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Lipopolysaccharide-induced neuroinflammation induces presynaptic disruption t...
Abstract Background Systemic inflammation has been linked to synapse loss and cognitive decline in human patients and animal models. A role for microglial release of... -
Association of adipokines with blood pressure, arterial elasticity and cardia...
Abstract Background Adipokines are a set of cytokines secreted by white adipose tissue that have been suggested to be involved in the development of cardiovascular diseases. We... -
IL-6 rs1800795 polymorphism is associated with septic shock-related death in ...
Abstract Background Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection, being the primary cause of death from infection,... -
Mesenchymal stem cell-derived exosomal microRNA-136-5p inhibits chondrocyte d...
Abstract Background Emerging evidence suggests that microRNAs (miRs) are associated with the progression of osteoarthritis (OA). In this study, the role of exosomal miR-136-5p... -
Effects of cigarette smoke on barrier function and tight junction proteins in...
Abstract Background Airway epithelial barrier function is maintained by the formation of tight junctions (TJs) and adherens junctions (AJs). Inhalation of cigarette smoke causes... -
Prenatal smoking exposure and neuropsychiatric comorbidity of ADHD: a finnish...
Abstract Background Prenatal smoking exposure has been associated with attention-deficit/hyperactivity disorder (ADHD). ADHD is commonly associated with a wide spectrum of... -
TBCRC 002: a phase II, randomized, open-label trial of preoperative letrozole...
Abstract Background In preclinical studies, the expression of vascular endothelial growth factor (VEGF) in hormone receptor-positive breast cancer is associated with... -
The human fetal adrenal produces cortisol but no detectable aldosterone throu...
Abstract Background Human fetal adrenal glands are highly active and, with the placenta, regulate circulating progesterone, estrogen and corticosteroids in the fetus. At birth... -
11β-HSD1 plays a critical role in trabecular bone loss associated with system...
Abstract Background Despite their efficacy in the treatment of chronic inflammation, the prolonged application of therapeutic glucocorticoids (GCs) is limited by significant... -
Clinical and subclinical endometritis induced alterations in bovine endometri...
Abstract Background Clinical and subclinical endometritis are known to affect the fertility of dairy cows by inducing uterine inflammation. We hypothesized that clinical or... -
Regulatory role of capsaicin-sensitive peptidergic sensory nerves in the prot...
Abstract Objective The regulatory role of capsaicin-sensitive peptidergic sensory nerves has been shown in acute inflammation, but little is known about their involvement in... -
Grape seed-derived procyanidins alleviate gout pain via NLRP3 inflammasome su...
Abstract Background Gout is one of the common inflammatory arthritis which affects many people for inflicting unbearable pain. Macrophage-mediated inflammation plays an... -
Insulinlike Growth Factor (IGF)-1 Administration Ameliorates Disease Manifest...
Abstract Spinal and bulbar muscular atrophy is an X-linked motor neuron disease caused by polyglutamine expansion in the androgen receptor. Patients develop slowly progressive... -
Tamoxifen in Duchenne muscular dystrophy (TAMDMD): study protocol for a multi...
Abstract Background Duchenne muscular dystrophy (DMD) is an inherited neuromuscular disorder of childhood with a devastating disease course. Several targeted gene therapies and... -
Epigenetic suppression of liver X receptor β in anterior cingulate cortex by ...
Abstract Background Liver X receptors (LXRs), including LXRα and LXRβ, are key regulators of transcriptional programs for both cholesterol homeostasis and inflammation in the... -
Loki zupa alleviates inflammatory and fibrotic responses in cigarette smoke i...
Abstract Background Loki zupa formula is kind of a traditional medicines which used to treat airway diseases, especially those caused by abnormal phlegm, such as cough, asthma... -
Monocarboxylate transporter 1 promotes classical microglial activation and pr...
Abstract Background Microglia, the resident macrophages of central nervous system, have been initially categorized into two opposite phenotypes: classical activation related to... -
Electrical interferential current stimulation versus electrical acupuncture i...
Abstract Background Hemiplegic Shoulder Pain (HSP) is among common complications occurring after stroke leading to disability. This study was conducted to compare the effects of... -
Radio-detoxified LPS alters bone marrow-derived extracellular vesicles and en...
Abstract Stem cell-based therapies raise hope for cell replacement and provide opportunity for cardiac regenerative medicine and tumor therapy. Extracellular vesicles are a... -
Ketamine-induced apoptosis in the mouse cerebral cortex follows similar chara...
Abstract The effects of general anesthetics on inducing neuronal apoptosis during early brain development are well-documented. However, since physiological apoptosis also occurs...
