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Total Syntheses of the Marine Pyrrole Alkaloids Polycitone A and B
Polycitone B (2) was obtained in four steps from pyrrole dicarboxylic acid 3, including Friedel−Crafts reaction of the corresponding acid chloride with anisole. The conversion... -
dedup_wf_001--23f8592d367982d23a0bd019e8ca8496
Disease progression in Tuberculosis (TB) is dependent on host’s immune system. Phyllanthus niruri, a traditional herb, has long been used to boost immune system in Indonesian... -
Tunable bifunctional silyl ether cross-linkers for the design of acid-sensiti...
Responsive polymeric biomaterials can be triggered to degrade using localized environments found in vivo. A limited number of biomaterials provide precise control over the rate... -
One-Pot and Sequential Organic Chemistry on an Enzyme Surface to Tether a Flu...
A new and simple method to tether a functional molecule at the proximity of the active site of an enzyme has been successfully developed without any activity loss. The one-pot... -
Total Synthesis of Spinosyn A. 2. Degradation Studies Involving the Pure Fact...
A total synthesis of natural levorotatory spinosyn A (1) has been achieved. The first objective, to confirm the absolute configurational assignment of tricyclic ketone 2... -
A Multifunctional 3D Ferroelectric and NLO-Active Porous Metal−Organic Framework
The tetracarboxylate organic linker and Zn(II) ions assemble into chiral building blocks for a porous metal−organic framework with ferroelectric and second-order nonlinear... -
Controlling Photochemical Geometric Isomerization of a Stilbene and Dimerizat...
Utility of a water-soluble deep cavity cavitand, octa acid, as a reaction medium is illustrated by carrying out photochemical reactions of a stilbene and a styrene included... -
The First Direct Oxidative Conversion of a Selenol to a Stable Selenenic Acid...
: [structure: see text]. A stable selenenic acid was synthesized by direct oxidation of a selenol bearing a novel bowl-type substituent with H2O2, and its structure was... -
Different C-Glycosidation Products of Glucal with Alkynyl or Propargyl Silane...
Propargylic and acetylenic silyl groups on propyne control the C-glycosidation products depending on the trimethylsilyl and triisopropylsilyl groups used. Some mechanistic... -
Squaric Acids: A New Motif for Designing Inhibitors of Protein Tyrosine Phos...
Protein tyrosine phosphatases (PTPases) are important targets in medicinal chemistry. These enzymes play a role in a number of human diseases, including type II diabetes and... -
2-Aroylbenzoyl Serine Proteases: Photoreversible Inhibition or Photoaffinity...
Phenyl esters of 2-benzoylbenzoates were determined to be inhibitors of the serine protease enzymes chymotrypsin and thrombin. Thus, p-guanidinophenyl 2-benzoylbenzoate (1b)... -
Total Synthesis of the Mycolactones
The first total synthesis of the mycolactones is reported. This work unambiguously confirms our earlier relative and absolute stereochemical assignment of the mycolactones. -
Construction of Epidithiodioxopiperazines by Directed Oxidation of Hydroxypro...
Functionalization of the angular methine carbon of hydroxyproline-derived dioxopiperazines by a radical-promoted C−H bond oxidation, which is directed by a proximal... -
Enantioselective Direct Aldol-Type Reaction of Azlactone via Protonation of V...
Highly enantio- and diastereoselective direct aldol-type reaction of azlactones with oxocarbenium ions generated by protonation of vinyl ethers using a chiral phosphoric acid... -
Zigzag Boron−Carbon Nanotubes with Quasi-planar Tetracoordinate Carbons
Four kinds of novel zigzag boron−carbon nanotubes with quasi-planar tetracoordinate carbons (2m, 0, i) (m = 3−6; i = 1−4) have been constructed, and their structures,... -
Pyridinium 1,1′-Binaphthyl-2,2′-disulfonates as Highly Effective Chiral Brøns...
We have established, for the first time, a practical synthesis of chiral 1,1′-binaphthyl-2,2′-disulfonic acid (BINSA 1) from inexpensive BINOL. An efficient enantioselective... -
Novel and Efficient Synthetic Path to Proaporphine Alkaloids: Total Synthesi...
A novel synthetic path to proaporphine alkaloids was established by employing aromatic oxidation with a hypervalent iodine reagent, where an unprecedented carbon−carbon bond... -
Triggering DNAzymes with Light: A Photoactive C8 Thioether-Linked Adenosine
Herein we report evidence for a light-inducible DNAzyme. In so doing, we also disclose the synthesis and photochemical properties of a novel nucleoside:...
