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Plasma sTNFR1 and IL8 for prognostic enrichment in sepsis trials: a prospecti...
Abstract Background Enrichment strategies improve therapeutic targeting and trial efficiency, but enrichment factors for sepsis trials are lacking. We determined whether... -
CDC42 controls the activation of primordial follicles by regulating PI3K sign...
Abstract Background In mammalian females, progressive activation of dormant primordial follicles in adulthood is crucial for the maintenance of the reproductive lifespan.... -
Serum chitinase activity prognosticates metastasis of colorectal cancer
Abstract Background This study aimed to evaluate the value of chitinase activity in prognosticating the occurrence of metastasis in and prognosis of patients with colorectal... -
Efficacy and safety of Ding-Kun-Dan for female infertility patients with pred...
Abstract Background Women undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) who have a predicted poor ovarian response (POR) present a challenge... -
Tumor-associated neutrophils induce EMT by IL-17a to promote migration and in...
Abstract Purpose Epithelial to mesenchymal transition (EMT) can contribute to gastric cancer (GC) progression and recurrence following therapy. Tumor-associated neutrophils... -
Tumor-suppressor role of miR-139-5p in endometrial cancer
Abstract Background Endometrial cancer (EC) is the fourth most common malignancy of the female genital tract worldwide. MicroRNAs are important gene regulators with critical... -
Polygenic risk for coronary heart disease acts through atherosclerosis in typ...
Abstract Background Type 2 diabetes increases the risk of coronary heart disease (CHD), yet the mechanisms involved remain poorly described. Polygenic risk scores (PRS) provide... -
Association between factors related to the pregnancy, neonatal period, and la...
Abstract Background Studies about the majority of the factors that may potentially influence the pubertal timing and menarche were controversial. The objective was to evaluate... -
MTMR2 promotes invasion and metastasis of gastric cancer via inactivating IFN...
Abstract Background The aberrant expression of myotubularin-related protein 2 (MTMR2) has been found in some cancers, but little is known about the roles and clinical relevance.... -
The Reproductive Agency Scale (RAS-17): development and validation in a cross...
Abstract Background Sustainable Development Goal (SDG) 5 prioritizes women’s empowerment and gender equality, alone and as drivers of other SDGs. Efforts to validate universal... -
The role of recombinant LH in women with hypo-response to controlled ovarian ...
Abstract Objective To study the role of recombinant human LH supplementation in women with hypo-response to ovarian stimulation. Methods We performed a systematic review and... -
Patient Blood Management improves outcome in oncologic surgery
Abstract Background Patient Blood Management (PBM) is a systematic quality improving clinical model to reduce anemia and avoid transfusions in all kinds of clinical settings.... -
Comparison of the source and prognostic utility of cfDNA in trauma and sepsis
Abstract Background Circulating cell-free DNA (cfDNA) may contribute to the pathophysiology of post-injury inflammation and coagulation in trauma. However, the source and... -
Waist circumference is associated with major adverse cardiovascular events in...
Abstract Background Although studies have shown that waist circumference (WC) is positively associated with an increased risk of cardiovascular diseases among the normal... -
IVF outcomes of women with discrepancies between age and serum anti-Müllerian...
Abstract Background To determine the effects of age and the serum anti-Müllerian hormone (AMH) level on in vitro fertilization (IVF) outcomes, especially among young women with... -
Predominance and association risk of Blastocystis hominis subtype I in colore...
Abstract Background Blastocystis, a genetically diverse intestinal parasite with controversial pathogenic potential, has increasingly been incriminated for diarrheal illness in... -
CHI3L1 polymorphisms, cord blood YKL-40 levels and later asthma development
Abstract Background Single nucleotide polymorphisms (SNPs) in chitinase 3-like 1 (CHI3L1), the gene encoding YKL-40, and increased serum YKL-40 levels are associated with severe... -
Predictive performance of the estimating equations of renal function in Sri L...
Abstract Objectives This study validates two popular predictive equations of renal function firstly, Modifications of Diet in Renal Disease and secondly, Chronic Kidney Disease... -
Identifying older adults at risk of harm following elective surgery: a system...
Abstract Background Elective surgeries can be associated with significant harm to older adults. The present study aimed to identify the prognostic factors associated with the... -
Do human embryos have the ability of self-correction?
Abstract Human embryogenesis frequently coinciding with cell division mistakes contributing to pervasive embryonic aneuploidy/mosaicism. While embryo self-correction was...
