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Retrospective analysis in oculocutaneous albinism patients for the 2.7 kb del...
Abstract Background Oculocutaneous albinism (OCA) is an autosomal recessive disorder. A significant portion of OCA patients has been found with a single pathogenic variant... -
Genome-wide characterization of human L1 antisense promoter-driven transcripts
Abstract Background Long INterspersed Element-1 (LINE-1 or L1) is the only autonomously active, transposable element in the human genome. L1 sequences comprise approximately 17... -
Pancreatic cancer-initiating cell exosome message transfer into noncancer-ini...
Abstract Background Cancer-initiating cell (CIC) exosomes (CIC-TEX) are suggested reprogramming Non-CIC. Mode of message transfer and engagement of CIC-markers being disputed,... -
Hemodynamic impacts of flow diverter devices on the ophthalmic artery
Abstract Background Flow diverter devices are increasingly used for endovascular treatment of internal carotid artery aneurysms. Treatment of ophthalmic segment aneurysms with... -
Comprehensive analysis of LDHAP5 pseudogene expression and potential pathogen...
Abstract Background We aimed to identify differentially expressed pseudogenes and explore their potential functions in four types of common gynecological malignancies (e.g.,... -
Characterization of novel Bovine Leukemia Virus (BLV) antisense transcripts b...
Abstract Background Bovine Leukemia Virus (BLV) is a deltaretrovirus closely related to the Human T cell leukemia virus-1 (HTLV-1). Cattle are the natural host of BLV where it... -
A novel ultra-sensitive method for the detection of FGFR3 mutations in urine ...
Abstract Background We have recently developed a highly accurate urine-based test, named Urodiag®, associating FGFR3 mutation and DNA methylation assays for recurrence... -
Identification and validation of a Schistosoma japonicum U6 promoter
Abstract Background RNA polymerase III promoters have been widely used to express short hairpin-RNA (shRNA), microRNA (miRNA), and small guide RNA (sgRNA) in gene functional... -
m6A mRNA methylation initiated by METTL3 directly promotes YAP translation an...
Abstract Background METTL3 is an RNA methyltransferase that mediates m6A modification and is implicated in mRNA biogenesis, decay, and translation. However, the biomechanism... -
The chicken erythrocyte epigenome
Abstract Background Transcriptional regulation is impacted by multiple layers of genome organization. A general feature of transcriptionally active chromatin is sensitivity to... -
Gene expression profiling analysis of CRTC1-MAML2 fusion oncogene-induced tra...
Abstract Background Mucoepidermoid carcinoma (MEC) arises from multiple organs and accounts for the most common types of salivary gland malignancies. Currently, patients with... -
Bidirectional promoters exhibit characteristic chromatin modification signatu...
Abstract Background In contrast to unidirectional promoters wherein antisense transcription results in short transcripts which are rapidly degraded, bidirectional promoters... -
NPM1 alternative transcripts are upregulated in acute myeloid and lymphoblast...
Abstract Background Expression of the NPM1 gene, encoding nucleophosmin, is upregulated in cancers. Although more than ten NPM1 transcripts are known, the reports were usually... -
Transcriptional activation of USP16 gene expression by NFκB signaling
Abstract Ubiquitin Specific Peptidase 16 (USP16) has been reported to contribute to somatic stem-cell defects in Down syndrome. However, how this gene being regulated is largely... -
Identification and application of a growth-regulated promoter for improving l...
Abstract Background Promoters are commonly used to regulate the expression of specific target genes or operons. Although a series of promoters have been developed in... -
Karyotyping of circulating tumor cells for predicting chemotherapeutic sensit...
Abstract Background Aneuploidy of chromosome 8 in circulating tumor cells (CTCs) has been reported correlates with therapeutic efficacy and prognosis in patients with advanced... -
MicroRNA-23a regulates epithelial-to-mesenchymal transition in endometrial en...
Abstract Background To investigate the role of total cellular microRNA (miRNA) in regulating epithelial-to-mesenchymal transition (EMT) during human endometrial endometrioid... -
Human transposons are an abundant supply of transcription factor binding site...
Abstract Background Transposable elements (TE) are commonly regarded as â junk DNAâ with no apparent regulatory roles in the human genome. However, a growing body of evidence... -
Functional characterization of BmOVOs in silkworm, Bombyx mori
Abstract Background In our previous study, we identified four isoforms of the Bmovo gene, Bmovo-1, Bmovo-2, Bmovo-3 and Bmovo-4 from the silkworm ovary and verified that ovarian... -
First evidence of a new simian adenovirus clustering with Human mastadenoviru...
Abstract Background Adenoviruses play an important role as human pathogens, though most infections are believed to be asymptomatic. The over 100 human adenovirus types are...
