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The pentose phosphate pathway regulates chronic neuroinflammation and dopamin...
Abstract Background Metabolic dysfunction and neuroinflammation are increasingly implicated in Parkinson’s disease (PD). The pentose phosphate pathway (PPP, a metabolic pathway... -
Disrupting USP5/Cav3.2 interactions protects female mice from mechanical hype...
Abstract Cav3.2Â T-type calcium channels are important for the signaling of nociceptive information in the primary afferent pain pathway. During neuropathy and peripheral... -
MicroRNA-181a as novel liquid biopsy marker of central nervous system involve...
Abstract Background Refractory central nervous system (CNS) involvement is among the major causes of therapy failure in childhood acute leukemia. Applying contemporary... -
Epidermal growth factor prevents APOE4 and amyloid-beta-induced cognitive and...
Abstract Cerebrovascular (CV) dysfunction is emerging as a critical component of Alzheimer’s disease (AD), including altered CV coverage. Angiogenic growth factors (AGFs) are... -
Retinoid acid-induced microRNA-31-5p suppresses myogenic proliferation and di...
Abstract Background We previously reported that Wnt5a/CaMKIIδ (calcium/calmodulin-dependent protein kinase II delta) pathway was involved in the embryonic tongue deformity... -
Blood transfusion improves renal oxygenation and renal function in sepsis-ind...
Abstract Background The effects of blood transfusion on renal microcirculation during sepsis are unknown. This study aimed to investigate the effect of blood transfusion on... -
Heat shock protein 60 (HSP60) modulates adiponectin signaling by stabilizing ...
Abstract Adiponectin, an adipokine produced and secreted by adipocytes, is involved in regulating the development and progression of insulin resistance, diabetes, and diabetic... -
Transcriptomic analysis of mouse liver reveals a potential hepato-enteric pat...
Abstract Background Toxoplasma gondii is a worldwide spread pathogen which can infect all tissues of its host. The transcriptomic responses of infected brain and spleen have... -
JMJD2C promotes colorectal cancer metastasis via regulating histone methylati...
Abstract Background Our previous work demonstrated that lncRNA-MALAT1 was overexpressed in recurrent colorectal cancer (CRC) and metastatic sites in post-surgical patients.... -
Increased mortality of acute respiratory distress syndrome was associated wit...
Abstract Background There is a dearth of drug therapies available for the treatment of acute respiratory distress syndrome (ARDS). Certain metabolites play a key role in ARDS... -
Impact of body mass index and fat distribution on sex steroid levels in endom...
Abstract Background Obesity is an important cause of multiple cancer types, amongst which endometrial cancer (EC). The relation between obesity and cancer is complicated and... -
Oxysterol levels and metabolism in the course of neuroinflammation: insights ...
Abstract Background Oxysterols are cholesterol derivatives that have been suggested to play a role in inflammatory diseases such as obesity, atherosclerosis, or... -
Improved co-registration of ex-vivo and in-vivo cardiovascular magnetic reson...
Abstract Background Ex-vivo cardiovascular magnetic resonance (CMR) imaging has played an important role in the validation of in-vivo CMR characterization of pathological... -
Evidence of cAMP involvement in cellobiohydrolase expression and secretion by...
Abstract Background The signaling second messenger cyclic AMP (cAMP) regulates many aspects of cellular function in all organisms. Previous studies have suggested a role for... -
Simvastatin and a Plant Galactolipid Protect Animals from Septic Shock by Reg...
Abstract Sepsis remains a major medical issue despite decades of research. Identification of important inflammatory cascades and key molecular mediators are crucial for... -
MiR-21-5p regulates extracellular matrix degradation and angiogenesis in TMJO...
Abstract Background Due to the lack of research on the pathological mechanism of temporomandibular joint osteoarthritis (TMJOA), there are few effective treatment measures in... -
miR-140-5p regulates the odontoblastic differentiation of dental pulp stem ce...
Abstract Background MicroRNAs (miRNAs) play a key role in regulating cell differentiation. In the present study, we aimed to explore the role of miR-140-5p in odontoblastic... -
Thrombin-induced, TNFR-dependent miR-181c downregulation promotes MLL1 and NF...
Abstract Background Controlling thrombin-driven microglial activation may serve as a therapeutic target for intracerebral hemorrhage (ICH). Here, we investigated microRNA... -
Andrographolide induces Nrf2 and heme oxygenase 1 in astrocytes by activating...
Abstract Background Andrographolide is the major labdane diterpenoid originally isolated from Andrographis paniculata and has been shown to have anti-inflammatory and... -
Nur77-mediated TRAF6 signalling protects against LPS-induced sepsis in mice
Abstract Background Nur77, a key member of the NR4A receptor subfamily, is involved in the regulation of inflammation and immunity. However, the in vivo regulatory roles of...
