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Using predicate and provenance information from a knowledge graph for drug ef...
Abstract Background Biomedical knowledge graphs have become important tools to computationally analyse the comprehensive body of biomedical knowledge. They represent knowledge... -
Gene expression prediction using low-rank matrix completion
Abstract Background An exponential growth of high-throughput biological information and data has occurred in the past decade, supported by technologies, such as microarrays and... -
Math for the Benefit of Society: A New MATLAB-Based Gen-Ed Course
Responding to a call for national reform of mathematical education, as well as a college-wide revision of general education (GE) requirements, we describe a new entry-level, GE... -
Status of metered dose inhaler technique among patients with asthma and its e...
Abstract Objective In Asthma management, poor handling of inhalation devices and wrong inhalation technique are associated with decreased medication delivery and poor disease... -
Involvement of DPP9 in gene fusions in serous ovarian carcinoma
Abstract Background A fusion gene is a hybrid gene consisting of parts from two previously independent genes. Chromosomal rearrangements leading to gene breakage are frequent in... -
Association between sexual violence and unintended pregnancy among adolescent...
Abstract Background Unintended pregnancy has dire consequences on the health and socioeconomic wellbeing of adolescent girls and young women (AGYW) (aged 15–24 years). While... -
Pediatric asthma comprises different phenotypic clusters with unique nasal mi...
Abstract Background Pediatric asthma is the most common chronic childhood disease in the USA, currently affecting ~ 7 million children. This heterogeneous syndrome is thought to... -
Detailed analysis of sputum and systemic inflammation in asthma phenotypes: a...
Abstract Background The technique of induced sputum has allowed to subdivide asthma patients into inflammatory phenotypes according to their level of granulocyte airway... -
Development of a Microsoft Excel tool for applying a factor retention criteri...
Abstract Background Many quality-of-life studies have been conducted in healthcare settings, but few have used Microsoft Excel to incorporate Cronbach’s α with dimension... -
Development and validation of a score to identify in the Emergency Department...
Abstract Background Risk stratification methods developed on the basis of predicting illness severity are often used to prioritise patients on the basis of urgency. Illness... -
Lifetime secondhand smoke exposure and childhood and adolescent asthma: findi...
Abstract Background Secondhand smoke (SHS) exposure is a modifiable risk factor associated with childhood asthma. Associations with adolescent asthma and the relevance of the... -
Polygenic risk for coronary heart disease acts through atherosclerosis in typ...
Abstract Background Type 2 diabetes increases the risk of coronary heart disease (CHD), yet the mechanisms involved remain poorly described. Polygenic risk scores (PRS) provide... -
MaveDB: an open-source platform to distribute and interpret data from multipl...
Abstract Multiplex assays of variant effect (MAVEs), such as deep mutational scans and massively parallel reporter assays, test thousands of sequence variants in a single... -
Application of machine learning methodology to assess the performance of DIAB...
Abstract Background The study aimed to assess the performance of a multidisciplinary-team diabetes care program called DIABETIMSS on glycemic control of type 2 diabetes (T2D)... -
Ovarian cycling and reproductive state shape the vaginal microbiota in wild b...
Abstract Background The vaginal microbiome is an important site of bacterial-mammalian symbiosis. This symbiosis is currently best characterized for humans, where lactobacilli... -
Genetic determinants of growth hormone and GH-related phenotypes
Abstract Background Higher fasting Growth Hormone (GH) has been associated with increased cardiovascular morbidity and mortality. Our objective was to find genetic determinants... -
Accurate determination of node and arc multiplicities in de bruijn graphs usi...
Abstract Background De Bruijn graphs are key data structures for the analysis of next-generation sequencing data. They efficiently represent the overlap between reads and hence,... -
Surmounting obstacles by arm maneuver for unmanned power shovel
Abstract Large debris created after natural disasters restrict access to inner parts of affected regions, and slows down disaster relief operations. Power shovels are often used... -
Comprehensive discovery of subsample gene expression components by informatio...
Abstract Background De novo inference of clinically relevant gene function relationships from tumor RNA-seq remains a challenging task. Current methods typically either... -
Can human experts predict solubility better than computers?
Abstract In this study, we design and carry out a survey, asking human experts to predict the aqueous solubility of druglike organic compounds. We investigate whether these...
