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The ameliorative effect of monotropein, astragalin, and spiraeoside on oxidat...
Abstract Background Monotropein, astragalin, and spiraeoside (MAS) are active compounds extracted from medicinal herbs; monotropein from Morinda officinalis How (Rubiaceae),... -
Development of a new promoter to avoid the silencing of genes in the producti...
Abstract Background The production of recombinant proteins in mammalian cell lines is one of the most important areas in biopharmaceutical industry. Viral transcriptional... -
Isolation and functional validation of the CmLOX08 promoter associated with s...
Abstract Background Lipoxygenases (LOXs) play significant roles in abiotic stress responses, and identification of LOX gene promoter function can make an important contribution... -
Loki zupa alleviates inflammatory and fibrotic responses in cigarette smoke i...
Abstract Background Loki zupa formula is kind of a traditional medicines which used to treat airway diseases, especially those caused by abnormal phlegm, such as cough, asthma... -
Suppression of MyD88-dependent signaling alleviates neuropathic pain induced ...
Abstract Background MyD88 is the adaptor protein of MyD88-dependent signaling pathway of TLRs and IL-1 receptor and regulates innate immune response. However, it was not clear... -
Activated spinal astrocytes contribute to the later phase of carrageenan-indu...
Abstract Background Prostatodynia is the main symptom of chronic prostatitis and the main reason that patients go to the hospital for treatment. Although a variety of factors,... -
Monocarboxylate transporter 1 promotes classical microglial activation and pr...
Abstract Background Microglia, the resident macrophages of central nervous system, have been initially categorized into two opposite phenotypes: classical activation related to... -
Tumor-suppressor role of miR-139-5p in endometrial cancer
Abstract Background Endometrial cancer (EC) is the fourth most common malignancy of the female genital tract worldwide. MicroRNAs are important gene regulators with critical... -
Additional file 1: of The prominent alteration in transcriptome and metabolom...
Table S1. The complete list of differentially expressed genes in control and VB1-treated samples. (XLS 111 kb) -
Electrical interferential current stimulation versus electrical acupuncture i...
Abstract Background Hemiplegic Shoulder Pain (HSP) is among common complications occurring after stroke leading to disability. This study was conducted to compare the effects of... -
Parity predisposes breasts to the oncogenic action of PAPP-A and activation o...
Abstract Background Women who had children at a young age (less than 25) show a reduced overall risk of breast cancer. However, epidemiological studies showed that for all other... -
Crosstalk between NFκB-dependent astrocytic CXCL1 and neuron CXCR2 plays a ro...
Abstract Background Despite accumulating evidence on the role of glial cells and their associated chemicals in mechanisms of pain, few studies have addressed the potential role... -
Radio-detoxified LPS alters bone marrow-derived extracellular vesicles and en...
Abstract Stem cell-based therapies raise hope for cell replacement and provide opportunity for cardiac regenerative medicine and tumor therapy. Extracellular vesicles are a... -
Ketamine-induced apoptosis in the mouse cerebral cortex follows similar chara...
Abstract The effects of general anesthetics on inducing neuronal apoptosis during early brain development are well-documented. However, since physiological apoptosis also occurs... -
Changes in circulating cell-free nuclear DNA and mitochondrial DNA of patient...
Abstract Background Adolescent idiopathic scoliosis (AIS) which characterized by complex three-dimensional deformity of spine has been difficult to cure because of the unknown... -
Polygenic risk for coronary heart disease acts through atherosclerosis in typ...
Abstract Background Type 2 diabetes increases the risk of coronary heart disease (CHD), yet the mechanisms involved remain poorly described. Polygenic risk scores (PRS) provide... -
Oligo-carrageenan kappa increases glucose, trehalose and TOR-P and subsequent...
Abstract Background It has been previously shown that oligo-carrageenan (OC) kappa increases growth, photosynthesis and activities of enzymes involved in basal and secondary... -
Light-induced gene expression with photocaged IPTG for induction profiling in...
Abstract Background Inducible expression systems are frequently used for the production of heterologous proteins. Achieving maximum product concentrations requires induction... -
NADPH oxidases as potential pharmacological targets against increased seizure...
Abstract Background Systemic inflammation associated with sepsis can induce neuronal hyperexcitability, leading to enhanced seizure predisposition and occurrence. Brain... -
Identification and validation of a Schistosoma japonicum U6 promoter
Abstract Background RNA polymerase III promoters have been widely used to express short hairpin-RNA (shRNA), microRNA (miRNA), and small guide RNA (sgRNA) in gene functional...
