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Omalizumab in patients with severe asthma and persistent sputum eosinophilia
Abstract Omalizumab, a recombinant humanized monoclonal antibody targeting the IgE molecule, is the first biologic approved for moderate-to-severe allergic asthmatics, who... -
Effects of the Toll-like receptor 7 (TLR7) agonist, AZD8848, on allergen-indu...
Abstract Background Although allergic asthma is a complex area with many interacting factors involved, the ‘hygiene hypothesis’ proposes that a lack of exposure to infection... -
Excessive carbohydrate consumption and body mass index: the risk factors for ...
Abstract Background Prader-Willi syndrome (PWS) is commonly associated with severe obesity and type 2 diabetes mellitus (T2DM) and is caused by excessive eating. Only very few... -
Nanomedicine-driven neuropathic pain relief in a rat model is associated with...
Abstract We explored the immune neuropathology underlying multi-day relief from neuropathic pain in a rat model initiated at the sciatic nerve, by using a nanoemulsion-based... -
Dexketoprofen/tramadol 25 mg/75 mg: randomised double-blind trial in moderate...
Abstract Background Dexketoprofen trometamol plus tramadol hydrochloride is a new oral combination of two analgesics, which have different mechanisms of action for the treatment... -
Repeated social defeat promotes persistent inflammatory changes in splenic my...
Abstract Background Previous studies suggest that persistent exposure to social stress in mammals may be associated with multiple physiological effects. Here, we examine the... -
The whole - genome expression analysis of peripheral blood mononuclear cells ...
Abstract Background Up to 30 % of adults with severe asthma are hypersensitive to aspirin and no unambiguous theory exists which provides a satisfactory explanation for the... -
Resveratrol mediates mechanical allodynia through modulating inflammatory res...
Abstract Background Neuropathic pain (NeuP) is a chronic and challenging clinical problem, with little effective treatment. Resveratrol has shown neuroprotection by inhibiting... -
Identification of plasma microRNA expression changes in multiple system atrop...
Abstract MicroRNAs (miRNAs) are endogenous small (18–25 nt), single-stranded, non-coding RNAs that play key roles in post-transcriptional gene expression regulation. The... -
Relationship between age and bronchodilator response at diagnosis in adult-on...
Abstract Background Possible variation in bronchodilator response (BDR) according to age at the diagnosis of adult-onset asthma is unknown. Our aim was to assess if BDR in FEV1... -
Transcriptomic data from two primary cell models stimulating human monocytes ...
Abstract Background Biological interpretation of DNA microarray data may differ depending on underlying assumptions and statistical tests of bioinformatics tools used. We used... -
Genome-wide recruitment profiling of transcription factor Crz1 in response to...
Abstract Background Exposure of the budding Saccharomyces cerevisiae to an alkaline environment produces a robust transcriptional response involving hundreds of genes. Part of... -
Distribution of nickel and chromium containing particles from tattoo needle w...
Abstract Background Allergic reactions to tattoos are amongst the most common side effects occurring with this permanent deposition of pigments into the dermal skin layer. The... -
The impairment of small nerve fibers in severe sepsis and septic shock
Abstract Background A decrease of small nerve fibers in skin biopsies during the course of critical illness has been demonstrated recently. However, the diagnostic use of skin... -
The effects of green cardamom on blood glucose indices, lipids, inflammatory ...
Abstract Background The relationship between dietary components and nonalcoholic fatty liver disease (NAFLD) needs to be further investigated. The potential health benefits of... -
Aberrant activation of NF-κB signaling in mammary epithelium leads to abnorma...
Abstract Background Approximately 1 in 5 women diagnosed with breast cancer are considered to have in situ disease, most often termed ductal carcinoma in situ (DCIS). Though... -
Feasibility and acceptance of exercise recommendations (10,000 steps a day) w...
Abstract Background Benefits of exercise to prevent non-communicable diseases are well-documented. Limited data exists to promote physical activity in healthy but sedentary... -
Preemptive intrathecal administration of endomorphins relieves inflammatory p...
Abstract Background Preemptive administration of analgesic drugs reduces perceived pain and prolongs duration of antinociceptive action. Whereas several lines of evidence... -
Supplement of microbiota-accessible carbohydrates prevents neuroinflammation ...
Abstract Background Western pattern diets induce neuroinflammation and impair cognitive behavior in humans and animals. Neuroinflammation and cognitive impairment have been... -
Sex-specific IL-6-associated signaling activation in ozone-induced lung infla...
Abstract Background Acute ozone (O3) exposure has known deleterious effects on the respiratory system and has been linked with respiratory disease and infection. Inflammatory...
