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Design of Novel Derivatives of Phosphonoformate (Foscarnet) as Prodrugs and A...
Design of Novel Derivatives of Phosphonoformate (Foscarnet) as Prodrugs and Antiviral Agents -
Reactions of α,α‘-Dihydroxy Ketones with Phosgene. Structural Requirements fo...
α,α‘-Dihydroxy ketones having two OH groups that can come into close proximity react with phosgene in the presence of DMAP to produce 1,3-dioxane-2,5-diones. When covalent... -
A New Method for the Synthesis of Branched Polysilane Anions
Lithiation by MeLi of three families of branched polysilanes (Me3Si)3Si−X {(1) X = SiMe2H, t-BuMe2Si, SiMe2SiMe3, t-BuSiMe2SiMe2; (2) X = SiMe(SiMe3)2, Si(SiMe3)3,... -
Antimalarial Activity of a New Family of Analogues of Manzamine A
Manzamine A represents an important lead structure for the development of novel antimalarial chemotherapies. The synthesis and biological evaluation of a group of simplified... -
Application of Stereoselective Ether Transfer to the Synthesis of Isotactic P...
An efficient, convergent synthetic strategy has been developed which enables the synthesis of a series of naturally occurring isotactic polymethoxy compounds. Ether transfer... -
An Unusual Oxidative Cyclization: Studies towards the Biomimetic Synthesis o...
An unusual oxidative cyclization of a N-hydroxy pyridone 9 with Z-2-cyclodecenone 11 has been achieved, thus demonstrating a possible biomimetic route to pyridomacrolidin 2. -
Stereospecific Deoxygenation of Phosphine Oxides with Retention of Configurat...
A new protocol for deoxygenation of various phosphine oxides with retention of configuration is described. The advantage of the new method includes milder conditions and... -
Diphenylprolinol Methyl Ether: A Highly Enantioselective Catalyst for Michael...
Diphenylprolinol methyl ether catalyzes intermolecular Michael addition of simple aldehydes to relatively nonactivated enones with the highest enantioselectivities reported to... -
Copolymerization behavior of 7-methylene-2-methyl-1,5-dithiacyclooctane: Reve...
The copolymerization behavior of 7-methylene-2-methyl-1,5-dithiacyclooctane (MDTO) with a range of common comonomers has been investigated and found to be highly unusual. The... -
Bifunctional Organocatalyst for Activation of Carbon Dioxide and Epoxide To P...
Bifunctional organocatalysts bearing an ammonium betaine framework have been developed as a new catalytic motif for the activation of carbon dioxide and epoxides to produce... -
A New Family of Macrocycles Produced by Sequential Claisen−Schmidt Condensations
Members of a new family of macrocycles have been synthesized in one step, from simple building blocks, by sequential Claisen−Schmidt condensations. -
Absolute Configuration of Brevisamide and Brevisin: Confirmation of a Univers...
The discovery of brevisin, the first example of an “interrupted” polycyclic ether, obtained from the dinoflagellate Karenia brevis, posed some important questions regarding the... -
Unusual Cyclization Products Derived from Photolysis of Breslow's Steroidal B...
Unusual Cyclization Products Derived from Photolysis of Breslow's Steroidal Benzophenone Esters -
Core−Shell-Type Resins for Solid-Phase Peptide Synthesis: Comparison with Ge...
Novel core−shell-type resins with a rigid core and amino-functionalized flexible shell were prepared with 2,4,6-trichloro-1,3,5-triazine (CNC) and Jeffamine ED-600 starting from... -
Photoinduced Electron-Transfer Bicyclopropenyl-benzene Rearrangements of 2,2‘...
The 9,10-dicyanoanthracene-sensitized photoreaction of 1-methyl- and 1,1‘-dimethyl-2,2‘,3,3‘-tetraphenylbicyclopropenyl gives the corresponding benzene and Dewar benzene... -
An Efficient C−H Oxidation Protocol for α-Hydroxylation of Cyclic Steroidal E...
Various C-16 hydroxy steroids have been prepared with the aid of CrO3/Bu4NIO4. Out of the two possible reaction courses, transition state B is favored because of less steric... -
Chirally Modified Zeolites as Reaction Media: Photochemistry of an Achiral T...
Zeolites modified with chiral inductors serve as media for performing chiral induction during photochemical reactions of organic molecules. The photochemical behavior of achiral... -
Study on Photochromism of Diarylethenes with a 2,5-Dihydropyrrole Bridging Un...
Symmetric and nonsymmetric diarylethenes with a 2,5-dihydropyrrole bridging unit have been prepared, and the photochromic properties are investigated. Both symmetric and... -
Antiaromaticity in Distal Bisfluorenyl Dications Separated by Multiple Discre...
The effect of spacers on the antiaromaticity of bisfluorenyl dications was examined. For systems such as 4a−c in which extensive delocalization of the positive charge through... -
A Triple Diene-Transmissive Diels−Alder Strategy To Build the Quassinoid Fram...
An advanced intermediate to the highly oxygenated triterpene quassinoids was prepared in 14 steps from tetrahydrofuran. The key steps are three diene-transmissive Diels−Alder...
