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Regioselective Carboindation of Simple Alkenes with Indium Tribromide and Ket...
The regioselective carboindation of simple alkenes with indium tribromide and ketene silyl acetals was accomplished. Various alkenes such as ethylene, 1-alkenes, and cyclic... -
Effect of a 17α-(3-Hydroxypropyl)-17β-acetyl Substituent Pattern on the Gluco...
Replacing the 17α-acetoxy substituent in an antiprogestational 17β-acetyl-11β-arylestra-4,9-dien-3-one by 3-hydroxypropyl significantly diminished glucocorticoid receptor... -
Unusual Transannular Cyclization Products of Sarcophytoxide, a 14-Membered Ma...
Treatment of sarcophytoxide with trimethylsilyl trifluoromethanesulfonate afforded an aromatic ketone as an unusual cyclization product. The modified Mosher's method and X-ray... -
Reactions of α,α‘-Dihydroxy Ketones with Phosgene. Structural Requirements fo...
α,α‘-Dihydroxy ketones having two OH groups that can come into close proximity react with phosgene in the presence of DMAP to produce 1,3-dioxane-2,5-diones. When covalent... -
A New Method for the Synthesis of Branched Polysilane Anions
Lithiation by MeLi of three families of branched polysilanes (Me3Si)3Si−X {(1) X = SiMe2H, t-BuMe2Si, SiMe2SiMe3, t-BuSiMe2SiMe2; (2) X = SiMe(SiMe3)2, Si(SiMe3)3,... -
Antimalarial Activity of a New Family of Analogues of Manzamine A
Manzamine A represents an important lead structure for the development of novel antimalarial chemotherapies. The synthesis and biological evaluation of a group of simplified... -
Stereoselective Rhodium-Catalyzed Imination of Sulfides.
International audience; The preparation of optically active sulfilimines via the catalytic diastereoselective imination of sulfides using a chiral nitrene is described.... -
Enantioselective Epoxidation of Terminal Olefins by Chiral Dioxirane
This paper describes an enantioselective epoxidation of terminal olefins using chiral ketone 3 as catalyst and Oxone as oxidant. Up to 85% ee has been obtained. -
Tandem Intramolecular Nicholas and Pauson−Khand Reactions for the Synthesis o...
Simple acyclic enynes can be easily converted into tricyclic ethers upon treatment with Co2(CO)8 followed by Nicholas and Pauson−Khand reactions. Tricyclic [5,8,5]- and... -
An Unusual Oxidative Cyclization: Studies towards the Biomimetic Synthesis o...
An unusual oxidative cyclization of a N-hydroxy pyridone 9 with Z-2-cyclodecenone 11 has been achieved, thus demonstrating a possible biomimetic route to pyridomacrolidin 2. -
Stereospecific Deoxygenation of Phosphine Oxides with Retention of Configurat...
A new protocol for deoxygenation of various phosphine oxides with retention of configuration is described. The advantage of the new method includes milder conditions and... -
Practical Total Synthesis of Ciguatoxin CTX3C by Improved Protective Group St...
Ciguatoxin CTX3C is a representative congener of ciguatoxins, which are known to be the principal causative agents of ciguatera seafood poisoning. The structure of CTX3C spans... -
Diphenylprolinol Methyl Ether: A Highly Enantioselective Catalyst for Michael...
Diphenylprolinol methyl ether catalyzes intermolecular Michael addition of simple aldehydes to relatively nonactivated enones with the highest enantioselectivities reported to... -
Bifunctional Organocatalyst for Activation of Carbon Dioxide and Epoxide To P...
Bifunctional organocatalysts bearing an ammonium betaine framework have been developed as a new catalytic motif for the activation of carbon dioxide and epoxides to produce... -
Strain-Induced Regioselectivities in Reactions of Benzyne Possessing a Fused ...
A fused four-membered ring has a powerful directing ability in effecting the regioselective reactions of benzyne with ketene silyl acetal, nucleophile, and α-alkoxyfuran. -
A New Family of Macrocycles Produced by Sequential Claisen−Schmidt Condensations
Members of a new family of macrocycles have been synthesized in one step, from simple building blocks, by sequential Claisen−Schmidt condensations. -
Core−Shell-Type Resins for Solid-Phase Peptide Synthesis: Comparison with Ge...
Novel core−shell-type resins with a rigid core and amino-functionalized flexible shell were prepared with 2,4,6-trichloro-1,3,5-triazine (CNC) and Jeffamine ED-600 starting from... -
Photoinduced Electron-Transfer Bicyclopropenyl-benzene Rearrangements of 2,2‘...
The 9,10-dicyanoanthracene-sensitized photoreaction of 1-methyl- and 1,1‘-dimethyl-2,2‘,3,3‘-tetraphenylbicyclopropenyl gives the corresponding benzene and Dewar benzene... -
An Efficient C−H Oxidation Protocol for α-Hydroxylation of Cyclic Steroidal E...
Various C-16 hydroxy steroids have been prepared with the aid of CrO3/Bu4NIO4. Out of the two possible reaction courses, transition state B is favored because of less steric... -
Chirally Modified Zeolites as Reaction Media: Photochemistry of an Achiral T...
Zeolites modified with chiral inductors serve as media for performing chiral induction during photochemical reactions of organic molecules. The photochemical behavior of achiral...
