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r37980778c78--dae56b782102fa5dc48e62fb1f3bd827
Socio-demographic characteristics of the studied groups. -
Biochemical characterization of recombinant influenza A polymerase heterotrim...
Influenza polymerase is a heterotrimer protein with both endonuclease and RNA-dependent RNA polymerase (RdRp) activity. It plays a critical role in viral RNA replication and... -
Production of bioavailable flavonoid glucosides in fruit juices and green tea...
7 pages, 7 figures, 1 table. -
Rationale, Design, and Synthesis of Novel Phenyl Imidazoles as Opioid Recepto...
A small series of novel, imidazoles 4 have been prepared that exhibit very good binding affinities for the δ and μ opioid receptors (ORs), as well as demonstrate potent agonist... -
16-Aza-<i>ent</i>-beyerane and 16-Aza-<i>ent</i>-trachylobane: Potent Mechan...
The secondary ent-beyeran-16-yl carbocation (7) is a key branch point intermediate in mechanistic schemes to rationalize the cyclic structures of many tetra- and pentacyclic... -
r37980778c78--b07d9f6143d2a12a1460d36e078cdc35
N-(Carboxyalkyl)maleimides are rapid as well as time-dependent inhibitors of prostaglandin endoperoxide synthase (PGHS). The corresponding N-alkylmaleimides were only... -
r37980778c78--f83c45bbf80a91963e9a52e5ae3d922c
Poly(N-acryl amino acids) bearing side groups with a lipophilic character or having charged functional groups (i.e. −NH2, −COOH, −SH, −OH, and phenols) were synthesized from the... -
Non-Peptide Glycoprotein IIb/IIIa Antagonists. 11. Design and <i>in Vivo</i> ...
The structure−activity relationship of a series of orally active glycoprotein IIb/IIIa antagonists containing a nitrogen heterocycle grafted onto a... -
Discovery of Novel Benzopyranyl Tetracycles that Act as Inhibitors of Osteocl...
A novel benzopyran-fused molecular framework 7ai was discovered as a specific inhibitor of RANKL-induced osteoclastogenesis using a cell-based TRAP activity assay from drug-like... -
r37980778c78--c18083430c57147d4e0d635908fd56d7
A novel series of selective ligands for the human glucocorticoid receptor (hGR) are described. Preliminary structure−activity relationships were focused on substitution at C-1... -
Antitumor Activity of Bis-indole Derivatives
This paper reports the synthesis of compounds formed by two indole systems separated by a heterocycle (pyridine or piperazine). As a primary screening, the new compounds were... -
Novel Dual-Targeting Benzimidazole Urea Inhibitors of DNA Gyrase and Topoisom...
The discovery of new antibacterial agents with novel mechanisms of action is necessary to overcome the problem of bacterial resistance that affects all currently used classes of... -
Inhibition of influenza virus and crude replication complex.
Inhibition of influenza virus and crude replication complex. -
S1 Supporting Information -
Spreadsheet named "Gain & Phase" contains means and standard errors from the statistical analyses involving visual transitions. Spreadsheet named "Phase Variability" contains... -
Mode of Action of the Natural Insecticide, Decaleside Involves Sodium Pump In...
Decalesides are a new class of natural insecticides which are toxic to insects by contact via the tarsal gustatory chemosensilla. The symptoms of their toxicity to insects and... -
Cyclophilin A potentiates TRIM5α inhibition of HIV-1 nuclear import without p...
The host immunophilin cyclophilin A (CypA) binds to the capsid protein (CA) of HIV-1 and regulates its infectivity. Depending on the target cell type, CypA can either promote or... -
Phenolic compounds identified from the HPLC-DAD-MS/MS of the ethanolic extrac...
Phenolic compounds identified from the HPLC-DAD-MS/MS of the ethanolic extract of Hancornia speciosa leaves. -
Behavioral Results
Relative proportions of hits (correctly recognized pictures) are given. [Note: Delayed recognition results were not available from two participants (one His/His, one Tyr... -
Evaluation of time dependent inhibition withTbGSK3β inhibitors.
Tideglusib, AZ960, CT99021, LY278544, sorafenib, and TWS119 were evaluated for time-dependent activity. The procedures are described in Fig 4. Data are the mean of duplicate...
