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Unusual Transannular Cyclization Products of Sarcophytoxide, a 14-Membered Ma...
Treatment of sarcophytoxide with trimethylsilyl trifluoromethanesulfonate afforded an aromatic ketone as an unusual cyclization product. The modified Mosher's method and X-ray... -
Reactions of α,α‘-Dihydroxy Ketones with Phosgene. Structural Requirements fo...
α,α‘-Dihydroxy ketones having two OH groups that can come into close proximity react with phosgene in the presence of DMAP to produce 1,3-dioxane-2,5-diones. When covalent... -
Application of Stereoselective Ether Transfer to the Synthesis of Isotactic P...
An efficient, convergent synthetic strategy has been developed which enables the synthesis of a series of naturally occurring isotactic polymethoxy compounds. Ether transfer... -
Synthesis of Seven-Membered Cyclic Enol Ether Derivatives from the Reaction o...
The tandem Michael−intramolecular Wittig reactions of a five-membered cyclic phosphonium ylide (2) with α,β-unsaturated esters afforded seven-membered cyclic enol ether... -
Photoinduced Electron-Transfer Bicyclopropenyl-benzene Rearrangements of 2,2‘...
The 9,10-dicyanoanthracene-sensitized photoreaction of 1-methyl- and 1,1‘-dimethyl-2,2‘,3,3‘-tetraphenylbicyclopropenyl gives the corresponding benzene and Dewar benzene... -
An Efficient C−H Oxidation Protocol for α-Hydroxylation of Cyclic Steroidal E...
Various C-16 hydroxy steroids have been prepared with the aid of CrO3/Bu4NIO4. Out of the two possible reaction courses, transition state B is favored because of less steric... -
Microwave-Assisted Allylation of Acetals with Allyltrimethylsilane in the Pre...
We describe the first synthesis of homoallyl ethers from acetals and allyltrimethylsilane using microwave heating and CuBr as a promoter. This method works best for aromatic... -
Synthesis of Optically Active Vicinal Fluorohydrins by Lipase-Catalyzed Derac...
Three microbial lipases have been used to deracemize trans-2-fluorocycloalkanols 2 both by hydrolysis of the corresponding acetates 3 or chloroacetates 4 and by esterification... -
The Solid-Phase Zincke Reaction: Preparation of ω-Hydroxy Pyridinium Salts i...
A study of structural modifications of MPB-07 was undertaken as part of a synthetic program aimed at discovering small molecules with CFTR activation potential. Solid-phase... -
Mechanism of Metal Chloride-Promoted Mukaiyama Aldol Reactions
Ab initio calculations (MP2/6-311+G*//B3LYP/6-31G) were employed to investigate the mechanism of metal chloride-promoted Mukaiyama aldol reaction between trihydrosilyl enol... -
Thiacrown Ether Technology in Lipase-Catalyzed Reaction: Scope and Limitatio...
Both reaction rate and enantioselectivity in Pseudomonas cepacia lipase (PCL)-catalyzed hydrolysis of 3-hydroxyalkanenitrile acetates were significantly changed by the addition... -
Direct Electroreductive Preparation of Indolines and Indoles from Diazonium S...
Indolines and indoles are prepared for the first time by direct electrochemical reduction of arenediazonium salts. -
Solid-Phase Preparation of Dienes
The Stille reaction has been used to prepare a variety of functionalized dienes on a solid support. -
From Macrocycle Dipeptide Lactams To Azabicyclo[X.Y.0]alkanone Amino Acids: ...
Macrocyclic and fused bicyclic dipeptides are complementary motifs for mimicry of different types of β-turn geometry. Macrocyclic dipeptide mimics have served as precursors for... -
Domino Metathesis Involving ROM-RCM of Substituted Norbornenes. Rapid Access ...
Domino metathesis involving ROM-RCM of appropriately constructed norbornene derivatives having multiple alkene chains leads to direct access of highly functionalized bridged... -
Crown Ethers as Regulators of Enzymatic Reactions: Enhanced Reaction Rate an...
Both reaction rate and enantioselectivity in lipase-catalyzed hydrolysis of 2-cyano-1-methylethyl acetate were significantly changed by addition of some crown ethers. Although... -
Novel 1,4-Homofragmentation via an α-Lactone
Conversion of an α,α-dichloroester to the corresponding α-keto acid was unexpectedly complicated by a novel 1,4-homofragmentation. Investigation of the kinetics of this reaction... -
Ozonolyses of 3-Benzoyloxy- and 3-Trimethylsiloxy-Substituted 2-Phenylindenes...
Ozonolyses of 3-Benzoyloxy- and 3-Trimethylsiloxy-Substituted 2-Phenylindenes in Methanol: Substituent-Dependent Modes of Capture of the Carbonyl Oxide Intermediates by the... -
Bis Ring Closing Olefin Metathesis for the Synthesis of Unsaturated Polycycli...
Bis Ring Closing Olefin Metathesis for the Synthesis of Unsaturated Polycyclic Ethers. O-Membered Ring Cyclization in Favor of C-Membered Ring Cyclization
