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Minimizing Mistakes and Embracing Uncertainty
Summary There is increasing concern that most current published research findings are false. The probability that a research claim is true may depend on study power and bias,... -
Informed Consent in the Genomics Era
Informed consent, the process of gathering autonomous authorization for a medical intervention or medical research participation, is a fundamental component of medical practice.... -
Input subsidies to improve smallholder maize productivity in Malawi: toward a...
Emerging from the worst harvest in a decade, the Government of Malawi implemented one of the most ambitious and successful assaults on hunger in the history of the African... -
Principles for Strengthening the Integrity of Clinical Research
‘‘All true universities, whether public or private, are public trusts designed to advance knowledge by safeguarding the free inquiry of impartial teachers and scholars. Their... -
Evolution and Translation of Research Findings: From Bench to Where
The credibility and replication of research findings evolve over time, as data accumulate. However, translation of postulated research promises to real-life biomedical... -
The Shifting Boundaries of Sustainability Science: Are We Doomed Yet?
Global consumption rates of vital resources suggest that we have surpassed the capacity of the Earth to sustain current levels, much less future trajectories of growth in human... -
Preprints: An underutilized mechanism to accelerate outbreak science.
Background In December 2019, a pneumonia caused by a novel coronavirus (SARS-CoV-2) emerged in Wuhan, China and has rapidly spread around the world since then. Aim This study... -
Genes, cells, and biobanks: Yes, there’s still a consent problem
From a research perspective, the interest in biobanking continues to intensify. Governments and industry have invested heavily in biobanks, as exemplified by initiatives like... -
Where there is no health research: what can be done to fill the global gaps i...
Efforts to strengthen capacity in health research have, so far, concentrated on countries where there is existing capacity rather than those where it is almost completely... -
Closing the Gaps: From Science to Action in Maternal, Newborn, and Child Heal...
This paper focuses upon improving implementation in maternal neonatal and child health (MNCH) in Africa. It touches on: implementation science engagement of voices from those on... -
Fertilizing Nature: A Tragedy of Excess in the Commons
Why has nitrogen fertilizer use declined in some countries while increasing in others, despite significant environmental harm? Proper crop management strategies offer... -
Medicine goes to school: teachers as sickness brokers for ADHD.
Christine Phillips explores the roles of teachers as brokers for ADHD and its treatment, and the strategies used by the pharmaceutical industry to frame educators' responses to... -
A Comparison of DSM-IV and DSM-5 Panel Members' Financial Associations with I...
Lisa Cosgrove and Sheldon Krimsky examine the new competing interest disclosure policy of the American Psychiatric Association (APA) and report that DSM panel members still have... -
A New Trade Framework for Global Healthcare R&D
The AIDS crisis has brought to public notice what has always been generally true—that the existing business model for drug development leads to high prices and unequal access.... -
Protecting Migration Corridors: Challenges and Optimism for Mongolian Saiga
Animal migration surely ranks as one of nature's most visible and widespread phenomena. Every minute of every day, somewhere, some place, animals are on the move. The migrants... -
Research Conducted Using Data Obtained through Online Communities: Ethical Im...
An increasing number of public and commercial initiatives invite individuals to participate in scientific research via the internet (Table 1). People are asked to provide... -
Why Most Clinical Research Is Not Useful
ABSTRACT Some diseases can be cured by medical interventions, others not. When not, are there other approaches to control or cure? One possibility is to try to publish a disease... -
Selection in Reported Epidemiological Risks: An Empirical Assessment
Summary The current system of publication in biomedical research provides a distorted view of the reality of scientific data that are generated in the laboratory and clinic.... -
Challenges in addressing plagiarism in education
In a new Essay as part of the Research Integrity Series, Tracey Bretag discusses the complex problem of plagiarism within the education system. Please see later in the article... -
Evidence-Based Priority Setting for Health Care and Research: Tools to Suppor...
CITATION: Rudan, I., et al. 2010. Evidence-based priority setting for health care and research : tools to support policy in maternal, neonatal, and child health in Africa. PLoS...
