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Differences in reported sepsis incidence according to study design: a literat...
Abstract Background Sepsis and severe sepsis are common conditions in hospital settings, and are associated with high rates of morbidity and mortality, but reported incidences... -
Validation of the Moroccan arabic version of the low anterior resection syndr...
Abstract Background Sphincter sparing surgery is oftentimes associated with bowel dysfunction complaints, namely the low anterior resection syndrome (LARS). The LARS... -
Assessment of research waste part 1: an exemplar from examining study design,...
Abstract Background Research waste is estimated to be very common, but assessments of its prevalence and scope are rare. As an example, we assessed research waste in clinical... -
Fracture risk and healthcare resource utilization and costs among osteoporosi...
Abstract Background Osteoporosis, osteoporosis-related fractures, and diabetes are considerable health burdens in Japan. Diabetes in patients with osteoporosis has been reported... -
Derivation and validation of an easy-to-compute trauma score that improves pr...
Abstract Background Multiple trauma scores have been developed and validated, including the Revised Trauma Score (RTS) and the Mechanism, Glasgow Coma Scale, Age, and Arterial... -
Partial factorial trials: comparing methods for statistical analysis and econ...
Abstract Background Partial factorial trials compare two or more pairs of treatments on overlapping patient groups, randomising some (but not all) patients to more than one... -
Acute respiratory failure in immunocompromised patients: outcome and clinical...
Abstract Background The impact of neutropenia in critically ill immunocompromised patients admitted in a context of acute respiratory failure (ARF) remains uncertain. The... -
Plasma sTNFR1 and IL8 for prognostic enrichment in sepsis trials: a prospecti...
Abstract Background Enrichment strategies improve therapeutic targeting and trial efficiency, but enrichment factors for sepsis trials are lacking. We determined whether... -
Neoadjuvant chemotherapy-induced decrease of prognostic nutrition index predi...
Abstract Background The prognostic nutritional index (PNI), which is an easily calculated nutritional index, is significantly associated with patient outcomes in various solid... -
Elevated serum iron level is a predictor of prognosis in ICU patients with ac...
Abstract Background Accumulation of iron is associated with oxidative stress, inflammation, and regulated cell death processes that contribute to the development of acute kidney... -
Redefining chemotherapy-induced peripheral neuropathy through symptom cluster...
Abstract Background Chemotherapy-induced peripheral neuropathy (CIPN) is common among cancer patients treated with neurotoxic chemotherapy agents. Better knowledge on symptom... -
Consensus of potential modifiable prognostic factors for persistent pain afte...
Abstract Background Identify and establish consensus regarding potential prognostic factors for the development of chronic pain after a first episode of idiopathic,... -
Assessment of the risks of a myasthenic crisis after thymectomy in patients w...
Abstract Background Despite the burgeoning literature describing preoperative and postoperative risks of a myasthenic crisis after thymectomy (MCAT) in patients with myasthenia... -
The effect of continuity of care on the incidence of end-stage renal disease ...
Abstract Background Diabetic nephropathy requires periodic monitoring, dietary modification, and early intervention to prevent the disease severity within limited resource... -
Development and validation of a prognostic scoring model for Mycobacterium av...
Abstract Background Patients with Mycobacterium avium complex (MAC) lung disease (LD) have a heterogeneous prognosis. This study aimed to develop and validate a prognostic... -
Serum sST2 levels predict severe exacerbation of asthma
Abstract Background Neutrophilic inflammation is associated with poorly controlled asthma. Serum levels of sST2, a soluble IL-33 receptor, increase in neutrophilic lung... -
DNA methylation is associated with lung function in never smokers
Abstract Background Active smoking is the main risk factor for COPD. Here, epigenetic mechanisms may play a role, since cigarette smoking is associated with differential DNA... -
A randomized, 29-day, dose-ranging, efficacy and safety study of daprodustat,...
Abstract Background Daprodustat is a hypoxia-inducible factor-prolyl hydroxylase inhibitor currently being investigated as a treatment for anemia of chronic kidney disease (CKD)... -
Reference value for expiratory time constant calculated from the maximal expi...
Abstract Background The expiratory time constant (RCEXP), which is defined as the product of airway resistance and lung compliance, enable us to assess the mechanical properties... -
Serum albumin level as a potential marker for deciding chemotherapy or best s...
Abstract Background There have been few data on the chemotherapy in elderly advanced non-small cell lung cancer (NSCLC) patients with poor performance status (PS), and...
