-
Cherenkov luminescence imaging is a fast and relevant preclinical tool to ass...
Abstract Purpose Molecular imaging techniques visualise biomarkers for both drug development and personalised medicine. In this field, Cherenkov luminescence imaging (CLI) seems... -
The NuA4 acetyltransferase and histone H4 acetylation promote replication rec...
Abstract Background Histone acetylation plays an important role in DNA replication and repair because replicating chromatin is subject to dynamic changes in its structures.... -
Improving squalene production by enhancing the NADPH/NADP+ ratio, modifying t...
Abstract Background Squalene is currently used widely in the food, cosmetics, and medicine industries. It could also replace petroleum as a raw material for fuels. Microbial... -
Predictors of the use of analgesic drugs 1 year after joint replacement: a si...
Abstract Background Pain persists in a moderate number of patients following hip or knee replacement surgery. Persistent pain may subsequently lead to the prolonged consumption... -
Isolation and functional validation of the CmLOX08 promoter associated with s...
Abstract Background Lipoxygenases (LOXs) play significant roles in abiotic stress responses, and identification of LOX gene promoter function can make an important contribution... -
DNA replication dynamics of vole genome and its epigenetic regulation
Abstract Background The genome of some vole rodents exhibit large blocks of heterochromatin coupled to their sex chromosomes. The DNA composition and transcriptional activity of... -
Interplay between FACT subunit SPT16 and TRIM33 can remodel chromatin at macr...
Abstract Background Cell type-specific use of cis-acting regulatory elements is mediated by the combinatorial activity of transcription factors involved in lineage determination... -
Long-term prenatal exposure to paracetamol is associated with DNA methylation...
Abstract Background Epidemiological studies have shown that long-term exposure to paracetamol during pregnancy is associated with attention-deficit/hyperactivity disorder... -
High-throughput sequencing of small RNAs revealed the diversified cold-respon...
Abstract Background Cold stress is one of the most severe abiotic stresses affecting the banana production. Although some miRNAs have been identified, little is known about the... -
Characteristics of functional enrichment and gene expression level of human p...
Abstract Background Transcriptional target genes show functional enrichment of genes. However, how many and how significantly transcriptional target genes include functional... -
Inflammatory pre-conditioning restricts the seeded induction of α-synuclein p...
Abstract Background Cell-to-cell transmission of α-synuclein (αSyn) is hypothesized to play an important role in disease progression in synucleinopathies. This process involves... -
Intraflagellar transport proteins are involved in thrombocyte filopodia forma...
Intraflagellar transport (IFT) proteins are vital for the genesis and maintenance of cilia. Our identification of ift122 transcripts in zebrafish thrombocytes that lack primary... -
Can terminators be used as insulators into yeast synthetic gene circuits?
Abstract Background In bacteria, transcription units can be insulated by placing a terminator in front of a promoter. In this way promoter leakage due to the read-through from... -
Resveratrol Binding to Human Complement fragment 5a (<sup>h</sup>C5a) may Mod...
Resveratrol (RSV), the active pharmaceutical ingredient (API) found in several fruits, nuts and marketed nutraceuticals is one of the promiscuous phytoalexin known to promote... -
DNA replication stress: a source of APOBEC3B expression in breast cancer
Abstract APOBEC cytidine deaminases have been implicated as major contributors to the mutation burden in many cancers on the basis of their mutational signature. A new... -
Childhood traumatization is associated with differences in TRPA1 promoter met...
Abstract Background The construct of multisomatoform disorder (MSD) is a common point of reference for patients in different somatic and psychosomatic specialties and therefore... -
A CLCA regulatory protein present in the chemosensory cilia of olfactory sens...
Abstract Background CLCA is a family of metalloproteases that regulate Ca2+-activated Cl− fluxes in epithelial tissues. In HEK293 cells, CLCA1 promotes membrane expression of an... -
Upregulated 5-HT1A receptor-mediated currents in the prefrontal cortex layer ...
Abstract Serotonin (5-HT) is a well-known modulator of behavioral, physiological, and emotional functions of the forebrain region. We recently discovered alterations of... -
New Highly Active Antiretroviral drugs and generic drugs for the treatment of...
Abstract Background In the healthcare sector, it is crucial to identify sustainable strategies in order to allow the introduction and use of innovative technologies. Now, and... -
Correlation between global methylation level of peripheral blood leukocytes a...
Abstract Background Chronic inflammatory conditions are associated with higher tumor incidence through epigenetic and genetic alterations. Here, we focused on an association...
