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Activation of the EIF2AK4-EIF2A/eIF2α-ATF4 pathway triggers autophagy respons...
The intestinal mucosa of Crohn disease (CD) patients is abnormally colonized by adherent-invasive E. coli (AIEC). Upon AIEC infection, autophagy is induced in host cells to... -
Activin and TGFβ use diverging mitogenic signaling in advanced colon cancer
Abstract Background Understanding cell signaling pathways that contribute to metastatic colon cancer is critical to risk stratification in the era of personalized therapeutics.... -
Transcriptional reprogramming strategies and miRNA-mediated regulation networ...
Abstract Background Taxus cells are a potential sustainable and environment-friendly source of taxol, but they have low survival ratios and slow grow rates. Despite these... -
Development of a new promoter to avoid the silencing of genes in the producti...
Abstract Background The production of recombinant proteins in mammalian cell lines is one of the most important areas in biopharmaceutical industry. Viral transcriptional... -
RNA polymerase II depletion promotes transcription of alternative mRNA species
Abstract Background Cells respond to numerous internal and external stresses, such as heat, cold, oxidative stress, DNA damage, and osmotic pressure changes. In most cases, the... -
WD-repeat protein WDR13 is a novel transcriptional regulator of c-Jun and mod...
Abstract Background WDR13 is a member of the WD repeat protein family and is expressed in several tissues of human and mice. Previous studies in our laboratory showed that the... -
Regulation of platelet-activating factor-mediated interleukin-6 promoter acti...
Abstract Background An underlying state of inflammation is thought to be an important cause of cardiovascular disease. Among cells involved in the early steps of... -
Cytosolic sulfotransferase 1A1 regulates HIV-1 minus-strand DNA elongation in...
Abstract Background The cellular sulfonation pathway modulates key steps of virus replication. This pathway comprises two main families of sulfonate-conjugating enzymes: Golgi... -
DNA-binding sequence specificity of DUX4
Abstract Background Misexpression of the double homeodomain transcription factor DUX4 results in facioscapulohumeral muscular dystrophy (FSHD). A DNA-binding consensus with two... -
A bacterial negative transcription regulator binding on an inverted repeat in...
Abstract Background Microbial secondary metabolism is regulated by a complex and mostly-unknown network of global and pathway-specific regulators. A dozen biosynthetic gene... -
Nuclear localization of Newcastle disease virus matrix protein promotes virus...
Abstract Nuclear localization of paramyxovirus proteins is crucial for virus life cycle, including the regulation of viral replication and the evasion of host immunity. We... -
Modulation of the Nrf2 signalling pathway in Hct116 colon carcinoma cells by ...
Context: Baicalein is a major compound in extracts derived from Scutellaria baicalensis Georgi (Lamiaceae) which are used in the Traditional Chinese Medicine for the treatment... -
Jasmonate-mediated defence responses, unlike salicylate-mediated responses, a...
Abstract Background Bois noir is an important disease of grapevine (Vitis vinifera L.), caused by phytoplasmas. An interesting, yet elusive aspect of the bois noir disease is â... -
Tissue-specific transcriptomes of Anisakis simplex (sensu stricto) and Anisak...
Abstract Background Larval stages of the sibling species of parasitic nematodes Anisakis simplex (sensu stricto) (s.s.) (AS) and Anisakis pegreffii (AP) are responsible for a... -
Activity profile of defence-related enzymes in rice genotypes (<i>Oryza sativ...
The control and infected leaf samples of blast resistant and susceptible rice genotypes were evaluated for activities of defence-related enzymes viz., total phenol content,... -
G45R mutation in the nonstructural protein 1 of A/Puerto Rico/8/1934 (H1N1) e...
Abstract Background The nonstructural protein 1 (NS1) of influenza A viruses can act as a viral replication enhancer by antagonizing type I interferon (IFN) induction and... -
Amino acid residues critical for DNA binding and inducer recognition in CbnR,...
CbnR, a LysR-type transcriptional regulator from Cupriavidus necator NH9, activates the transcription of chlorocatechol-degradative enzymes. To activate the transcription, CbnR... -
PKN2 in colon cancer cells inhibits M2 phenotype polarization of tumor-associ...
Abstract Background Protein kinase N2 (PKN2) is a PKC-related serine/threonine-protein kinase. PKN2 is required for tumor cell migration, invasion and apoptosis. However, the... -
Pasteurella multocida toxin- induced osteoclastogenesis requires mTOR activation
Abstract Background Pasteurella multocida toxin (PMT) is a potent inducer of osteoclast formation. Pigs suffering from an infection with toxigenic Pasteurella multocida strains... -
Short versus long double-stranded RNA activation of a post-transcriptional ge...
RNA interference (RNAi) utilizes a conserved cellular autoimmune defense mechanism involving the internalization of dsRNA into cells and the activation of a set of RNAi related...
