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Comparative analyses of the in vivo induction and transmission of α-synuclein...
Abstract α-synuclein (αS) is the major component of several types of brain pathological inclusions that define neurodegenerative diseases termed synucleinopathies. Central... -
Nanomedicine-driven neuropathic pain relief in a rat model is associated with...
Abstract We explored the immune neuropathology underlying multi-day relief from neuropathic pain in a rat model initiated at the sciatic nerve, by using a nanoemulsion-based... -
An interview study of pregnant women who were provided with indoor air qualit...
Abstract Background Maternal smoking can cause health complications in pregnancy. Particulate matter (PM2.5) metrics applied to second hand smoke (SHS) concentrations provide... -
Evaluating a process of academic detailing in primary care: an educational pr...
Abstract Background Primary care has a significant role in AKI management: two-thirds of AKI originates in the community. Through academic detailing (an evidence-based... -
Effect of exercise type on smoking cessation: a meta-analysis of randomized c...
Abstract Background Exercise is one choice of additional treatment for smoking cessation by relieving nicotine withdrawal symptoms and smoking craving. The possible mechanism of... -
Pharmacy employees’ involvement in safeguarding persons with dementia who use...
Abstract Background Community-dwelling persons with dementia commonly use dietary supplements (DS), often without receiving help with the administration. Patient safety is a... -
Treating tobacco dependence in older adults: a survey of primary care clinici...
Abstract Background The benefits of smoking cessation among older people are well documented. Despite this, evidence suggests that older smokers are rarely engaged in smoking... -
Defining the clinical pathway in cochrane diagnostic test accuracy reviews
Abstract Background The value of a medical test depends on the context in which it might be used. Ideally, questions, results and conclusions of a diagnostic test accuracy (DTA)... -
Effects of gestational diabetes mellitus on risk of adverse maternal outcomes...
Abstract Background Gestational diabetes mellitus is a leading medical condition woman encounter during pregnancy with serious short- and long-term consequences for maternal... -
Altered functional connectivity of the nucleus accumbens subdivisions in amph...
Abstract Background The growing abuse of amphetamine-type stimulants leads to new challenges to human health. A possible addiction mechanism has been proposed by altered... -
Hospital utilization rates following antipsychotic dose reductions: implicati...
Abstract Background Data are limited on the benefits and risks of dose reduction in managing side effects associated with antipsychotic treatment. As an example, antipsychotic... -
Vasoresponsiveness in patients with heart failure (VASOR): protocol for a pro...
Abstract Background Vasoplegia is a severe complication which may occur after cardiac surgery, particularly in patients with heart failure. It is a result of activation of... -
Evaluation in alcohol use disorders – insights from the nalmefene experience
Abstract Nalmefene was the first treatment approved by the European Medicines Agency for reducing alcohol consumption in adult patients with alcohol dependence. It is often... -
Degree of dyspnoea at admission and discharge in patients with heart failure ...
Abstract Background Dyspnoea is a disabling symptom in patients admitted with heart failure (HF) and respiratory diseases (RD). The main aim of this study is to evaluate its... -
Systematic review of outcome domains and instruments used in clinical trials ...
Abstract Background There is no evidence-based guidance to facilitate design decisions for confirmatory trials or systematic reviews investigating treatment efficacy for adults... -
Real world experience of patients with amyotrophic lateral sclerosis (ALS) in...
Background: Treatment of spasticity poses a major challenge in amyotrophic lateral sclerosis (ALS) patient management. Delta-9-tetrahydrocannabinol (THC):cannabidiol (CBD)... -
Work-related adverse events leaving their mark: a cross-sectional study among...
Abstract Background Health care professionals who are frequently coping with traumatic events have an increased risk of developing a posttraumatic stress disorder. Research... -
Combination of Ranibizumab with macular laser for macular edema secondary to ...
Abstract Background It is not clear whether macular laser combined with anti-vascular endothelial growth factor (VEGF) can reduce the number of anti-VEGF injections in the... -
Changing the Antibiotic Prescribing of general practice registrars: the ChAP ...
Abstract Background Australian General Practitioners (GPs) are generous prescribers of antibiotics, prompting concerns including increasing antimicrobial resistance in the... -
Influencing factors of physicians’ prescription behavior in selecting essenti...
Abstract Background To explore the key factors affecting prescription practices of essential medicines in Chinese county hospital. National essential medicine policy (NEMP)...
