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Cherenkov luminescence imaging is a fast and relevant preclinical tool to ass...
Abstract Purpose Molecular imaging techniques visualise biomarkers for both drug development and personalised medicine. In this field, Cherenkov luminescence imaging (CLI) seems... -
The NuA4 acetyltransferase and histone H4 acetylation promote replication rec...
Abstract Background Histone acetylation plays an important role in DNA replication and repair because replicating chromatin is subject to dynamic changes in its structures.... -
Structural alteration of DNA induced by viral protein R of HIV-1 triggers the...
Abstract Background Viral protein R (Vpr) is an accessory protein of HIV-1, which is potentially involved in the infection of macrophages and the induction of the... -
Narcissistic traits in young people: understanding the role of parenting and ...
Abstract Background Elevated narcissism in young people often sets up a cascade of interpersonal and mental health challenges, reinforcing the need to understand its... -
Combining the use of Nuss procedure and rib fixation for severe flail chest: ...
Abstract Background Severe flail chest is a life-threatening situation. The Nuss procedure is a new effective treatment for severe flail chest patients who cannot be weaned from... -
The respiratory pressure—abdominal volume curve in a porcine model
Abstract Background Increasing intra-abdominal volume (IAV) can lead to intra-abdominal hypertension (IAH) or abdominal compartment syndrome. Both are associated with raised... -
Influenza A virus enhances ciliary activity and mucociliary clearance via TLR...
Abstract Background Viral respiratory tract infections, such as influenza A virus (IAV), are common and life-threatening illnesses worldwide. The mechanisms by which viruses are... -
Link of dysfunctional attitudes with the negative self-model
Abstract Background Beck’s cognitive theory postulates that dysfunctional attitudes predisposing to depression are formed by early negative experiences. Meanwhile, Bowlby’s... -
Isolation and functional validation of the CmLOX08 promoter associated with s...
Abstract Background Lipoxygenases (LOXs) play significant roles in abiotic stress responses, and identification of LOX gene promoter function can make an important contribution... -
Onset, timing, and exposure therapy of stress disorders: mechanistic insight ...
Abstract Background The hypothalamic-pituitary-adrenal (HPA) axis is a neuroendocrine system that regulates numerous physiological processes. Disruptions in the activity of the... -
DNA replication dynamics of vole genome and its epigenetic regulation
Abstract Background The genome of some vole rodents exhibit large blocks of heterochromatin coupled to their sex chromosomes. The DNA composition and transcriptional activity of... -
Interplay between FACT subunit SPT16 and TRIM33 can remodel chromatin at macr...
Abstract Background Cell type-specific use of cis-acting regulatory elements is mediated by the combinatorial activity of transcription factors involved in lineage determination... -
Long-term prenatal exposure to paracetamol is associated with DNA methylation...
Abstract Background Epidemiological studies have shown that long-term exposure to paracetamol during pregnancy is associated with attention-deficit/hyperactivity disorder... -
Characteristics of functional enrichment and gene expression level of human p...
Abstract Background Transcriptional target genes show functional enrichment of genes. However, how many and how significantly transcriptional target genes include functional... -
Fostering teaching-learning through workplace based assessment in postgraduat...
Abstract Background The principle of workplace based assessment (WBA) is to assess trainees at work with feedback integrated into the program simultaneously. A student driven... -
Intraflagellar transport proteins are involved in thrombocyte filopodia forma...
Intraflagellar transport (IFT) proteins are vital for the genesis and maintenance of cilia. Our identification of ift122 transcripts in zebrafish thrombocytes that lack primary... -
Can terminators be used as insulators into yeast synthetic gene circuits?
Abstract Background In bacteria, transcription units can be insulated by placing a terminator in front of a promoter. In this way promoter leakage due to the read-through from... -
Childhood traumatization is associated with differences in TRPA1 promoter met...
Abstract Background The construct of multisomatoform disorder (MSD) is a common point of reference for patients in different somatic and psychosomatic specialties and therefore... -
Respiratory mechanics in infants with severe bronchiolitis on controlled mech...
Abstract Background Analysis of respiratory mechanics during mechanical ventilation (MV) is able to estimate resistive, elastic and inertial components of the working pressure... -
A CLCA regulatory protein present in the chemosensory cilia of olfactory sens...
Abstract Background CLCA is a family of metalloproteases that regulate Ca2+-activated Cl− fluxes in epithelial tissues. In HEK293 cells, CLCA1 promotes membrane expression of an...
