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Omalizumab in patients with severe asthma and persistent sputum eosinophilia
Abstract Omalizumab, a recombinant humanized monoclonal antibody targeting the IgE molecule, is the first biologic approved for moderate-to-severe allergic asthmatics, who... -
ISSEC: inferring contacts among protein secondary structure elements using de...
Abstract Background The formation of contacts among protein secondary structure elements (SSEs) is an important step in protein folding as it determines topology of protein... -
Comparing structural fingerprints using a literature-based similarity benchmark
Abstract Background The concept of molecular similarity is one of the central ideas in cheminformatics, despite the fact that it is ill-defined and rather difficult to assess... -
Combining structural and bioactivity-based fingerprints improves prediction p...
Abstract This study aims at improving upon existing activity predictions methods by augmenting chemical structure fingerprints with bio-activity based fingerprints derived from... -
Engineering yeast artificial core promoter with designated base motifs
Abstract Background Synthetic biology requires toolbox of promoters to finely tune gene expression levels for building up efficient cell factories. Yeast promoters owned... -
Analysis of SARS-CoV-2 RNA-dependent RNA polymerase as a potential therapeuti...
Abstract Background The Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) outbreak originating in Wuhan, China, has raised global health concerns and the... -
A principal components method constrained by elementary flux modes: analysis ...
Abstract Background Non-negative linear combinations of elementary flux modes (EMs) describe all feasible reaction flux distributions for a given metabolic network under the... -
Can human experts predict solubility better than computers?
Abstract In this study, we design and carry out a survey, asking human experts to predict the aqueous solubility of druglike organic compounds. We investigate whether these... -
Asymptomatic Clostridium difficile colonization: epidemiology and clinical im...
Abstract Background The epidemiology of Clostridium difficile infection (CDI) has changed over the past decades with the emergence of highly virulent strains. The role of... -
Inherent bacterial DNA contamination of extraction and sequencing reagents ma...
Abstract Background The advent and use of highly sensitive molecular biology techniques to explore the microbiota and microbiome in environmental and tissue samples have... -
FCMDAP: using miRNA family and cluster information to improve the prediction ...
Abstract Background Biological experiments have confirmed the association between miRNAs and various diseases. However, such experiments are costly and time consuming.... -
GAPPadder: a sensitive approach for closing gaps on draft genomes with short ...
Abstract Background Closing gaps in draft genomes is an important post processing step in genome assembly. It leads to more complete genomes, which benefits downstream genome... -
Methods and indicators for measuring patterns of human exposure to malaria ve...
Abstract Background Effective targeting and evaluation of interventions that protect against adult malaria vectors requires an understanding of how gaps in personal protection... -
Up-regulated NRIP2 in colorectal cancer initiating cells modulates the Wnt pa...
Abstract Background Colorectal cancer remains one of the most common malignant tumors worldwide. Colorectal cancer initiating cells (CCICs) are a small subpopulation responsible... -
Antimicrobial peptide similarity and classification through rough set theory ...
Abstract Background Antimicrobial peptides attract considerable interest as novel agents to combat infections. Their long-time potency across bacteria, viruses and fungi as part... -
Predicting clinically promising therapeutic hypotheses using tensor factoriza...
Abstract Background Determining which target to pursue is a challenging and error-prone first step in developing a therapeutic treatment for a disease, where missteps are... -
Structural and mechanistic analysis of engineered trichodiene synthase enzyme...
Trichoderma spp. are well-known bioagents for the plant growth promotion and pathogen suppression. The beneficial activities of the fungus Trichoderma spp. are attributed to... -
"gnparser": a powerful parser for scientific names based on Parsing Expressio...
Abstract Background Scientific names in biology act as universal links. They allow us to cross-reference information about organisms globally. However variations in spelling of... -
Applications of Choline Amino Acid Ionic Liquid in Extraction and Separation ...
Choline leucine ionic liquid solution was chosen to simultaneously extract flavonoids and pectin from ponkan peels, which were subsequently isolated by the corresponding... -
Schmutzi: estimation of contamination and endogenous mitochondrial consensus ...
Abstract Ancient DNA is typically highly degraded with appreciable cytosine deamination, and contamination with present-day DNA often complicates the identification of...
