-
Pancreatic cancer-initiating cell exosome message transfer into noncancer-ini...
Abstract Background Cancer-initiating cell (CIC) exosomes (CIC-TEX) are suggested reprogramming Non-CIC. Mode of message transfer and engagement of CIC-markers being disputed,... -
Comprehensive analysis of LDHAP5 pseudogene expression and potential pathogen...
Abstract Background We aimed to identify differentially expressed pseudogenes and explore their potential functions in four types of common gynecological malignancies (e.g.,... -
Characterization of novel Bovine Leukemia Virus (BLV) antisense transcripts b...
Abstract Background Bovine Leukemia Virus (BLV) is a deltaretrovirus closely related to the Human T cell leukemia virus-1 (HTLV-1). Cattle are the natural host of BLV where it... -
Identification and validation of a Schistosoma japonicum U6 promoter
Abstract Background RNA polymerase III promoters have been widely used to express short hairpin-RNA (shRNA), microRNA (miRNA), and small guide RNA (sgRNA) in gene functional... -
m6A mRNA methylation initiated by METTL3 directly promotes YAP translation an...
Abstract Background METTL3 is an RNA methyltransferase that mediates m6A modification and is implicated in mRNA biogenesis, decay, and translation. However, the biomechanism... -
The chicken erythrocyte epigenome
Abstract Background Transcriptional regulation is impacted by multiple layers of genome organization. A general feature of transcriptionally active chromatin is sensitivity to... -
Transcriptional activation of USP16 gene expression by NFκB signaling
Abstract Ubiquitin Specific Peptidase 16 (USP16) has been reported to contribute to somatic stem-cell defects in Down syndrome. However, how this gene being regulated is largely... -
Identification and application of a growth-regulated promoter for improving l...
Abstract Background Promoters are commonly used to regulate the expression of specific target genes or operons. Although a series of promoters have been developed in... -
Functional characterization of BmOVOs in silkworm, Bombyx mori
Abstract Background In our previous study, we identified four isoforms of the Bmovo gene, Bmovo-1, Bmovo-2, Bmovo-3 and Bmovo-4 from the silkworm ovary and verified that ovarian... -
ΗΙF1α, EGR1 and SP1 co-regulate the erythropoietin receptor expression under ...
Abstract Background Overexpression of erythropoietin (EPO) and EPO receptor (EPO-R) is associated with poor prognosis in non-small-cell lung carcinoma (NSCLC). Hypoxia, a potent... -
Genome-wide RNA pol II initiation and pausing in neural progenitors of the rat
Abstract Background Global RNA sequencing technologies have revealed widespread RNA polymerase II (Pol II) transcription outside of gene promoters. Small 5â ˛-capped RNA... -
Identification of Matrix Metalloproteinase-12 as a Candidate Molecule for Pre...
Abstract Obesity is strongly associated with metabolic syndrome, a combination of risk factors that predisposes to development of the cardiometabolic diseases: atherosclerotic... -
"Hit-and-Run" transcription: de novo transcription initiated by a transient b...
Abstract Background Dynamic transcriptional regulation is critical for an organism’s response to environmental signals and yet remains elusive to capture. Such transcriptional... -
Promoter expression of HERV-K (HML-2) provirus-derived sequences is related t...
Abstract Background Increased transcription of the human endogenous retrovirus group HERV-K (HML-2) is often seen during disease. Although the mechanism of its tissue-specific... -
FtMYB8 from Tartary buckwheat inhibits both anthocyanin/Proanthocyanidin accu...
Abstract Background Because flavonoids and trichomes play crucial roles in plant defence, their formation requires fine transcriptional control by multiple transcription factor... -
A kinetic metabolic study of lipid production in Chlorella protothecoides und...
Abstract Background Microalgae have been proposed as potential platform to produce lipid-derived products, such as biofuels. Knowledge on the intracellular carbon flow... -
The active role of the transcription factor Sp1 in NFATc2-mediated gene regul...
Abstract Background Adenocarcinoma of the pancreas is one of the most aggressive tumor diseases affecting the human body. The oncogenic potential of pancreatic cancer is mainly...
