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Pathological complete response due to a prolonged time interval between preop...
Abstract Background Preoperative chemoradiotherapy is the recommended standard of care for patients with local advanced rectal cancer. However, it remains unclear, whether a... -
Periostin involved in the activated hepatic stellate cells-induced progressio...
Abstract Background Incomplete thermal ablation may induce invasiveness of hepatocellular carcinoma (HCC). Here, we investigated whether activated hepatic stellate cells (HSCs)... -
Prenatal alcohol exposure and infant gross motor development: a prospective c...
Abstract Background Maternal alcohol consumption in pregnancy may have adverse effects on child gross motor (GM) development. There have been few human studies on this topic,... -
Comparative cardiopulmonary toxicity of exhausts from soy-based biofuels and ...
Increased use of renewable energy sources raise concerns about health effects of new emissions. We analyzed relative cardiopulmonary health effects of exhausts from (1) 100% soy... -
Micronutrient-rich dietary intake is associated with a reduction in the effec...
Abstract Background Informal recycling of electronic waste (e-waste) releases particulate matter (PM) into the ambient air. Human exposure to PM has been reported to induce... -
Topical application of nebulized human IgG, IgA and IgAM in the lungs of rats...
Abstract Background Recurrent and persistent infections are known to affect airways of patients with Primary Immunodeficiency despite appropriate replacement immunoglobulin... -
Use of 55 PET radiotracers under approval of a Radioactive Drug Research Comm...
Abstract Background In the US, EU and elsewhere, basic clinical research studies with positron emission tomography (PET) radiotracers that are generally recognized as safe and... -
Internists‘ career choice towards primary care: a cross-sectional survey
Abstract Background Swiss primary care (PC) is facing workforce shortage. Up to 2011 this workforce was supplied by two board certifications: general medicine and internal... -
Urinary tract infections in pregnancy in a rural population of Bangladesh: po...
Abstract Background Urinary tract infection (UTI) in pregnancy, including asymptomatic bacteriuria, is associated with maternal morbidity and adverse pregnancy outcomes,... -
Epigenetic and non-epigenetic mode of SIRT1 action during oocyte meiosis prog...
Abstract Background SIRT1 histone deacetylase acts on many epigenetic and non-epigenetic targets. It is thought that SIRT1 is involved in oocyte maturation; therefore, the... -
Pharmacovigilance of suspected or confirmed therapeutic ineffectiveness of ar...
Abstract Background Therapeutic ineffectiveness of artemisinin-based combination therapy (ACT) increases the risk of malaria-related morbidity and mortality, and raises... -
Inequities in maternal health services utilization in Ethiopia 2000–2016: mag...
Abstract Background Inequities in maternal health services utilization constitute a major challenge in maternal mortality reduction in Ethiopia. We sought to assess magnitude,... -
Meta-analysis of human gene expression in response to Mycobacterium tuberculo...
Abstract Background With the global emergence of multi-drug resistant strains of Mycobacterium tuberculosis, new strategies to treat tuberculosis are urgently needed such as... -
Use of antimicrobial resistance information and prescribing guidance for mana...
Abstract Background There is a marked variation in both antibiotic prescribing practice and urine sampling rates for diagnostic microbiology across general practices in England.... -
Point-of-care ultrasound curriculum for internal medicine residents: what do ...
Abstract Background Point-of-care Ultrasound is a relative new diagnostic tool for internists. Since 2019, it is a mandatory skill for internal medicine residents in the... -
[18F]tetrafluoroborate as a PET tracer for the sodium/iodide symporter: the i...
Abstract Background [18F]BF4 −, the first 18F-labelled PET imaging agent for the sodium/iodide symporter (NIS), was produced by isotopic exchange yielding a product with limited... -
SiO2 and TiO2 nanoparticles synergistically trigger macrophage inflammatory r...
Abstract Silicon dioxide (SiO2) nanoparticles (NPs) and titanium dioxide (TiO2) NPs are the most widely used inorganic nanomaterials. Although the individual toxicities of SiO2... -
Evaluation of a simple tool to assess the results of Ponseti treatment for us...
Abstract Background We aimed to develop and evaluate a tool for clubfoot therapists in low resource settings to assess the results of Ponseti treatment of congenital talipes... -
The assessment of new drugs for asthma and COPD: a Delphi study examining the...
Abstract Background Asthma and chronic obstructive pulmonary disease (COPD) are disorders of the lungs characterized by airflow obstruction, inflammation and tissue remodeling.... -
Neutrophil extracellular traps induce aggregation of washed human platelets i...
Abstract Background The release of neutrophil extracellular traps (NETs), a mesh of DNA, histones and neutrophil proteases from neutrophils, was first demonstrated as a host...
