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Design of Novel Derivatives of Phosphonoformate (Foscarnet) as Prodrugs and A...
Design of Novel Derivatives of Phosphonoformate (Foscarnet) as Prodrugs and Antiviral Agents -
Reactions of α,α‘-Dihydroxy Ketones with Phosgene. Structural Requirements fo...
α,α‘-Dihydroxy ketones having two OH groups that can come into close proximity react with phosgene in the presence of DMAP to produce 1,3-dioxane-2,5-diones. When covalent... -
Application of Stereoselective Ether Transfer to the Synthesis of Isotactic P...
An efficient, convergent synthetic strategy has been developed which enables the synthesis of a series of naturally occurring isotactic polymethoxy compounds. Ether transfer... -
An Unusual Oxidative Cyclization: Studies towards the Biomimetic Synthesis o...
An unusual oxidative cyclization of a N-hydroxy pyridone 9 with Z-2-cyclodecenone 11 has been achieved, thus demonstrating a possible biomimetic route to pyridomacrolidin 2. -
Stereospecific Deoxygenation of Phosphine Oxides with Retention of Configurat...
A new protocol for deoxygenation of various phosphine oxides with retention of configuration is described. The advantage of the new method includes milder conditions and... -
Core−Shell-Type Resins for Solid-Phase Peptide Synthesis: Comparison with Ge...
Novel core−shell-type resins with a rigid core and amino-functionalized flexible shell were prepared with 2,4,6-trichloro-1,3,5-triazine (CNC) and Jeffamine ED-600 starting from... -
Photoinduced Electron-Transfer Bicyclopropenyl-benzene Rearrangements of 2,2‘...
The 9,10-dicyanoanthracene-sensitized photoreaction of 1-methyl- and 1,1‘-dimethyl-2,2‘,3,3‘-tetraphenylbicyclopropenyl gives the corresponding benzene and Dewar benzene... -
An Efficient C−H Oxidation Protocol for α-Hydroxylation of Cyclic Steroidal E...
Various C-16 hydroxy steroids have been prepared with the aid of CrO3/Bu4NIO4. Out of the two possible reaction courses, transition state B is favored because of less steric... -
A Triple Diene-Transmissive Diels−Alder Strategy To Build the Quassinoid Fram...
An advanced intermediate to the highly oxygenated triterpene quassinoids was prepared in 14 steps from tetrahydrofuran. The key steps are three diene-transmissive Diels−Alder... -
The Solid-Phase Zincke Reaction: Preparation of ω-Hydroxy Pyridinium Salts i...
A study of structural modifications of MPB-07 was undertaken as part of a synthetic program aimed at discovering small molecules with CFTR activation potential. Solid-phase... -
Mechanism of Metal Chloride-Promoted Mukaiyama Aldol Reactions
Ab initio calculations (MP2/6-311+G*//B3LYP/6-31G) were employed to investigate the mechanism of metal chloride-promoted Mukaiyama aldol reaction between trihydrosilyl enol... -
Synthetic Applications of the Carbanion with a Fluoroalkyl Group generated by...
The generation and synthetic application of stable carbanions situated in the β position from fluorine atom(s) are described. Palladium(0)-catalyzed allylation reactions under... -
Controlling the Genotoxins Ethyl Chloride and Methyl Chloride Formed During t...
The genotoxins ethyl chloride (EtCl) and methyl chloride (MeCl) were generated during the preparation of the hydrochloride salts of two tertiary amines in the presence of... -
Variable Markovnikov Orientation and "cis Effect" in Ene Reactions of Nitroso...
Nitrosocarbonyl intermediates, generated at room temperature by the mild oxidation of nitrile oxides, undergo clean ene reactions with trisubstituted olefins. Allylic hydrogens... -
Asymmetric Catalytic Friedel−Crafts Reaction of Silyl Enol Ethers with Fluora...
The catalytic asymmetric Friedel−Crafts reaction of silyl enol ethers with fluoral proceeds under Mukaiyama-aldol conditions to give silyl enol ether products. The sequential... -
Solid-Phase Preparation of Dienes
The Stille reaction has been used to prepare a variety of functionalized dienes on a solid support. -
Competing Domino Processes: Path-Discriminating Ability of Epoxide Stereochem...
International audience; Structurally different products can be reached selectively from unsaturated vicinal bicyclic diols, which differ only by the epoxide configuration at the... -
From Macrocycle Dipeptide Lactams To Azabicyclo[X.Y.0]alkanone Amino Acids: ...
Macrocyclic and fused bicyclic dipeptides are complementary motifs for mimicry of different types of β-turn geometry. Macrocyclic dipeptide mimics have served as precursors for... -
Domino Metathesis Involving ROM-RCM of Substituted Norbornenes. Rapid Access ...
Domino metathesis involving ROM-RCM of appropriately constructed norbornene derivatives having multiple alkene chains leads to direct access of highly functionalized bridged... -
Ultrafast Reversible Photo-Cross-Linking Reaction: Toward in Situ DNA Manipul...
We describe a novel ultrafast reversible DNA interstrand photo-cross-linking reaction via 3-cyanovinylcarbazole nucleoside (CNVK). Oligodeoxynucleotide (ODN) containing CNVK can...
