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Genetic tool for fate mapping of Oct4 (Pou5f1)-expressing cells and their pro...
Abstract Background Methods based on site-specific recombinases are widely used in studying gene activities in vivo and in vitro. In these studies, constitutively active or... -
A novel transcription factor specifically regulates GH11 xylanase genes in Tr...
Abstract Background The filamentous fungus Trichoderma reesei is widely utilized in industry for cellulase production, but its xylanase activity must be improved to enhance the... -
Identification of a putative methyltransferase gene of Babesia bigemina as a ...
Abstract Background Bovine babesiosis is caused by apicomplexan pathogens of the genus Babesia such as B. bigemina and B. bovis. These tick-borne pathogens have a complex... -
Chromosomal integration vectors allowing flexible expression of foreign genes...
Abstract Background Campylobacter jejuni is a major cause of human gastroenteritis yet there is limited knowledge of how disease is caused. Molecular genetic approaches are... -
Transcriptome analysis reveals regional and temporal differences in mucosal i...
Abstract Background Postnatal development of the mammalian mucosal immune system is crucial for responding to the rapid colonization by commensal bacteria and possible exposure... -
High shear stress suppresses proliferation and migration but promotes apoptos...
Abstract Background Early neointimal hyperplasia of vein graft may be ameliorated via enhancing intravenous surface shear stress. Cellular processes including proliferation,... -
Overexpression of MALT1-A20-NF-κB in adult B-cell acute lymphoblastic leukemia
Abstract Background A20 is a dual inhibitor of NF-κB activation and apoptosis in the tumor necrosis factor receptor 1 signaling pathway, and both are related to tumorigenesis.... -
Improved co-registration of ex-vivo and in-vivo cardiovascular magnetic reson...
Abstract Background Ex-vivo cardiovascular magnetic resonance (CMR) imaging has played an important role in the validation of in-vivo CMR characterization of pathological... -
An advanced bioinformatics approach for analyzing RNA-seq data reveals sigma ...
Abstract Background Alternative σ factors are important transcriptional regulators in bacteria. While σB has been shown to control a large regulon and play important roles in... -
Cancer-derived exosomal TRIM59 regulates macrophage NLRP3 inflammasome activa...
Abstract Background Exosomes are emerging as important mediators of the cross-talk between tumor cells and the microenvironment. The communication between tumor-derived exosomes... -
NFкB is a critical transcriptional regulator of atypical cadherin FAT1 in glioma
Abstract Background Overexpression of FAT1 gene and its oncogenic effects have been reported in several cancers. Previously, we have documented upregulation of FAT1 gene in... -
Deletion of Nlrp3 protects from inflammation-induced skeletal muscle atrophy
Abstract Background Critically ill patients develop atrophic muscle failure, which increases morbidity and mortality. Interleukin-1β (IL-1β) is activated early in sepsis.... -
Umbilical cord/placenta-derived mesenchymal stem cells inhibit fibrogenic act...
Abstract Background The lack of anti-fibrotic agents targeting intestinal fibrosis is a large unmet need in inflammatory bowel diseases, including Crohn’s disease and ulcerative... -
Cellulase hyper-production by Trichoderma reesei mutant SEU-7 on lactose
Abstract Background The induction of cellulase production by insoluble carbon source cellulose was a common and efficient strategy, but has some drawbacks, such as difficult... -
The acid-sensing ion channel, ASIC2, promotes invasion and metastasis of colo...
Abstract Background The tumor acidic microenvironment, a common biochemical event in solid tumors, offers evolutional advantage for tumors cells and even enhances their... -
Myeloid C/EBPβ deficiency reshapes microglial gene expression and is protecti...
Abstract Background CCAAT/enhancer binding protein β (C/EBPβ) is a transcription factor that regulates the expression of important pro-inflammatory genes in microglia. Mice... -
Developmental basis for intestinal barrier against the toxicity of graphene o...
Abstract Background Intestinal barrier is crucial for animals against translocation of engineered nanomaterials (ENMs) into secondary targeted organs. However, the molecular...
