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Comparative analyses of the in vivo induction and transmission of α-synuclein...
Abstract α-synuclein (αS) is the major component of several types of brain pathological inclusions that define neurodegenerative diseases termed synucleinopathies. Central... -
Dimethyl fumarate attenuates reactive microglia and long-term memory deficits...
Abstract Background Systemic inflammation is associated with increased cognitive decline and risk for Alzheimer’s disease. Microglia (MG) activated during systemic inflammation... -
Avelumab in patients with previously treated metastatic melanoma: phase 1b re...
Abstract Background We report phase 1b data from patients enrolled in the JAVELIN Solid Tumor clinical trial (NCT01772004) with unresectable stage IIIC or IV melanoma that had... -
SEA-MAKE score as a tool for predicting major adverse kidney events in critic...
Abstract Background Acute kidney injury (AKI) is a common problem in critically ill patients and associated with high rates of morbidity and mortality. Recently, Major Adverse... -
Effects of cyclosporine A pretreatment of deceased organ donors on kidney gra...
Abstract Background Renal transplantation represents the treatment of choice of end-stage kidney disease. Delayed graft function (DGF) remains the most frequent complication... -
Sucroferric oxyhydroxide decreases serum phosphorus level and fibroblast grow...
Abstract Objective Sucroferric oxyhydroxide, a novel iron-based phosphate-binder, has been shown to have beneficial effects in lowering serum phosphorus levels and improving... -
Biodegradable polymer drug-eluting stents versus second-generation drug-eluti...
Abstract Background To improve outcomes in patients with diabetes mellitus (DM) undergoing percutaneous coronary intervention remain an unmet clinical need. The study aimed to... -
Multiphoton in vivo imaging with a femtosecond semiconductor disk laser
We use an ultrafast diode-pumped semiconductor disk laser (SDL) to demonstrate several applications in multiphoton microscopy. The ultrafast SDL is based on an optically pumped... -
Use of thiazide diuretics for the prevention of recurrent kidney calculi: a s...
Abstract Background Thiazide diuretics reduce the risk of recurrent kidney calculi in patients with kidney calculi or hypercalciuria. However, whether thiazide diuretics can... -
Chronic alcohol-induced neuroinflammation involves CCR2/5-dependent periphera...
Abstract Background Chronic alcohol consumption is associated with neuroinflammation, neuronal damage, and behavioral alterations including addiction. Alcohol-induced... -
Life and expectations post-kidney transplant: a qualitative analysis of patie...
Abstract Background The effect of a kidney transplant on a recipient extends beyond the restoration of kidney function. However, there is limited qualitative analysis of... -
Association between hydroxocobalamin administration and acute kidney injury a...
Abstract Background The use of hydroxocobalamin has long been advocated for treating suspected cyanide poisoning after smoke inhalation. Intravenous hydroxocobalamin has however... -
MORG1+/− mice are protected from histological renal damage and inflammation i...
Abstract Background The MAPK-organizer 1 (MORG1) play a scaffold function in the MAPK and/or the PHD3 signalling paths. Recently, we reported that MORG1+/− mice are protected... -
A prospective, multi-centre, observational study to examine kidney disease pr...
Abstract Background The objective of this article is to describe the organisation of an international, clinical registry, the Chronic Kidney Disease Observational Database... -
Asthmatic bronchial epithelial cells promote the establishment of a Hyalurona...
Abstract Background Airway inflammation is a hallmark of asthma. Alterations in extracellular matrix (ECM) hyaluronan (HA) content have been shown to modulate the recruitment... -
Inhaled nitric oxide for neonates with persistent pulmonary hypertension of t...
Abstract Background Substantial numbers of neonates with hypoxic respiratory failure (HRF) do not immediately respond to inhaled nitric oxide (iNO) and are often labeled as... -
Minoxidil versus placebo in the treatment of arterial wall hypertrophy in chi...
Abstract Background Insufficient elastin synthesis leads to vascular complications and arterial hypertension in children with Williams-Beuren syndrome. Restoring sufficient... -
Long-term safety and effectiveness of a continuous erythropoietin receptor ac...
Abstract Background This observational study investigated the safety and effectiveness of continuous erythropoietin receptor activator in patients with renal anemia in Japan.... -
Comparative effectiveness and safety of tranexamic acid plus diluted epinephr...
Abstract Background The standard protocol to achieve haemostasis during total hip arthroplasty (THA) is uncertain. Tranexamic acid plus diluted epinephrine (DEP) and tranexamic... -
Lower blood pressure and risk of cisplatin nephrotoxicity: a retrospective co...
Abstract Background The pathophysiological mechanisms of cisplatin nephrotoxicity include the reduction of renal blood flow, as well as tubular epithelial cell toxicity. The...
