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The pre-synaptic vesicle protein synaptotagmin is a novel biomarker for Alzhe...
Abstract Background Synaptic degeneration is a central pathogenic event in Alzheimer’s disease that occurs early during the course of disease and correlates with cognitive... -
Association of maternal ethnicity and urbanicity on severe pediatric disease:...
Abstract Background A healthy migrant effect on birth outcomes has been reported, however, whether this protective effect persists throughout childhood is unknown. The effect of... -
Diaper dermatitis: a survey of risk factors in Thai children aged under 24 mo...
Abstract Background To identify the prevalence and risk factors associated with diaper dermatitis in Thai children aged 1–24 months. Methods This was a cross-sectional study of... -
IgG4-related aortitis/periaortitis and periarteritis: a distinct spectrum of ...
Abstract Background Large vessels could be involved in immunoglobulin (Ig)-G4-related disease (IgG4-RD). This study aimed to clarify the clinical features and evaluate the... -
General practitioners’ continuation and acceptance of medication changes at s...
Abstract Background Follow-up in general practice on medication initiated during hospitalisation is often perceived to be inadequate, which leads to unintended drug interaction... -
Accelerating newborn survival in Ghana through a low-dose, high-frequency hea...
Abstract Background Newborn deaths comprise nearly half of under-5 deaths in Ghana, despite the fact that skilled birth attendants (SBAs) are present at 68% of births, which... -
Risk factors for death among children 0–59 months of age with moderate-to-sev...
Abstract Background Despite major improvements in child survival rates, the number of deaths due to diarrhea remains unacceptably high. We aimed to describe diarrhea-associated... -
Epidermal grafting versus split-thickness skin grafting for wound healing (EP...
Abstract Background Split-thickness skin grafting (SSG) is an important modality for wound closure. However, the donor site becomes a second, often painful wound, which may take... -
Hemodynamic impacts of flow diverter devices on the ophthalmic artery
Abstract Background Flow diverter devices are increasingly used for endovascular treatment of internal carotid artery aneurysms. Treatment of ophthalmic segment aneurysms with... -
The effect of the Xpert MTB/RIF test on the time to MDR-TB treatment initiati...
Abstract Background There are significant delays in initiation of multidrug-resistant tuberculosis (MDR –TB) treatment. The Xpert MTB/RIF test has been shown to reduce the time... -
Initial nutritional management during noninvasive ventilation and outcomes: a...
Abstract Background Patients starting noninvasive ventilation (NIV) to treat acute respiratory failure are often unable to eat and therefore remain in the fasting state or... -
Delay in diagnosis of pulmonary tuberculosis increases the risk of pulmonary ...
Abstract Background Delay in diagnosis and treatment of pulmonary tuberculosis (PTB) leads to severe disease, adverse outcomes and increased transmission. Assessing the extent... -
Does the transfer of a poor quality embryo with a good quality embryo benefit...
Abstract Background While single embryo transfer (SET) is widely advocated, double embryo transfer (DET) remains preferable in clinical practice to improve IVF success rate,... -
Parental concerns and uptake of childhood vaccines in rural Tanzania – a mixe...
Abstract Background Vaccine hesitancy has been recognized as an important barrier to timely vaccinations around the world, including in sub-Saharan Africa. In Tanzania, 1 in 4... -
Risk factors for possible serious bacterial infection in a rural cohort of yo...
Abstract Background Possible serious bacterial infection (PBSI) is a major cause of neonatal mortality worldwide. We studied risk factors for PSBI in a large rural population in... -
Using the missed opportunity tool as an application of the Lives Saved Tool (...
Abstract Background The Missed Opportunity tool was developed as an application in the Lives Saved Tool (LiST) to allow users to quickly compare the relative impact of... -
Development and validation of a variant detection workflow for BRCA1 and BRCA...
Abstract Background Breast cancer is the most common among women worldwide, and ovarian cancer is the most difficult gynecological tumor to diagnose and with the lowest chance... -
Polygenic risk for coronary heart disease acts through atherosclerosis in typ...
Abstract Background Type 2 diabetes increases the risk of coronary heart disease (CHD), yet the mechanisms involved remain poorly described. Polygenic risk scores (PRS) provide... -
Identification and validation of a Schistosoma japonicum U6 promoter
Abstract Background RNA polymerase III promoters have been widely used to express short hairpin-RNA (shRNA), microRNA (miRNA), and small guide RNA (sgRNA) in gene functional... -
eRegistries: indicators for the WHO Essential Interventions for reproductive,...
Abstract Background Electronic health registries â eRegistries - can systematically collect relevant information at the point of care for reproductive, maternal, newborn and...
