-
Factors associated with prescribing costs: analysis of a nationwide administr...
Abstract Objective All health care systems in the world struggle with rising costs for drugs. We sought to explore factors impacting on prescribing costs in a nationwide... -
Investigation of sex-specific effects of apolipoprotein E on severity of EAE ...
Abstract Background Despite pleiotropic immunomodulatory effects of apolipoprotein E (apoE) in vitro, its effects on the clinical course of experimental autoimmune... -
Prevalence and characteristics of older adults with a persistent death wish w...
Abstract Background Some older persons develop a persistent death wish without being severely ill, often referred to as “completed life” or “tiredness of life”. In the... -
Use of diagnostic tests and the appropriateness of the treatment decision in ...
Abstract Background Inappropriate prescription of antibiotics is the leading driver of antimicrobial resistance (AMR). The majority of antibiotics are prescribed in primary... -
Design and methods of the ‘monitoring outcomes of psychiatric pharmacotherapy...
Abstract Background At many outpatient departments for psychiatry worldwide, standardized monitoring of the safety of prescribed psychotropic drugs is not routinely performed in... -
Pathological complete response due to a prolonged time interval between preop...
Abstract Background Preoperative chemoradiotherapy is the recommended standard of care for patients with local advanced rectal cancer. However, it remains unclear, whether a... -
Appendectomy, cholecystectomy and diagnostic laparoscopy conducted before pre...
Abstract Background Non-obstetric surgery conducted during pregnancy may increase the risk of adverse birth outcomes like small for gestational age, preterm birth, and... -
Comparative analyses of the in vivo induction and transmission of α-synuclein...
Abstract α-synuclein (αS) is the major component of several types of brain pathological inclusions that define neurodegenerative diseases termed synucleinopathies. Central... -
Nanomedicine-driven neuropathic pain relief in a rat model is associated with...
Abstract We explored the immune neuropathology underlying multi-day relief from neuropathic pain in a rat model initiated at the sciatic nerve, by using a nanoemulsion-based... -
Open-label versus double-blind placebo treatment in irritable bowel syndrome:...
Abstract Background Placebo medications, by definition, are composed of inactive ingredients that have no physiological effect on symptoms. Nonetheless, administration of... -
Vasoresponsiveness in patients with heart failure (VASOR): protocol for a pro...
Abstract Background Vasoplegia is a severe complication which may occur after cardiac surgery, particularly in patients with heart failure. It is a result of activation of... -
Degree of dyspnoea at admission and discharge in patients with heart failure ...
Abstract Background Dyspnoea is a disabling symptom in patients admitted with heart failure (HF) and respiratory diseases (RD). The main aim of this study is to evaluate its... -
Real world experience of patients with amyotrophic lateral sclerosis (ALS) in...
Background: Treatment of spasticity poses a major challenge in amyotrophic lateral sclerosis (ALS) patient management. Delta-9-tetrahydrocannabinol (THC):cannabidiol (CBD)... -
Combination of Ranibizumab with macular laser for macular edema secondary to ...
Abstract Background It is not clear whether macular laser combined with anti-vascular endothelial growth factor (VEGF) can reduce the number of anti-VEGF injections in the... -
Efficacy of an aluminium triformate mouthrinse during the maintenance phase i...
Abstract Background The aim of this prospective placebo-controlled pilot study was to evaluate short-term effects of a mouthrinse containing aluminium triformate (ATF) on... -
Scopolamine augmentation of a newly initiated escitalopram treatment for majo...
Abstract Background Major depressive disorder (MDD) is a prevalent and disabling disorder that can lead to heavy individual, familial, and societal burdens. Although... -
Suppression of LPS-induced tau hyperphosphorylation by serum amyloid A
Abstract Background Accumulation of hyperphosphorylated tau is a major neuropathological feature of tauopathies including Alzheimer’s disease (AD). Serum amyloid A (SAA), an... -
Transient receptor potential ankyrin 1 (TRPA1) is functionally expressed in p...
Abstract Background Transient receptor potential ankyrin 1 (TRPA1) is a membrane-associated cation channel, widely expressed in neuronal cells and involved in nociception and... -
Embolizing pulmonary aspergillosis, mycobacterial & aspergillous splenic ...
Abstract Background Aspergillosis is a serious infection particularly affecting the immunodeficient host. Its co-infection with tuberculosis and cytomegalovirus has not been... -
A systematic review of surgical margins utilized for removal of cutaneous mas...
Abstract Background Traditionally, wide lateral surgical margins of 3 cm and one fascial plane deep have been recommended for resection of canine cutaneous mast cell tumor...
