-
Aberrant activation of NF-κB signaling in mammary epithelium leads to abnorma...
Abstract Background Approximately 1 in 5 women diagnosed with breast cancer are considered to have in situ disease, most often termed ductal carcinoma in situ (DCIS). Though... -
Continuous hemofiltration improves the prognosis of bacterial sepsis complica...
Abstract Background Liver dysfunction is an independent risk factor for poor prognosis of patients with sepsis. The aim of this study is to evaluate the effects of continuous... -
Lipopolysaccharide-induced neuroinflammation induces presynaptic disruption t...
Abstract Background Systemic inflammation has been linked to synapse loss and cognitive decline in human patients and animal models. A role for microglial release of... -
Microbiota from alginate oligosaccharide-dosed mice successfully mitigated sm...
Abstract Background The increasing incidence of cancer and intestinal mucositis induced by chemotherapeutics are causing worldwide concern. Many approaches such as fecal... -
Light-induced gene expression with photocaged IPTG for induction profiling in...
Abstract Background Inducible expression systems are frequently used for the production of heterologous proteins. Achieving maximum product concentrations requires induction... -
The Ussing chamber system for measuring intestinal permeability in health and...
Abstract Background The relationship between intestinal epithelial integrity and the development of intestinal disease is of increasing interest. A reduction in mucosal... -
Gastric Parietal Cell and Intestinal Goblet Cell Secretion: a Novel Cell-Medi...
Abstract Up to date, the way in which metal nanoparticles are cleared in vivo has yet to be elucidated well. Herein, we report a novel intestinal goblet cell-mediated in vivo... -
Epidural adipose tissue-derived mesenchymal stem cell activation induced by l...
Abstract Background Spinal metastasis is a major challenge in patients with advanced lung cancer, but the mechanisms in the organotropism of metastasis are still unclear.... -
Transcriptome analysis reveals regional and temporal differences in mucosal i...
Abstract Background Postnatal development of the mammalian mucosal immune system is crucial for responding to the rapid colonization by commensal bacteria and possible exposure... -
Endothelial bioreactor system ameliorates multiple organ dysfunction in septi...
Abstract Background The endothelium is a potentially valuable target for sepsis therapy. We have previously studied an extracorporeal endothelial cell therapy system, called the... -
Skin autofluorescence is associated with inappropriate left ventricular mass ...
Abstract Background Enhanced advanced glycation end products deposition within myocardial tissue may cause diastolic dysfunction. However, whether this is related to left... -
Fiber-based polarization-sensitive OCT for birefringence imaging of the anter...
We demonstrate a prototype system of polarization-sensitive optical coherence tomography (PS-OCT) designed for clinical studies of the anterior eye segment imaging. The system... -
Diagnostic ability of macular ganglion cell asymmetry in Preperimetric Glaucoma
Abstract Background To evaluate the diagnostic ability of macular ganglion cell asymmetry to diagnose preperimetric glaucoma (PPG), using Cirrus spectral domain optical... -
Blood transfusion improves renal oxygenation and renal function in sepsis-ind...
Abstract Background The effects of blood transfusion on renal microcirculation during sepsis are unknown. This study aimed to investigate the effect of blood transfusion on... -
Cerebral endothelial dysfunction in reversible cerebral vasoconstriction synd...
Abstract Background The aim of this study is to investigate cerebral endothelial dysfunction in patients with reversible cerebral vasoconstriction syndrome (RCVS). Methods We... -
Gelatin-based perfusable, endothelial carotid artery model for the study of a...
Abstract Background Carotid artery geometry is important for recapitulating a pathophysiological microenvironment to study wall shear stress (WSS)-induced endothelial... -
Improved co-registration of ex-vivo and in-vivo cardiovascular magnetic reson...
Abstract Background Ex-vivo cardiovascular magnetic resonance (CMR) imaging has played an important role in the validation of in-vivo CMR characterization of pathological... -
Risk factors for iliopsoas impingement after total hip arthroplasty using a c...
Abstract Background The relationship between collar design of a femoral component and iliopsoas impingement (IPI) after total hip arthroplasty (THA) is still underrecognized.... -
Deletion of Nlrp3 protects from inflammation-induced skeletal muscle atrophy
Abstract Background Critically ill patients develop atrophic muscle failure, which increases morbidity and mortality. Interleukin-1β (IL-1β) is activated early in sepsis.... -
Umbilical cord/placenta-derived mesenchymal stem cells inhibit fibrogenic act...
Abstract Background The lack of anti-fibrotic agents targeting intestinal fibrosis is a large unmet need in inflammatory bowel diseases, including Crohn’s disease and ulcerative...
