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Scl-Ab reverts pro-osteoclastogenic signalling and resorption in estrogen def...
Abstract Background Neutralising antibodies to sclerostin (Scl-Ab) have shown significant potential to induce bone formation and decrease bone resorption, increase strength and... -
Comparative analyses of the in vivo induction and transmission of α-synuclein...
Abstract α-synuclein (αS) is the major component of several types of brain pathological inclusions that define neurodegenerative diseases termed synucleinopathies. Central... -
Incidence and diagnosis of Acute kidney injury in hospitalized adult patients...
Abstract Background Acute kidney injury (AKI) places a heavy burden on the healthcare system in China and is usually misdiagnosed. However, there are limited studies that have... -
Cumulative fluid accumulation is associated with the development of acute kid...
Abstract Background Acute kidney injury (AKI) is common in patients in the intensive care unit (ICU) and may be present on admission or develop during ICU stay. Our objectives... -
Configurations for obtaining in-consultation assistance from supervisors in g...
Abstract Background General practice (GP) trainees may seek supervisor assistance to complete their patient consultations. This in-consultation assistance plays a key role in... -
TSS seq based core promoter architecture in blood feeding Tsetse fly (Glossin...
Abstract Background Transcription initiation regulation is mediated by sequence-specific interactions between DNA-binding proteins (transcription factors) and cis-elements,... -
Cardiovascular secondary prevention in high-risk patients: a randomized contr...
Abstract Background Enhanced cardiovascular secondary preventive follow-up is needed to improve adherence to recommended low-density lipoprotein cholesterol (LDL-C) and blood... -
Molecular mechanism of the priming by jasmonic acid of specific dehydration s...
Abstract Background Plant genes that provide a different response to a similar dehydration stress illustrate the concept of transcriptional ‘dehydration stress memory’.... -
Comparative effectiveness of immunosuppressive drugs and corticosteroids for ...
Abstract Background There is a lack of high-quality meta-analyses and network meta-analyses of immunosuppressive drugs for lupus nephritis. Our objective was to assess the... -
Prevalence of smoking and clinical characteristics in fibromuscular dysplasia...
Purpose: Smoking was identified as a potential factor contributing to fibromuscular dysplasia (FMD). To evaluate the prevalence of smoking and clinical characteristics in FMD... -
Variability in intensive care unit admission among pregnant and postpartum wo...
Abstract Background Pregnancy-related critical illness results in approximately 300,000 deaths globally each year. The objective was to describe the variation in ICU admission... -
The KDIGO acute kidney injury guidelines for cardiac surgery patients in crit...
Abstract Background The Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury (AKI) guidelines assign the same stage of AKI to patients whether they fulfil urine... -
The effect of polymyxin B hemoperfusion on modulation of human leukocyte anti...
Abstract Background Recent randomized trials have not found that polymyxin B hemoperfusion (PMX-HP) improves outcomes for patients with sepsis. However, it remains unclear... -
Perioperative poor grip strength recovery is associated with 30-day complicat...
Abstract Background Although perioperative care during heart surgery has improved considerably, the rate of postoperative complications has remained stable. It has not been... -
A worldwide multicentre evaluation of the influence of deterioration or impro...
Abstract Background Acute kidney injury (AKI) is a common complication of critical illness and is associated with worse outcomes. However, the influence of deterioration or... -
Financial incentives versus standard of care to improve patient compliance wi...
Abstract Background Live kidney donors (LKDs) account for nearly a third of kidney transplants in the United States. While donor nephrectomy poses minimal post-surgical risk,... -
Genetic variants in SERPINA4 and SERPINA5, but not BCL2 and SIK3 are associat...
Abstract Background Acute kidney injury (AKI) is a multifactorial syndrome, but knowledge about its pathophysiology and possible... -
Challenges of one-year longitudinal follow-up of a prospective, observational...
Abstract Background Trainee research collaboratives (TRCs) have pioneered high quality, prospective ‘snap-shot’ surgical cohort studies in the UK. Outcomes After Kidney injury... -
Transient systolic anterior motion with junctional rhythm after mitral valve ...
Abstract Systolic anterior motion (SAM) after mitral valve repair (MVR) can adversely affect hemodynamics due to exacerbation of left ventricular outflow tract obstruction and... -
Hemodynamic responses to tracheal intubation with Bonfils compared to C-MAC v...
Abstract Background Direct laryngoscopy (DL) produce tachycardia and hypertension that could be fatal in a patient with a brain injury. Bonfils fiberscope and C-MAC...
