-
Pancreatic cancer-initiating cell exosome message transfer into noncancer-ini...
Abstract Background Cancer-initiating cell (CIC) exosomes (CIC-TEX) are suggested reprogramming Non-CIC. Mode of message transfer and engagement of CIC-markers being disputed,... -
Topical application of nebulized human IgG, IgA and IgAM in the lungs of rats...
Abstract Background Recurrent and persistent infections are known to affect airways of patients with Primary Immunodeficiency despite appropriate replacement immunoglobulin... -
Pharmacovigilance of suspected or confirmed therapeutic ineffectiveness of ar...
Abstract Background Therapeutic ineffectiveness of artemisinin-based combination therapy (ACT) increases the risk of malaria-related morbidity and mortality, and raises... -
Sarcandra glabra (Caoshanhu) protects mesenchymal stem cells from oxidative s...
Abstract Background Sarcandra glabra (Caoshanhu) is a traditional Chinese herbal medicine used for treating various oxidative-stressed diseases. The present work evaluated its... -
[18F]tetrafluoroborate as a PET tracer for the sodium/iodide symporter: the i...
Abstract Background [18F]BF4 −, the first 18F-labelled PET imaging agent for the sodium/iodide symporter (NIS), was produced by isotopic exchange yielding a product with limited... -
Neutrophil extracellular traps induce aggregation of washed human platelets i...
Abstract Background The release of neutrophil extracellular traps (NETs), a mesh of DNA, histones and neutrophil proteases from neutrophils, was first demonstrated as a host... -
Antioxidant activities and oxidative stress inhibitory effects of ethanol ext...
Abstract Background Cornus officinalis, is a deciduous tree native to the eastern Asia, distributes mainly in (e.g. Korea, as well as China, and Japan). It is used as folk... -
The cotton GhWIN2 gene activates the cuticle biosynthesis pathway and influen...
Abstract Background Metabolic pathways are interconnected and yet relatively independent. Genes involved in metabolic modules are required for the modules to run. Study of the... -
Development of quality indicators for non-small cell lung cancer care: a firs...
Abstract Background Large gap exists between clinical practice and recommended care and large room exists for the improvement of care quality for non-small cell lung cancer... -
Tyrosinase inhibitory activity of flavonoids from Artocarpus heterophyllous
Abstract Background Tyrosinase is an oxidoreductase that is very important in medicine and cosmetics because the excessive production of melanin causes hyperpigmentation. The... -
Acute exposure to wood smoke from incomplete combustion - indications of cyto...
Abstract Background Smoke from combustion of biomass fuels is a major risk factor for respiratory disease, but the underlying mechanisms are poorly understood. The aim of this... -
Treatments of residual pine strands: characterization and wood-cement-compati...
This paper aims to evaluate treatments on pine strands as well as wood-cement compatibility. The strands were prepared and then were submitted to four treatments (untreated;... -
Design, synthesis, and biological evaluation of novel N4-substituted sulfonam...
Abstract Background Sulfonamide derivatives are of great attention due to their wide spectrum of biological activities. Sulfonamides conjugated with acetamide fragments exhibit... -
BAX-BAK1-independent LC3B lipidation by BH3 mimetics is unrelated to BH3 mime...
Inhibition of prosurvival BCL2 family members can induce autophagy, but the mechanism is controversial. We have provided genetic evidence that BCL2 family members block... -
A mitochondrial division inhibitor, Mdivi-1, inhibits mitochondrial fragmenta...
Abstract Background Kainic acid (KA)-induced excitotoxicity promotes cytoplasmic calcium accumulation, oxidative stress, and apoptotic signaling, leading to hippocampal neuronal... -
Single nucleotide polymorphisms in apoptosis pathway are associated with resp...
Abstract Background The mechanism of action of imatinib is known to involve the Fas-mediated apoptosis pathway. Consequently inter-individual variations in this apoptosis... -
AKT1 restricts the invasive capacity of head and neck carcinoma cells harbori...
Abstract Background In mammals, the AKT/PKB protein kinase family comprises three members (AKT1–3). PI3-Kinase (PI3K), a key oncogene involved in a wide variety of cancers,... -
Anti-malarial activity of traditional Kampo medicine Coptis rhizome extract a...
Abstract Background Herbal medicine has been a rich source of new drugs exemplified by quinine and artemisinin. In this study, a variety of Japanese traditional herbal medicine... -
Long-term safety and tolerability of bapineuzumab in patients with Alzheimer’...
Abstract Background Immunotherapy with monoclonal antibodies that target amyloid beta has been under investigation as a treatment for patients with Alzheimer’s disease (AD). The... -
Melatonin receptor agonist protects against acute lung injury induced by vent...
Abstract Background It is well known that ventilation with high volume or pressure may damage healthy lungs or worsen injured lungs. Melatonin has been reported to be effective...
