT) peptide-conjugated nanoparticles (NPs) with a model... -
A Simple Analogue of Tumor-Promoting Aplysiatoxin Is an Antineoplastic Agent ...
Protein kinase C (PKC) is widely recognized as a therapeutic target in intractable diseases such as cancer, Alzheimer’s disease (AD), and acquired immune deficiency syndrome... -
Open Access – Ein Vorschlag zur Klassifikation und Operationalisierung
Der Begriff Open Access bezeichnet nicht nur eine bestimmte Art des wissenschaftlichen Publizierens – nämlich den leserseitig kostenlosen, freien Zugang zu Forschungsergebnissen... -
DATS 6401 – Individual Project1
Visualization-Project-1 This file including raw data, processed data, visuliaztion work with html file and some images used in html. The dataset was downloaded from the... -
r37980778c78--efbd1d634dd0fd677f1f374deb2acd59
Crude extracts of Witheringia solanacea leaves showed inhibition of NF-κB activation at 100 μg/mL induced by phorbol 12-myristate-13-acetate (PMA) in HeLa cells stably... -
Highly Diastereoselective Katsuki−Jacobsen Oxidation−Epoxidation of α-Silylox...
Katsuki−Jacobsen oxidation−epoxidation of acyclic α-silyloxy sulfinyl dienes, followed by acid-promoted cyclization, leads to 2,5-trans-sulfonyl dihydrofurans with good... -
Direct Construction of 1,3-Diaxial Diol Derivatives by C−H Hydroxylation
Direct hydroxylation of tertiary C−H bonds for construction of 1,3-diaxial diol derivatives was achieved by devising a new detachable dioxirane precursor containing a... -
New 5-Hydroxytryptamine<sub>1A</sub> Receptor Ligands Containing a Norbornene...
New arylpiperazine derivatives were prepared to identify highly selective and potent ligands for the 5-hydroxytryptamine 1A (5-HT1A) receptor as potential pharmacological tools... -
Design and Pharmacology of <i>N</i>-[(3<i>R</i>)-1,2,3,4-Tetrahydroisoquinoli...
Synthetic and natural peptides that act as nonselective melanocortin receptor agonists have been found to be anorexigenic and to stimulate erectile activity. We report the... -
Room-Temperature Desulfurization of Dibenzothiophene Mediated by [(<i>i</i>-P...
Room-Temperature Desulfurization of Dibenzothiophene Mediated by [(i-Pr2PCH2)2NiH]2 -
Inhibition of Heat Shock Induction of Heat Shock Protein 70 and Enhancement o...
Inhibitors of heat-induced heat shock protein 70 (HSP70) expression have the potential to enhance the therapeutic effectiveness of heat-induced radiosensitization of tumors.... -
r37980778c78--176e6b4e064d1574dceeb64b785b85cf
Chlorinated polycyclic aromatic hydrocarbons (ClPAHs) with 3–5 rings are ubiquitous environmental contaminants. However, toxicities of ClPAHs remain unclear. In this study, aryl... -
dedup_wf_001--d0d28e119bda642fc8bb533da9af9b61
There are very few examples detailing how plant pathogen proteins have adapted to their host environments at the resolution of single amino acids, obscuring the molecular... -
Size Distribution of Trace Organic Species Emitted from Light-Duty Gasoline V...
Size distributions for particulate hopanes+steranes and nonvolatile polycyclic aromatic hydrocarbons (PAHs) emitted from five classes of light-duty gasoline-powered vehicles... -
r37980778c78--3843ca6a5872981c082574241752069d
Obtaining highly specific and active ribonuclease activities is an important goal with numerous medical and biochemical applications. As a step toward more active and specific...
