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Identifying targets for antibiotic stewardship interventions through analysis...
Abstract Background In order to change antibiotic prescribing behaviour, we need to understand the prescribing process. The aim of this study was to identify targets for... -
Cortical vein thrombosis in adult patients of cerebral venous sinus thrombosi...
Abstract Background Cortical vein thrombosis (CVT) receives little attention in adult patients with cerebral venous sinus thrombosis (CVST). This study aimed to investigate the... -
Transcriptionally induced enhancers in the macrophage immune response to Myco...
Abstract Background Tuberculosis is a life-threatening infectious disease caused by Mycobacterium tuberculosis (M.tb). M.tb subverts host immune responses to build a favourable... -
Combination of Ranibizumab with macular laser for macular edema secondary to ...
Abstract Background It is not clear whether macular laser combined with anti-vascular endothelial growth factor (VEGF) can reduce the number of anti-VEGF injections in the... -
The role of human Metapneumovirus genetic diversity and nasopharyngeal viral ...
Abstract Background Human metapneumovirus (HMPV) is established as one of the causative agents of respiratory tract infections. To date, there are limited reports that describe... -
Pervasive read-through transcription of T-DNAs is frequent in tobacco BY-2 ce...
Abstract Background Plant transformation via Agrobacterium tumefaciens is characterized by integration of commonly low number of T-DNAs at random positions in the genome. When... -
The role of antifungals in the management of patients with severe asthma
Abstract In patients with asthma, the inhalation of elevated amounts of fungal spores and hyphae may precipitate the onset of asthma or worsen control to the extent of being... -
Oxidative stress enhances the expression of IL-33 in human airway epithelial ...
Abstract Background Interleukin-33 (IL-33) is a cytokine belonging to the IL-1 family, and its possible involvement in the pathophysiology of COPD and viral-induced... -
Divergent transcriptomic responses underlying the ranaviruses-amphibian inter...
Abstract Background Ranaviruses (family Iridoviridae, nucleocytoplasmic large DNA viruses) have been reported as promiscuous pathogens of cold-blooded vertebrates. Rana grylio... -
Ubiquitous giants: a plethora of giant viruses found in Brazil and Antarctica
Abstract Background Since the discovery of giant viruses infecting amoebae in 2003, many dogmas of virology have been revised and the search for these viruses has been... -
Respiratory virus-associated infections in HIV-infected adults admitted to th...
Abstract Introduction Acute respiratory failure is the main reason for admission to the intensive care unit (ICU) in HIV-infected adults. There is little data about the... -
A transgenerational role of the germline nuclear RNAi pathway in repressing h...
Abstract Background Environmental stress-induced transgenerational epigenetic effects have been observed in various model organisms and human. The capacity and mechanism of such... -
A genome-wide siRNA screen identifies a druggable host pathway essential for ...
Abstract Background The 2014–2016 Ebola virus (EBOV) outbreak in West Africa highlighted the need for improved therapeutic options against this virus. Approaches targeting host... -
A double-blind, randomised, placebo-controlled study of roxithromycin and dox...
Abstract Background Azithromycin prophylaxis has been shown to reduce COPD exacerbations but there is poor evidence for other antibiotics. We compared exacerbation rates in COPD... -
Efficacy and safety of ascending doses of praziquantel against Schistosoma ha...
Abstract Background Despite decades of experience with praziquantel treatment in school-aged children (SAC) and adults, we still face considerable knowledge gaps relevant to the... -
Lagovirus europeus GI.2 (rabbit hemorrhagic disease virus 2) infection in cap...
Abstract Background Rabbit hemorrhagic disease virus (RHDV, Lagovirus europeus GI.1) induces a contagious and highly lethal hemorrhagic disease in rabbits. In 2010 a new... -
A rare case of Colistin-resistant Salmonella Enteritidis meningitis in an HIV...
Abstract Background Non-typhoidal salmonellae (NTS) have been associated with invasive disease, notably meningitis, in immunocompromised individuals. Infections of this nature... -
Replication competence of virions induced from CD4+ lymphocytes latently infe...
Abstract Latently infected CD4 lymphocytes preclude cure of HIV infection, even with the most effective antiretroviral therapy. The replication competent latent HIV reservoir... -
Suspicion of respiratory tract infection with multidrug-resistant Enterobacte...
Abstract Background Multidrug-resistant (MDR) infections are a serious concern for children admitted to the Paediatric Intensive Care Unit (PICU). Tracheal colonization with MDR... -
Distinct immune responses of juvenile and adult oysters (Crassostrea gigas) t...
Abstract Since 2008, massive mortality events of Pacific oysters (Crassostrea gigas) have been reported worldwide and these disease events are often associated with Ostreid...
