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Impact of merging commercial breeding lines on the genetic diversity of Landr...
Abstract Background The pig breeding industry has undergone a large number of mergers in the past decades. Various commercial lines were merged or discontinued, which is... -
Tumor necrosis factor-alpha promotes survival in methotrexate-exposed macroph...
Abstract Introduction Methotrexate (MTX) induces macrophage apoptosis in vitro, but there is not much evidence for increased synovial macrophage apoptosis in MTX-treated... -
Profile of regional fat and fat-free soft tissue accumulation in male athletes
Abstract Background It is unclear whether or not the breakpoint (BP), at which the proportion of each of fat mass (FM) and fat-free soft tissue mass (FFSTM) to body mass (BM)... -
AKT1 restricts the invasive capacity of head and neck carcinoma cells harbori...
Abstract Background In mammals, the AKT/PKB protein kinase family comprises three members (AKT1–3). PI3-Kinase (PI3K), a key oncogene involved in a wide variety of cancers,... -
Assessment of completeness and legibility of handwritten prescriptions in six...
Abstract Background Incompleteness and illegibility of prescriptions are prescription errors that account for a high proportion of medication errors that could potentially... -
Risks of miscarriage and inadvertent exposure to artemisinin derivatives in t...
Abstract Background The artemisinin anti-malarials are widely deployed as artemisinin-based combination therapy (ACT). However, they are not recommended for uncomplicated... -
Regional heterogeneity in response of airway epithelial cells to cigarette smoke
Abstract Background Cigarette smoke (CS) exposure causes an abnormal inflammatory response, which can result in chronic obstructive pulmonary disease (COPD). Previous studies... -
Differences between evidence-based recommendations and actual clinical practi...
Abstract Background International guidelines recommend that tocolytic therapy be restricted to a single 48-h application. However, multiple cycles of tocolytic therapy and... -
Methodology of assessment and reporting of safety in anti-malarial treatment ...
Abstract Background Considering the uncertainty of safety of anti-malarial drugs in pregnancy, efficacy studies are one of the few sources of clinical safety data. Complete... -
Assessment of adverse events via a telephone consultation service for cancer ...
Abstract Background An increasing number of cancer patients are receiving ambulatory chemotherapy to improve their quality of life and reduce medical expenses. During outpatient... -
Anti-malarial activity of traditional Kampo medicine Coptis rhizome extract a...
Abstract Background Herbal medicine has been a rich source of new drugs exemplified by quinine and artemisinin. In this study, a variety of Japanese traditional herbal medicine... -
Long-term safety and tolerability of bapineuzumab in patients with Alzheimer’...
Abstract Background Immunotherapy with monoclonal antibodies that target amyloid beta has been under investigation as a treatment for patients with Alzheimer’s disease (AD). The... -
The influence of pregnancy on the pharmacokinetic properties of artemisinin c...
Abstract Background Pregnancy has been reported to alter the pharmacokinetic properties of anti-malarial drugs, including the different components of artemisinin-based... -
Treatment outcomes of drug-resistant tuberculosis in the Netherlands, 2005–2015
Abstract Background Since in low incidence TB countries population migration and complex treatment of drug-resistant tuberculosis (DR-TB) patients are major issues, we aimed to... -
A randomised clinical trial of a metaphylactic treatment with tildipirosin fo...
Abstract Background Bovine respiratory disease (BRD) is a major problem in veal calf rearing units. The objective of this randomised clinical trial was to assess the... -
Melatonin receptor agonist protects against acute lung injury induced by vent...
Abstract Background It is well known that ventilation with high volume or pressure may damage healthy lungs or worsen injured lungs. Melatonin has been reported to be effective... -
Per-fraction positional and dosimetric performance of prone breast tangential...
Abstract Background This study investigates daily breast geometry and delivered dose to prone-positioned patients undergoing tangential whole breast radiation therapy (WBRT) on... -
Radiation dosimetry and biodistribution in non-human primates of the sodium/i...
Abstract Background [18F]-tetrafluoroborate is a PET radiotracer taken up by the sodium/iodide symporter (NIS). Albeit the in vivo behavior in rodents is similar to the... -
Cross-sectional survey on the use and impact of the Danish national antibioti...
Abstract Background The Danish antibiotic use guidelines for companion animal practice were published by the Danish Veterinary Association in 2012. Since then, national... -
Matrix-metalloproteinase-9 is cleaved and activated by Cathepsin K
Abstract Background Matrix-metalloproteinases 9 (MMP-9) belongs to the class of matrix metalloproteinases whose main function is to degrade and remodel the extracellular matrix...
