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Retrospective analysis in oculocutaneous albinism patients for the 2.7 kb del...
Abstract Background Oculocutaneous albinism (OCA) is an autosomal recessive disorder. A significant portion of OCA patients has been found with a single pathogenic variant... -
Periostin involved in the activated hepatic stellate cells-induced progressio...
Abstract Background Incomplete thermal ablation may induce invasiveness of hepatocellular carcinoma (HCC). Here, we investigated whether activated hepatic stellate cells (HSCs)... -
Human-like NSG mouse glycoproteins sialylation pattern changes the phenotype ...
Abstract Background The use of immunodeficient mice transplanted with human hematopoietic stem cells is an accepted approach to study human-specific infectious diseases such as... -
Identification and validation of a Schistosoma japonicum U6 promoter
Abstract Background RNA polymerase III promoters have been widely used to express short hairpin-RNA (shRNA), microRNA (miRNA), and small guide RNA (sgRNA) in gene functional... -
Development and validation of a novel PCR-RFLP based method for the detection...
Abstract Background Leber’s Hereditary Optic Neuropathy (LHON; MIM 535000) is one of the most commonly inherited optic neuropathies and it results in significant visual... -
Dipeptidyl peptidase-4 is highly expressed in bronchial epithelial cells of u...
Abstract Background Type 2 helper T-cell cytokines including IL-13 play a central role in the pathogenesis of bronchial asthma (BA). During the course of our research, our... -
The source of circulating selenoprotein S and its association with type 2 dia...
Abstract Background Selenoprotein S (SelS) is a transmembrane protein that is expressed in the liver, skeletal muscle, adipose tissue, pancreatic islets, kidney, and blood... -
Overexpression of MALT1-A20-NF-κB in adult B-cell acute lymphoblastic leukemia
Abstract Background A20 is a dual inhibitor of NF-κB activation and apoptosis in the tumor necrosis factor receptor 1 signaling pathway, and both are related to tumorigenesis.... -
Evaluating the efficacy of dexamethasone in the treatment of patients with pe...
Abstract Background Although much has evolved in our understanding of the pathogenesis and factors affecting outcome of patients with acute respiratory distress syndrome (ARDS),... -
Bacillus subtilis 5′-nucleotidases with various functions and substrate speci...
Abstract Background In Escherichia coli, nagD, yrfG, yjjG, yieH, yigL, surE, and yfbR encode 5′-nucleotidases that hydrolyze the phosphate group of 5′-nucleotides. In Bacillus... -
Post renal transplant anemia: severity, causes and their association with gra...
Abstract Background Post transplantation anemia (PTA) is common among kidney transplant patients. PTA is associated with increased graft loss and in most studies with increased... -
Medication use in juvenile uveitis patients enrolled in the Childhood Arthrit...
Abstract Background There is not yet a commonly accepted, standardized approach in the treatment of juvenile idiopathic uveitis when initial steroid therapy is insufficient. We... -
Etoposide induces cell death via mitochondrial-dependent actions of p53
Abstract Background Etoposide has been used clinically in cancer treatment, as well as in numerous research studies, for many years. However, there is incomplete information... -
Inflammatory anemia-associated parameters are related to 28-day mortality in ...
Abstract Background Anemia is one of the most common complications of sepsis. Sepsis-related anemia is associated mainly with inflammation. We aimed to observe the changes in... -
SAMHD1 specifically restricts retroviruses through its RNase activity
Abstract Background Human SAMHD1 possesses dual enzymatic functions. It acts as both a dGTP-dependent triphosphohydrolase and as an exoribonuclease. The dNTPase function... -
Pathogen-regulated genes in wheat isogenic lines differing in resistance to b...
Abstract Background Inoculation of wheat plants with Puccinia triticina (Pt) spores activates a wide range of host responses. Compatible Pt interaction with susceptible Thatcher... -
A self-marker-like protein governs hemocyte allorecognition in Halocynthia ro...
Abstract Background Self-incompatibility, fusion/non-fusion reactions, and contact reactions (CRs) have all been identified as allorecognition phenomena in ascidians. CR is a... -
A novel Sugarcane bacilliform virus promoter confers gene expression preferen...
Abstract Background Saccharum species such as sugarcane and energy cane are key players in the expanding bioeconomy for sugars, bioenergy, and production of high-value proteins....
