-
Fracture risk and healthcare resource utilization and costs among osteoporosi...
Abstract Background Osteoporosis, osteoporosis-related fractures, and diabetes are considerable health burdens in Japan. Diabetes in patients with osteoporosis has been reported... -
Acute respiratory failure in immunocompromised patients: outcome and clinical...
Abstract Background The impact of neutropenia in critically ill immunocompromised patients admitted in a context of acute respiratory failure (ARF) remains uncertain. The... -
Plasma sTNFR1 and IL8 for prognostic enrichment in sepsis trials: a prospecti...
Abstract Background Enrichment strategies improve therapeutic targeting and trial efficiency, but enrichment factors for sepsis trials are lacking. We determined whether... -
Neoadjuvant chemotherapy-induced decrease of prognostic nutrition index predi...
Abstract Background The prognostic nutritional index (PNI), which is an easily calculated nutritional index, is significantly associated with patient outcomes in various solid... -
Redefining chemotherapy-induced peripheral neuropathy through symptom cluster...
Abstract Background Chemotherapy-induced peripheral neuropathy (CIPN) is common among cancer patients treated with neurotoxic chemotherapy agents. Better knowledge on symptom... -
The effect of continuity of care on the incidence of end-stage renal disease ...
Abstract Background Diabetic nephropathy requires periodic monitoring, dietary modification, and early intervention to prevent the disease severity within limited resource... -
Development and validation of a prognostic scoring model for Mycobacterium av...
Abstract Background Patients with Mycobacterium avium complex (MAC) lung disease (LD) have a heterogeneous prognosis. This study aimed to develop and validate a prognostic... -
Serum sST2 levels predict severe exacerbation of asthma
Abstract Background Neutrophilic inflammation is associated with poorly controlled asthma. Serum levels of sST2, a soluble IL-33 receptor, increase in neutrophilic lung... -
DNA methylation is associated with lung function in never smokers
Abstract Background Active smoking is the main risk factor for COPD. Here, epigenetic mechanisms may play a role, since cigarette smoking is associated with differential DNA... -
A randomized, 29-day, dose-ranging, efficacy and safety study of daprodustat,...
Abstract Background Daprodustat is a hypoxia-inducible factor-prolyl hydroxylase inhibitor currently being investigated as a treatment for anemia of chronic kidney disease (CKD)... -
Serum albumin level as a potential marker for deciding chemotherapy or best s...
Abstract Background There have been few data on the chemotherapy in elderly advanced non-small cell lung cancer (NSCLC) patients with poor performance status (PS), and... -
Design and rationale of the QUAZAR Lower-Risk MDS (AZA-MDS-003) trial: a rand...
Abstract Background CC-486 is an oral formulation of the epigenetic modifier azacitidine. In an expanded phase 1 trial, CC-486 demonstrated clinical and biological activity in... -
Polygenic risk for coronary heart disease acts through atherosclerosis in typ...
Abstract Background Type 2 diabetes increases the risk of coronary heart disease (CHD), yet the mechanisms involved remain poorly described. Polygenic risk scores (PRS) provide... -
Prospective stratification of patients at risk for emergency department revis...
Abstract Background Estimating patient risk of future emergency department (ED) revisits can guide the allocation of resources, e.g. local primary care and/or specialty, to... -
Increased expression of dedicator-cytokinesis-10, caspase-2 and Synaptotagmin...
Abstract Background We aim to identify differentially expressed genes (DEGs) and its pathways associated with clinical activity of relapsing–remitting Multiple Sclerosis (RRMS).... -
Comorbidities and COPD severity in a clinic-based cohort
Abstract Background Chronic obstructive pulmonary disease (COPD) is an important cause of morbidity and mortality around the world. The aim of our study was to determine the... -
Interaction according to urinary sodium excretion level on the association be...
Objective: We examined an interaction according to the estimated 24-h urinary sodium excretion on the association between ATP2B1 rs17249754 and incident hypertension. Methods:... -
Machine learning can predict survival of patients with heart failure from ser...
Abstract Background Cardiovascular diseases kill approximately 17 million people globally every year, and they mainly exhibit as myocardial infarctions and heart failures. Heart... -
Feasibility of anthropometric indices to identify dyslipidemia among adults i...
Abstract Background Dyslipidemia and other cardiovascular disease (CVD) risk factors have a strong association with obesity. Anthropometric indices have been widely used to... -
Serum GP73 predicts posthepatectomy outcomes in patients with hepatocellular ...
Abstract Background and aims Serum GP73 is a useful biomarker in assessing hepatic fibrosis degree. The aim of this study was to evaluate the predictive value of serum GP73...
