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Reduced expression of miR-146a in human bronchial epithelial cells alters neu...
Abstract Background The role of miRNAs in the pathogenesis and determining the phenotypes of asthma is not fully elucidated. miR-146a has been previously shown to suppress... -
Prenatal smoking exposure and neuropsychiatric comorbidity of ADHD: a finnish...
Abstract Background Prenatal smoking exposure has been associated with attention-deficit/hyperactivity disorder (ADHD). ADHD is commonly associated with a wide spectrum of... -
Inflammatory interferon activates HIF-1α-mediated epithelial-to-mesenchymal t...
Abstract Background Tumor microenvironments (TMEs) activate various axes/pathways, predominantly inflammatory and hypoxic responses, impact tumorigenesis, metastasis and... -
FABP4 promotes invasion and metastasis of colon cancer by regulating fatty ac...
Abstract Background The prognosis of colon cancer is poor for metastasis, while the mechanism, especially adipocytes related, is not yet clear. The purpose of this study is to... -
TBCRC 002: a phase II, randomized, open-label trial of preoperative letrozole...
Abstract Background In preclinical studies, the expression of vascular endothelial growth factor (VEGF) in hormone receptor-positive breast cancer is associated with... -
Dietary supplement of Smilax china L. ethanol extract alleviates the lipid ac...
Abstract Background Obesity has become a public health concern worldwide because it is linked to numerous metabolic disorders, such as hyperlipidemia, hypertension and... -
The human fetal adrenal produces cortisol but no detectable aldosterone throu...
Abstract Background Human fetal adrenal glands are highly active and, with the placenta, regulate circulating progesterone, estrogen and corticosteroids in the fetus. At birth... -
11β-HSD1 plays a critical role in trabecular bone loss associated with system...
Abstract Background Despite their efficacy in the treatment of chronic inflammation, the prolonged application of therapeutic glucocorticoids (GCs) is limited by significant... -
Clinical and subclinical endometritis induced alterations in bovine endometri...
Abstract Background Clinical and subclinical endometritis are known to affect the fertility of dairy cows by inducing uterine inflammation. We hypothesized that clinical or... -
Comparative transcriptome profiling of two Brassica napus cultivars under chr...
Abstract Background Chromium (Cr) being multifarious industrial used element, is considered a potential environmental threat. Cr found to be a prospective water and soil... -
Regulatory role of capsaicin-sensitive peptidergic sensory nerves in the prot...
Abstract Objective The regulatory role of capsaicin-sensitive peptidergic sensory nerves has been shown in acute inflammation, but little is known about their involvement in... -
Tumor-associated neutrophils induce EMT by IL-17a to promote migration and in...
Abstract Purpose Epithelial to mesenchymal transition (EMT) can contribute to gastric cancer (GC) progression and recurrence following therapy. Tumor-associated neutrophils... -
Thymic carcinoma metastasize to the small intestine: a case report
Abstract Background Thymic carcinoma is a rare mediastinal neoplasm with a high malignant potential. It often shows pleural invasion and distant metastasis. The metastasis of... -
Grape seed-derived procyanidins alleviate gout pain via NLRP3 inflammasome su...
Abstract Background Gout is one of the common inflammatory arthritis which affects many people for inflicting unbearable pain. Macrophage-mediated inflammation plays an... -
Insulinlike Growth Factor (IGF)-1 Administration Ameliorates Disease Manifest...
Abstract Spinal and bulbar muscular atrophy is an X-linked motor neuron disease caused by polyglutamine expansion in the androgen receptor. Patients develop slowly progressive... -
IL-10/STAT3 is reduced in childhood obesity with hypertriglyceridemia and is ...
Abstract Background The prevalence of childhood obesity and obesity-related metabolic disorder such as dyslipidemia has sharply increased in the past few decades. Chronic... -
Tamoxifen in Duchenne muscular dystrophy (TAMDMD): study protocol for a multi...
Abstract Background Duchenne muscular dystrophy (DMD) is an inherited neuromuscular disorder of childhood with a devastating disease course. Several targeted gene therapies and... -
The protective effects of Resveratrol against radiation-induced intestinal in...
Abstract Background Intestinal injury is a potential cause of death after high-dose radiation exposure. The aim of the present study was to investigate the protective effects of... -
Forkhead Box F1 promotes breast cancer cell migration by upregulating lysyl o...
Abstract Background Epithelial-mesenchymal transition (EMT) increases cell migration and is implicated in cancer cell invasion and metastasis. We have previously described the... -
Epigenetic suppression of liver X receptor β in anterior cingulate cortex by ...
Abstract Background Liver X receptors (LXRs), including LXRα and LXRβ, are key regulators of transcriptional programs for both cholesterol homeostasis and inflammation in the...
