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Module and individual domain deletions of NRPS to produce plipastatin derivat...
Abstract Background Plipastatin, an antifungal lipopeptide, is synthesized by a non-ribosomal peptide synthetase (NRPS) in Bacillus subtilis. However, little information is... -
Fecal metatranscriptomics of macaques with idiopathic chronic diarrhea reveal...
Abstract Background Idiopathic chronic diarrhea (ICD) is a common cause of morbidity and mortality among juvenile rhesus macaques. Characterized by chronic inflammation of the... -
Prediction of advanced colonic neoplasm in symptomatic patients: a scoring sy...
Abstract Background Fast-track colonoscopy to detect patients with colorectal cancer based on high-risk symptoms is associated with low sensitivity and specificity. The aim was... -
Optimization of cellulolytic enzyme components through engineering Trichoderm...
Abstract Background Cellulolytic enzymes produced by Trichoderma reesei are widely studied for biomass bioconversion, and enzymatic components vary depending on different... -
Improving squalene production by enhancing the NADPH/NADP+ ratio, modifying t...
Abstract Background Squalene is currently used widely in the food, cosmetics, and medicine industries. It could also replace petroleum as a raw material for fuels. Microbial... -
An efficient modified method for plant leaf lipid extraction results in impro...
Abstract Background Lipidomics plays an important role in understanding plant adaptation to different stresses and improving our knowledge of the genes underlying lipid... -
The Ussing chamber system for measuring intestinal permeability in health and...
Abstract Background The relationship between intestinal epithelial integrity and the development of intestinal disease is of increasing interest. A reduction in mucosal... -
Enzyme adsorption-induced activity changes: a quantitative study on TiO2 mode...
Abstract Background Activity retention upon enzyme adsorption on inorganic nanostructures depends on different system parameters such as structure and composition of the... -
Bi-Assisted CdTe/CdS Hierarchical Nanostructure Growth for Photoconductive Ap...
Abstract We developed a method to control the structure of CdTe nanowires by adopting Bi-mixed CdTe powder source to a catalyst-assisted chemical vapor deposition, which allowed... -
Synthetic control devices for gene regulation in Penicillium chrysogenum
Abstract Background Orthogonal, synthetic control devices were developed for Penicillium chrysogenum, a model filamentous fungus and industrially relevant cell factory. In the... -
Efficient and mild swern oxidation using a new sulfoxide and <i>bis</i>(trich...
A new type of sulfoxide, 4-(2-(2-(methylsulfinyl) ethyl)-4-nitrophenyl)- morpholine (I) was designed and prepared in good yield. Upon the combination of I andbis... -
Real-time tracking of complex ubiquitination cascades using a fluorescent con...
Abstract Background The ubiquitin-proteasome system (UPS) controls the stability, localization and/or activity of the proteome. However, the identification and characterization... -
Hyper-accurate flexible calibration technique for fringe-projection-based thr...
Fringe-projection-based (FPB) three-dimensional (3D) imaging technique has become one of the most prevalent methods for 3D shape measurement and 3D image acquisition, and an... -
A novel biocatalyst, Enterobacter aerogenes LU2, for efficient production of ...
Abstract Background Succinic acid (SA), a valuable chemical compound with a broad range of industrial uses, has become a subject of global interest in recent years. The... -
Role of mesenchymal stem cells, their derived factors, and extracellular vesi...
Abstract Liver failure is a severe clinical syndrome with a poor prognosis. Mesenchymal stem cell (MSC) transplantation has emerged as a new intervention in treating liver... -
Metabolic engineering of indole pyruvic acid biosynthesis in Escherichia coli...
Abstract Background Indole pyruvic acid (IPA) is a versatile platform intermediate and building block for a number of high-value products in the pharmaceutical and food... -
Engineering Saccharomyces cerevisiae with the deletion of endogenous glucosid...
Abstract Background Glycosylation of flavonoids is a promising approach to improve the pharmacokinetic properties and biological activities of flavonoids. Recently, many efforts... -
Metabolic flux analysis for metabolome data validation of naturally xylose-fe...
Abstract Background Efficient xylose fermentation still demands knowledge regarding xylose catabolism. In this study, metabolic flux analysis (MFA) and metabolomics were used to... -
Data integration to prioritize drugs using genomics and curated data
Abstract Background Genomic alterations affecting drug target proteins occur in several tumor types and are prime candidates for patient-specific tailored treatments.... -
Synthesis of (1E,3E)-1,4-diarylbuta-1,3-dienes promoted by μ-OMs palladium–di...
Abstract A convenient approach for (1E,3E)-1,4-diarylbuta-1,3-dienes via intermolecular Heck reaction of olefins and β-bromostyrenes promoted by μ-OMs palladium–dimer complex...
