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ERα-36 regulates progesterone receptor activity in breast cancer
Abstract Background Alterations in estrogen and progesterone signaling, via their respective receptors, estrogen receptor alpha (ERα) and progesterone receptor (PR),... -
Highly active promoters and native secretion signals for protein production d...
Abstract Background The filamentous ascomycete Aspergillus niger is used in many industrial processes for the production of enzymes and organic acids by batch and fed-batch... -
Untargeted metabolomics reveals the effect of lovastatin on steroid-induced n...
Abstract Purpose Lovastatin is an important medicine and it shows a significant effect against glucocorticoid-induced necrosis of the femoral head. This study aimed to... -
IDAAPM: integrated database of ADMET and adverse effects of predictive modeli...
Abstract Background The disposition of a pharmaceutical compound within an organism, i.e. its Absorption, Distribution, Metabolism, Excretion, Toxicity (ADMET) properties and... -
Development of a high-throughput screen to identify small molecule enhancers ...
Abstract Background Duchenne muscular dystrophy (DMD) is caused by loss of sarcolemma connection to the extracellular matrix. Transgenic overexpression of the transmembrane... -
The Ussing chamber system for measuring intestinal permeability in health and...
Abstract Background The relationship between intestinal epithelial integrity and the development of intestinal disease is of increasing interest. A reduction in mucosal... -
Deciphering how LIP2 and POX2 promoters can optimally regulate recombinant pr...
Abstract Background In recent years, the non-conventional model yeast species Yarrowia lipolytica has received much attention because it is a useful cell factory for producing... -
dedup_wf_001--4c8d338775fd0fc8ae9b0c7df2e327de
Team-based learning (TBL) is gradually being integrated into Chinese medical education. This study reports its current application status in Chinese medical schools, as well as... -
Efficient and mild swern oxidation using a new sulfoxide and <i>bis</i>(trich...
A new type of sulfoxide, 4-(2-(2-(methylsulfinyl) ethyl)-4-nitrophenyl)- morpholine (I) was designed and prepared in good yield. Upon the combination of I andbis... -
Resveratrol Binding to Human Complement fragment 5a (<sup>h</sup>C5a) may Mod...
Resveratrol (RSV), the active pharmaceutical ingredient (API) found in several fruits, nuts and marketed nutraceuticals is one of the promiscuous phytoalexin known to promote... -
EnanDIM - a novel family of L-nucleotide-protected TLR9 agonists for cancer i...
Abstract Background Toll-like receptor 9 agonists are potent activators of the immune system. Their clinical potential in immunotherapy against metastatic cancers is being... -
A novel biocatalyst, Enterobacter aerogenes LU2, for efficient production of ...
Abstract Background Succinic acid (SA), a valuable chemical compound with a broad range of industrial uses, has become a subject of global interest in recent years. The... -
Transcriptomic and phosphoproteomic profiling and metabolite analyses reveal ...
Abstract Background Organic acid secretion is a widespread physiological response of plants to alkalinity. However, the characteristics and underlying mechanism of the... -
Assessment of respiratory and systemic toxicity of Benzalkonium chloride foll...
Abstract Background Although biocides at low concentrations have been used to control pests, they can be more harmful than industrial chemicals as humans are directly and... -
Use of a modified GreenScreen tool to conduct a screening-level comparative h...
Abstract Background Increased concern for potential health and environmental impacts of chemicals, including nanomaterials, in consumer products is driving demand for greater... -
Investigating the landscape of US orphan product approvals
Abstract Background The Orphan Drug Act was enacted in 1983 to encourage the development of drugs for rare diseases. Previous research has attempted to examine the impact of the... -
Wnt5a-induced M2 polarization of tumor-associated macrophages via IL-10 promo...
Abstract Background Tumor-associated macrophages (TAMs) in the tumor microenvironment influence tumor initiation, invasion and metastasis. Several studies have shown that Wnt5a... -
A mechanism-based pharmacokinetic model of fenofibrate for explaining increas...
Abstract Background Oral administration of drugs is convenient and shows good compliance but it can be affected by many factors in the gastrointestinal (GI) system. Consumption... -
Adverse weather conditions and fatal motor vehicle crashes in the United Stat...
Abstract Background Motor vehicle crashes are a leading cause of injury mortality. Adverse weather and road conditions have the potential to affect the likelihood of motor... -
High activity CAZyme cassette for improving biomass degradation in thermophiles
Abstract Background Thermophilic microorganisms and their enzymes offer several advantages for industrial application over their mesophilic counterparts. For example, a...
