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Assessment of respiratory and systemic toxicity of Benzalkonium chloride foll...
Abstract Background Although biocides at low concentrations have been used to control pests, they can be more harmful than industrial chemicals as humans are directly and... -
Use of a modified GreenScreen tool to conduct a screening-level comparative h...
Abstract Background Increased concern for potential health and environmental impacts of chemicals, including nanomaterials, in consumer products is driving demand for greater... -
Investigating the landscape of US orphan product approvals
Abstract Background The Orphan Drug Act was enacted in 1983 to encourage the development of drugs for rare diseases. Previous research has attempted to examine the impact of the... -
Wnt5a-induced M2 polarization of tumor-associated macrophages via IL-10 promo...
Abstract Background Tumor-associated macrophages (TAMs) in the tumor microenvironment influence tumor initiation, invasion and metastasis. Several studies have shown that Wnt5a... -
A mechanism-based pharmacokinetic model of fenofibrate for explaining increas...
Abstract Background Oral administration of drugs is convenient and shows good compliance but it can be affected by many factors in the gastrointestinal (GI) system. Consumption... -
Additional file 4: of The prominent alteration in transcriptome and metabolom...
Table S4. The complete list of differentially produced metabolites in control and VB1-treated samples. (XLSX 26 kb) -
Metabolic engineering of indole pyruvic acid biosynthesis in Escherichia coli...
Abstract Background Indole pyruvic acid (IPA) is a versatile platform intermediate and building block for a number of high-value products in the pharmaceutical and food... -
FCMDAP: using miRNA family and cluster information to improve the prediction ...
Abstract Background Biological experiments have confirmed the association between miRNAs and various diseases. However, such experiments are costly and time consuming.... -
Adverse weather conditions and fatal motor vehicle crashes in the United Stat...
Abstract Background Motor vehicle crashes are a leading cause of injury mortality. Adverse weather and road conditions have the potential to affect the likelihood of motor... -
High activity CAZyme cassette for improving biomass degradation in thermophiles
Abstract Background Thermophilic microorganisms and their enzymes offer several advantages for industrial application over their mesophilic counterparts. For example, a... -
MicroRNA-181a as novel liquid biopsy marker of central nervous system involve...
Abstract Background Refractory central nervous system (CNS) involvement is among the major causes of therapy failure in childhood acute leukemia. Applying contemporary... -
Epidermal growth factor prevents APOE4 and amyloid-beta-induced cognitive and...
Abstract Cerebrovascular (CV) dysfunction is emerging as a critical component of Alzheimer’s disease (AD), including altered CV coverage. Angiogenic growth factors (AGFs) are... -
Assessment of tumor suppressor promoter methylation in healthy individuals
Abstract Background The number of tumor suppressor genes for which germline mutations have been linked to cancer risk is steadily increasing. However, while recent reports have... -
Leisure-time, occupational, and commuting physical activity and risk of type ...
Abstract Background Physical activity has been suggested to reduce the risk of type 2 diabetes. However, evidence is limited regarding whether vigorous-intensity activity yields... -
Engineering Saccharomyces cerevisiae with the deletion of endogenous glucosid...
Abstract Background Glycosylation of flavonoids is a promising approach to improve the pharmacokinetic properties and biological activities of flavonoids. Recently, many efforts... -
Metabolic flux analysis for metabolome data validation of naturally xylose-fe...
Abstract Background Efficient xylose fermentation still demands knowledge regarding xylose catabolism. In this study, metabolic flux analysis (MFA) and metabolomics were used to... -
Catalytic and hydrodynamic properties of styrene monooxygenases from Rhodococ...
Abstract Styrene monooxygenases (SMOs) are flavoenzymes catalyzing the epoxidation of styrene into styrene oxide. SMOs are composed of a monooxygenase (StyA) and a reductase... -
Cheminformatics-based enumeration and analysis of large libraries of macrolid...
Abstract We report on the development of a cheminformatics enumeration technology and the analysis of a resulting large dataset of virtual macrolide scaffolds. Although... -
Transcriptome analysis of rubber biosynthesis in guayule (Parthenium argentat...
Abstract Background Natural rubber is currently produced nearly exclusively from latex of the Para rubber tree, Hevea brasiliensis. The desire to reduce the environmental cost... -
Simvastatin and a Plant Galactolipid Protect Animals from Septic Shock by Reg...
Abstract Sepsis remains a major medical issue despite decades of research. Identification of important inflammatory cascades and key molecular mediators are crucial for...
