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Prevalence and characteristics of older adults with a persistent death wish w...
Abstract Background Some older persons develop a persistent death wish without being severely ill, often referred to as “completed life” or “tiredness of life”. In the... -
Comparative analyses of the in vivo induction and transmission of α-synuclein...
Abstract α-synuclein (αS) is the major component of several types of brain pathological inclusions that define neurodegenerative diseases termed synucleinopathies. Central... -
Combination of Ranibizumab with macular laser for macular edema secondary to ...
Abstract Background It is not clear whether macular laser combined with anti-vascular endothelial growth factor (VEGF) can reduce the number of anti-VEGF injections in the... -
Suppression of LPS-induced tau hyperphosphorylation by serum amyloid A
Abstract Background Accumulation of hyperphosphorylated tau is a major neuropathological feature of tauopathies including Alzheimer’s disease (AD). Serum amyloid A (SAA), an... -
Transient receptor potential ankyrin 1 (TRPA1) is functionally expressed in p...
Abstract Background Transient receptor potential ankyrin 1 (TRPA1) is a membrane-associated cation channel, widely expressed in neuronal cells and involved in nociception and... -
Memory retrieval in addiction: a role for miR-105-mediated regulation of D1 r...
Abstract Background Drug addiction is a chronic brain disorder characterized by the compulsive use of drugs. The study of chronic morphine-induced adaptation in the brain and... -
Do Cochrane summaries help student midwives understand the findings of Cochra...
Abstract Background Abstracts and plain language summaries (PLS) are often the first, and sometimes the only, point of contact between readers and systematic reviews. It is... -
Efficacy of acupuncture in the prevention and treatment of chemotherapy-induc...
Abstract Background Chemotherapy-induced nausea and vomiting (CINV) is a common and distressing side effect. We conducted this clinical trial to compare the effectiveness of... -
Quality of life in subjects with upper- and lower-limb spasticity treated wit...
Abstract Background We evaluated quality of life among subjects with upper- and lower-limb spasticity who received escalating doses of incobotulinumtoxinA (total body doses up... -
A scalable cognitive behavioural program to promote healthy sleep during preg...
Abstract Background Poor sleep, including symptoms of insomnia are common during pregnancy and postpartum periods. Poor sleep during the perinatal period is linked to impaired... -
Tocilizumab in treatment-naïve patients with Takayasu arteritis: TOCITAKA Fre...
Abstract Objectives To assess long-term efficacy of tocilizumab in treatment-naive patients with Takayasu arteritis (TAK). Methods Prospective open-labeled trial in naïve... -
Epigenetic and non-epigenetic mode of SIRT1 action during oocyte meiosis prog...
Abstract Background SIRT1 histone deacetylase acts on many epigenetic and non-epigenetic targets. It is thought that SIRT1 is involved in oocyte maturation; therefore, the... -
Yy1 regulates Senp1 contributing to AMPA receptor GluR1 expression following ...
Abstract Background Neuronal activity-induced changes in gene expression patterns are important mediators of neuronal plasticity. Many neuronal genes can be activated or... -
Baseline characteristics, analysis plan and report on feasibility for the Pre...
Abstract Background A common complication after stroke is development of cognitive impairment and dementia. However, effective strategies for reducing the risk of developing... -
Ketamine-induced apoptosis in the mouse cerebral cortex follows similar chara...
Abstract The effects of general anesthetics on inducing neuronal apoptosis during early brain development are well-documented. However, since physiological apoptosis also occurs... -
A novel monoclonal antibody against the von Willebrand Factor A2 domain reduc...
Abstract We developed a novel murine monoclonal antibody (mAb) against the C-terminal Îą-helix of the human von Willebrand factor A2, designated SZ-179. We showed that SZ-179... -
Neural hyperactivity in the amygdala induced by chronic treatment of rats wit...
Abstract Background Patients with medication-overuse headache suffer not only from chronic headache, but often from psychiatric comorbidities, such as anxiety and depression.... -
Clinical outcomes and radiologic assessment of a modified suture button arthr...
Abstract Background As several neurologic and hardware complications have been reported with screw fixation. Suture buttons are used to serve as an alternative to screw fixation... -
Glibenclamide in aneurysmatic subarachnoid hemorrhage (GASH): study protocol ...
Abstract Background Recent findings on the benefits of glibenclamide as a neuroprotective drug have started a new era for prospective studies on sulfonylureas. The effect of... -
Youth Depression Alleviation with Anti-inflammatory Agents (YoDA-A): a random...
Abstract Background Inflammation contributes to the pathophysiology of major depressive disorder (MDD), and anti-inflammatory strategies might therefore have therapeutic...
